Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice

Anesthesiology

Volumn 109, Issue 3, 2008, Pages 465-472

  Vaneker, Michiel ^c   Joosten, Leo A ^b   Heunks, Leo M A ^a   Snijdelaar, Dirk G ^a   Halbertsma, Feico J ^c,d   Van Egmond, Jan ^a   Netea, Mihai G ^c   Van Der Hoeven, Johannes G ^a   Scheffer, Gert Jan ^a  

^a Department of Anesthesiology ^*

^b Departments of Rheumatology and Internal Medicine

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MÁXIMA MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; CYTOKINE; INTERLEUKIN DERIVATIVE; LIGAND; MESSENGER RNA; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; INFLAMMATION; LEUKOCYTE; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TIDAL VOLUME; ANIMAL; BLOOD; C57BL MOUSE; CELL COUNT; CELL CULTURE; CHEMISTRY; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; METHODOLOGY; MOUSE MUTANT; REFERENCE VALUE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELLS, CULTURED; CHEMOKINES; CYTOKINES; INFLAMMATION; INTERLEUKINS; LEUKOCYTES; LIGANDS; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REFERENCE VALUES; RESPIRATION, ARTIFICIAL; RNA, MESSENGER; TIDAL VOLUME; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52649161185     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318182aef1     Document Type: Article

References (57)

