Ketamine reduces NFκB activation and TNFα production in rat mononuclear cells induced by lipopolysaccharide in vitro

Annals of Clinical and Laboratory Science

Volumn 32, Issue 3, 2002, Pages 292-298

  Yu, Yingqun ^a   Zhou, Zhiqiang ^a   Xu, Jianguo ^a   Liu, Zhihai ^a   Wang, Yu ^a  

^a JINLING HOSPITAL   (China)

Author keywords

Endotoxemia; Ketamine; Mononuclear cells; Nuclear factor B; Tumor necrosis factor

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETAMINE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; AMINO ACID RECEPTOR BLOCKING AGENT; ANESTHETIC AGENT; I KAPPA B;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; INCUBATION TIME; INHIBITION KINETICS; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MONOCYTE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANESTHETICS, DISSOCIATIVE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; EXCITATORY AMINO ACID ANTAGONISTS; I-KAPPA B PROTEINS; KETAMINE; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036022327     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ketamine anesthesia in a patient with septic shock
2. Ketamine suppresses proinflammatory cytokine production in human whole blood. In Vitro
3. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood
4. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
5. NF-κB activation
6. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
7. Activation In Vitro of NF-κB by phosphorylation of its inhibitor IκB
8. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
9. Sequential cardiorespiratory patterns of anesthetic induction with ketamine in critically ill patients
10. Evaluation of a xylazine-ketamine hydrochloride combination in the cat
11. Effect of ketamine, althesin, and thiopentone on the Valsalvaconstrictor and heart rat reflexes of the rabbit
12. Ketamine suppresses tumor necrosis factor-α activity and mortality in carrgeenan-sensitized endotoxin shock model
13. Ketamine inhibits endotoxin-induced shock in rat
14. Ketamine inhibits nitric oxide production in mouse-activated macrophage-like cells
15. Ketamine suppresses endotoxin-induced NF-κB expression
16. Methamphetamine induces AP-1 and NF-kappaB binding and transactivation in human brain endothelial cells
17. Cocaine activates redox-regulated transcription factors and induces TNF-alpha expression in human brain endothelial cells
18. Increased nuclear factor κB activation in critically ill patients who die
19. Pharmacokinetics of ketamine in man
20. Ketamine infusions: Pharmacokinetics and clinical effect
21. Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass
22. Preoperative low dose ketamine reduces serum interleukin-6 response after abdominal hysterectomy
23. Ketamine inhibits nitric oxide synthase in lipopolysaccharide-treated rat alveolar macrophages
24. The in vitro effects of ketamine at large concentrations can be attributed to a nonspecific cytostatic effect