α4β1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism

Molecular Biology of the Cell

Volumn 13, Issue 9, 2002, Pages 3203-3217

  Pinco, Karen A ^a   He, Wei ^a   Yang, Joy T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; INTEGRIN ALPHA 4 BETA 1; PAXILLIN; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; LIGAND; PHOSPHOPROTEIN; PHOTOPROTEIN; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL ASSAY; CELL MIGRATION; CELL MOTILITY; CELL MUTANT; CHINESE; FOCAL ADHESION; HAMSTER; LAMELLIPODIUM; MICROSCOPY; MUTATION; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SCRATCHING; WOUND; ANIMAL; BIOTINYLATION; CELL DIVISION; CELL MOTION; CHO CELL; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENETIC TRANSFECTION; METABOLISM; PHYSIOLOGY; PLASMID; SERODIAGNOSIS; SIGNAL TRANSDUCTION; TIME; WOUND HEALING;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

ANIMALS; BIOTINYLATION; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CHO CELLS; CRICETINAE; CYTOSKELETAL PROTEINS; FLOW CYTOMETRY; FOCAL ADHESIONS; GREEN FLUORESCENT PROTEINS; INTEGRIN ALPHA4BETA1; INTEGRIN ALPHA5BETA1; LIGANDS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MUTATION; PAXILLIN; PHOSPHOPROTEINS; PLASMIDS; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; WOUND HEALING;

EID: 0036708599     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.02-05-0086     Document Type: Article

References (53)

1. Pak to the future
2. Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells
3. Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: Collaborative interactions among integrins
4. Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein
5. Monoclonal antibodies to distinctive epitopes on the α and β subunits of the fibronectin receptor
6. Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains
7. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
8. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength
9. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
10. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1
11. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
12. Rho GTPases and the actin cytoskeleton
13. Phosphorylation of the integrin α4 cytoplasmic domain regulates paxillin binding
14. Production and characterization of monoclonal antibodies against pigtailed macaque (Macaca nemestrina) cell adhesion molecules
15. Cell migration-movin'on
16. Integrins: Versatility, modulation, and signaling in cell adhesion
17. Specialized functional properties of the integrin α4 cytoplasmic domain
18. Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin
19. The alpha4 subunit of integrin is important for neural crest cell migration
20. Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
21. Cell migration: A physically integrated molecular process
22. Differential dynamics of α5 integrin, paxillin, and α-actinin during formation and disassembly of adhesions in migrating cells
23. Binding of paxillin to α4 integrins modifies integrin-dependent biological responses
24. Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1
25. The Arp2/3 complex: A multifunctional actin organizer
26. Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo
27. Tyrosine phosphorylation of paxillin α is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells
28. Cloning and expression of cDNAs for the α subunit of the murine lymphocyte-Peyer's patch adhesion molecule
29. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
30. Cell locomotion and focal adhesions are regulated by substrate flexibility
31. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
32. alpha4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development
33. Identification and isolation of a 140 kD cell surface glycoprotein with properties expected of a fibronectin receptor
34. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts
35. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
36. Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor
37. A novel RGD-independent fibronectin assembly pathway initiated by α4β1 integrin binding to the alternatively spliced V region
38. Dual functions of α4β1 integrin in epicardial development: Initial migration and long-term attachment
39. Expanding roles for a4 integrin and its ligands in development
40. Functional design in the actin cytoskeleton
41. Focal adhesion motility revealed in stationary fibroblasts
42. Regulation of lymphocyte pseudopodia formation by triggering the integrin α4/β1
43. The primary structure of the alpha 4 subunit of VLA-4: Homology to other integrins and a possible cell-cell adhesion function
44. Adhesion and migration of avian neural crest cells on fibronectin require the cooperating activities of multiple integrins of the β1 and β3 families
45. Paxillin and focal adhesion signaling
46. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
47. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin
48. Adhesion assembly, disassembly and turnover in migrating cells - Over and over and over again
49. The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)
50. Activation of the yeast Arp2/3 complex by Beelp, a WASP-family protein
51. The role of alpha 4 beta 1 integrin in cell motility and fibronectin matrix assembly
52. Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by αV integrins
53. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4 β1 integrin