1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342:1301-8
2. Gajic O, Dara SI, Mendez JL, Adesanya AO, Festic E, Caples SM, Rana R, St Sauver JL, Lymp JF, Afessa B, Hubmayr RD: Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 2004; 32:1817-24
3. Pinhu L, Whitehead T, Evans T, Griffiths M: Ventilator-associated lung injury. Lancet 2003; 361:332-40
4. Dirocco JD, Pavone LA, Carney DE, Lutz CJ, Gatto LA, Landas SK, Nieman GF: Dynamic alveolar mechanics in four models of lung injury. Intensive Care Med 2006; 32:140-8
5. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124:783-801
6. Chaby R, Garcia-Verdugo I, Espinassous Q, Augusto LA: Interactions between LPS and lung surfactant proteins. J Endotoxin Res 2005; 11:181-5
7. Miggin SM, O'neill LA: New insights into the regulation of TLR signaling. J Leukoc Biol 2006; 80:220-6
8. Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS: Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 2005; 73:1754-63
9. Beutler B: Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430:257-63
10. Akira S, Takeda K: Functions of toll-like receptors: Lessons from KO mice. C R Biol 2004; 327:581-9
11. Matzinger P: The danger model: A renewed sense of self. Science 2002; 296:301-5
12. Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L, McIntyre RC: Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 2004; 287:R592-9
13. Fan J, Li Y, Vodovotz Y, Billiar TR, Wilson MA: Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: Role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol 2006; 290:L738-46
14. Frink M, Hsieh YC, Thobe BM, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH: TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 2007; 44:2625-30
15. Shimamoto A, Pohlman TH, Shomura S, Tarukawa T, Takao M, Shimpo H: Toll-like receptor 4 mediates lung ischemia-reperfusion injury. Ann Thorac Surg 2006; 82:2017-23
16. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE: Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock 2007; 28:447-52
17. Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005; 11:1173-9
18. Ohashi K, Burkart V, Flohe S, Kolb H: Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000; 164:558-61
19. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF III: The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001; 276:10229-33
20. Johnson GB, Brunn GJ, Platt JL: Cutting edge: An endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4. J Immunol 2004; 172:20-4
21. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005; 115:2223-33
22. Taylor KR, Trowbridge JM, Rudisill JA, Termeer CC, Simon JC, Gallo RL: Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem 2004; 279:17079-84
23. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der PT, Sorg C, Roth J: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007; 13:1042-9
24. Vaneker M, Halbertsma FJ, van EJ, Netea MG, Dijkman HB, Snijdelaar DG, Joosten LA, van der Hoeven JG, Scheffer GJ: Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: An in vivo model using clinical relevant ventilation settings. ANESTHESIOLOGY 2007; 107:419-26
25. Popa C, Abdollahi-Roodsaz S, Joosten LA, Takahashi N, Sprong T, Matera G, Liberto MC, Foca A, van DM, Kullberg BJ, van den Berg WB, Van der Meer JW, Netea MG: Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4. Infect Immun 2007; 75:4831-7
26. Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, Radstake TR, Matera G, Popa C, Van der Meer JW, Netea MG, van den Berg WB: Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007; 56:2957-67
27. Netea MG, Demacker PN, Kullberg BJ, Boerman OC, Verschueren I, Stalenhoef AF, Van der Meer JW: Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest 1996; 97:1366-72
28. Caruso P, Meireles SI, Reis LF, Mauad T, Martins MA, Deheinzelin D: Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats. Intensive Care Med 2003; 29:1808-11
29. Myrianthefs P, Boutzouka E, Venetsanou K, Papalois A, Kouloukousa M, Kittas C, Baltopoulos G: Effect of different ventilatory strategies on local and systemic cytokine production in intact swine lungs in vivo. Vascul Pharmacol 2006; 44:283-9
30. Dhanireddy S, Altemeier WA, Matute-Bello G, O'Mahony DS, Glenny RW, Martin TR, Liles WC: Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Lab Invest 2006; 86:790-9
31. Gurkan OU, O'Donnell C, Brower R, Ruckdeschel E, Becker PM: Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol 2003; 285:L710-8
32. Takenaka K, Nishimura Y, Nishiuma T, Sakashita A, Yamashita T, Kobayashi K, Satouchi M, Ishida T, Kawashima S, Yokoyama M: Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 2006; 290:L1078-86
33. Kim JY, Park JS, Strassheim D, Douglas I, Diaz d V, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E: HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol 2005; 288:L958-65
34. Glasgow SC, Ramachandran S, Blackwell TS, Mohanakumar T, Chapman WC: Interleukin-1β is the primary initiator of pulmonary inflammation following liver injury in mice. Am J Physiol Lung Cell Mol Physiol 2007; 293:L491-6
35. Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL: Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007; 13:851-6
36. Stefanovic L, Brenner DA, Stefanovic B: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med (May-wood) 2005; 230:573-86
37. Bregeon F, Roch A, Delpierre S, Ghigo E, Autillo-Touati A, Kajikawa O, Martin TR, Pugin J, Portugal H, Auffray JP, Jammes Y: Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir Physiol Neurobiol 2002; 132:191-203
38. Headley AS, Tolley E, Meduri GU: Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997; 111:1306-21
39. Meduri GU, Headley S, Kohler G, Stentz F, Tolley E, Umberger R, Leeper K: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS: Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome overtime. Chest 1995; 107:1062-73
40. Slutsky AS, Tremblay LN: Multiple system organ failure: Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157:1721-5
41. Murphy TJ, Paterson HM, Kriynovich S, Zang Y, Kurt-Jones EA, Mannick JA, Lederer JA: Linking the "two-hit" response following injury to enhanced TLR4 reactivity. J Leukoc Biol 2005; 77:16-23
42. Kawano T, Mori S, Cybulsky M, Burger R, Ballin A, Cutz E, Bryan AC: Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 1987; 62:27-33
43. Neff TA, Guo RF, Neff SB, Sarma JV, Speyer CL, Gao H, Bernacki KD, Huber-Lang M, McGuire S, Hoesel LM, Riedemann NC, Beck-Schimmer B, Ze-toune FS, Ward PA: Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol 2005; 166:685-94
44. Poltorak A, He X, Smirnova I, Liu MY, Van HC, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8
45. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005; 115:2223-33
46. Wilson MR, Choudhury S, Takata M: Pulmonary inflammation induced by high stretch ventilation is mediated by tumor necrosis factor signalling in mice. Am J Physiol Lung Cell Mol Physiol 2005; 288:599-607
47. Huang HC, Shieh CC, Yu WL, Cheng KC, Chen CC, Chang ST, Chuang YC: Comparing the protective effects of ciprofloxacin, moxifloxacin and levofloxacin in mice with lipopolysaccharide-induced acute lung injuries. Respirology 2008; 13:47-52
48. Hillman NH, Moss TJ, Kallapur SG, Bachurski C, Pillow JJ, Polglase GR, Nitsos I, Kramer BW, Jobe AH: Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep. Am J Respir Crit Care Med 2007; 176:575-81
49. Trinchieri G, Sher A: Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007; 7:179-90
50. Tsan MF, Gao B: Endogenous ligands of Toll-like receptors. J Leukoc Biol 2004; 76:514-9
51. Homburger JA, Meiler SE: Anesthesia drugs, immunity, and long-term outcome. Curr Opin Anaesthesiol 2006; 19:423-8
52. Chang Y, Chen TL, Sheu JR, Chen RM: Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol 2005; 204:27-35
53. Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A: Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999; 89:665-9
54. Yu Y, ZhouZ, XuJ, LiuZ, Wang Y: Ketamine reduces NFkB activation and TNFa production in rat mononuclear cells induced by lipopolysaccharide in vitro. Ann Clin Lab Sci 2002; 32:292-8
55. Yang J, Li W, Duan M, Zhou Z, Lin N, Wang Z, Sun J, XuJ: Large dose ketamine inhibits lipopolysaccharide-induced acute lung injury in rats. Inflamm Res 2005; 54:133-7
56. Yu M, Shao D, Liu J, Zhu J, Zhang Z, XuJ: Effects of ketamine on levels of cytokines, NF-KB and TLRs in rat intestine during CLP-induced sepsis. Int Immunopharmacol 2007; 7:1076-82
57. Beilin B, Rusabrov Y, Shapira Y, Roytblat L, Greemberg L, Yardeni IZ, Bessler H: Low-dose ketamine affects immune responses in humans during the early postoperative period. Br J Anaesth 2007; 99:522-7