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Volumn 22, Issue 3, 2008, Pages 198-203

Whatever happened to Pittsburgh Compound-A?

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; APOLIPOPROTEIN E; CONGO RED; FLUORINE 18; PITTSBURGH COMPOUND A; PITTSBURGH COMPOUND A C 11; PITTSBURGH COMPOUND B; RADIOPHARMACEUTICAL AGENT; THIOFLAVINE; UNCLASSIFIED DRUG;

EID: 52649120423     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e318188c0c8     Document Type: Review
Times cited : (7)

References (42)
  • 1
    • 2342446265 scopus 로고    scopus 로고
    • Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
    • Mathis CA, Wang Y, Klunk WE. Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des. 2004;10:1469-1492.
    • (2004) Curr Pharm Des , vol.10 , pp. 1469-1492
    • Mathis, C.A.1    Wang, Y.2    Klunk, W.E.3
  • 2
    • 0029083059 scopus 로고
    • Chrysamine-G binding to Alzheimer and control brain: Autopsy study of a new amyloid probe
    • Klunk WE, Debnath ML, Pettegrew JW. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging. 1995;16:541-548.
    • (1995) Neurobiol Aging , vol.16 , pp. 541-548
    • Klunk, W.E.1    Debnath, M.L.2    Pettegrew, J.W.3
  • 3
    • 0032500717 scopus 로고    scopus 로고
    • Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells
    • Klunk WE, Debnath ML, Koros AM, et al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci. 1998;63:1807-1814.
    • (1998) Life Sci , vol.63 , pp. 1807-1814
    • Klunk, W.E.1    Debnath, M.L.2    Koros, A.M.3
  • 4
    • 0037110932 scopus 로고    scopus 로고
    • Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
    • Ishii K, Klunk WE, Arawaka S, et al. Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice. Neurosci Lett. 2002;333:5-8.
    • (2002) Neurosci Lett , vol.333 , pp. 5-8
    • Ishii, K.1    Klunk, W.E.2    Arawaka, S.3
  • 5
    • 0033857342 scopus 로고    scopus 로고
    • X-34, a fluorescent derivative of Congo red: A novel histochemical stain for Alzheimer's disease pathology
    • Styren SD, Hamilton RL, Styren GC, et al. X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem. 2000;48: 1223-1232.
    • (2000) J Histochem Cytochem , vol.48 , pp. 1223-1232
    • Styren, S.D.1    Hamilton, R.L.2    Styren, G.C.3
  • 6
    • 33749607070 scopus 로고    scopus 로고
    • X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease
    • Ikonomovic MD, Abrahamson EE, Isanski BA. et al. X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease. Methods Enzymol. 2006:412:123 144.
    • (2006) Methods Enzymol , vol.412 , pp. 123-144
    • Ikonomovic, M.D.1    Abrahamson, E.E.2    Isanski, B.A.3
  • 7
    • 0036707494 scopus 로고    scopus 로고
    • Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
    • Klunk WE. Bacskai BJ. Mathis CA, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. .J Neuro-pathol Exp Neurol. 2002;61:797-805.
    • (2002) J Neuro-pathol Exp Neurol , vol.61 , pp. 797-805
    • Klunk, W.E.1    Bacskai, B.J.2    Mathis, C.A.3
  • 9
    • 85047691873 scopus 로고    scopus 로고
    • Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
    • Brendza RP, Bacskai BJ, Cirrito JR, et al. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. .JClin Invest. 2005: 115:428-433.
    • (2005) JClin Invest , vol.115 , pp. 428-433
    • Brendza, R.P.1    Bacskai, B.J.2    Cirrito, J.R.3
  • 10
    • 38949123792 scopus 로고    scopus 로고
    • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
    • Meyer-Luehmann M, Spires-Jones TL, Prada C, et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008;451:720-724.
    • (2008) Nature , vol.451 , pp. 720-724
    • Meyer-Luehmann, M.1    Spires-Jones, T.L.2    Prada, C.3
  • 11
    • 0034691124 scopus 로고    scopus 로고
    • In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
    • Skovronsky DM, Zhang B, Kung MP, et al. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci V S A. 2000;97:7609-7614.
    • (2000) Proc Natl Acad Sci V S A , vol.97 , pp. 7609-7614
    • Skovronsky, D.M.1    Zhang, B.2    Kung, M.P.3
  • 12
    • 37349075778 scopus 로고    scopus 로고
    • Congo red and thioflavin-T analogs detect Abeta oligomers
    • Maezawa I. Hong HS, Liu R, et al. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008;104:457 468.
    • (2008) J Neurochem , vol.104 , pp. 457-468
    • Maezawa, I.1    Hong, H.S.2    Liu, R.3
  • 13
    • 3242674405 scopus 로고    scopus 로고
    • Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques
    • Sato K, Higuchi M, Iwata N, et al. Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem. 2004;39:573-578.
    • (2004) Eur J Med Chem , vol.39 , pp. 573-578
    • Sato, K.1    Higuchi, M.2    Iwata, N.3
  • 14
    • 20044392910 scopus 로고    scopus 로고
    • I9F and 1H MRI detection of amyloid beta plaques in vivo
    • Higuchi M. Iwata N, Matsuba Y, et al. I9F and 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci. 2005;8:527-533.
    • (2005) Nat Neurosci , vol.8 , pp. 527-533
    • Higuchi, M.1    Iwata, N.2    Matsuba, Y.3
  • 15
    • 0035902875 scopus 로고    scopus 로고
    • Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    • Klunk WE, Wang Y, Huang GF, et al. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 2001;69:1471-1484.
    • (2001) Life Sci , vol.69 , pp. 1471-1484
    • Klunk, W.E.1    Wang, Y.2    Huang, G.F.3
  • 16
    • 0037059914 scopus 로고    scopus 로고
    • A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
    • Mathis CA, Bacskai BJ, Kajdasz ST, et al. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Biorrg Med Chem Lett. 2002;12:295-298.
    • (2002) Biorrg Med Chem Lett , vol.12 , pp. 295-298
    • Mathis, C.A.1    Bacskai, B.J.2    Kajdasz, S.T.3
  • 17
    • 0141706482 scopus 로고    scopus 로고
    • Positron emission tomography microdosing: A new concept with application in tracer and early clinical drug development
    • Bergström M, Grahnén A, Långström B. Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development. Eur J Clin Pharmacol. 2003;59: 357-366.
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 357-366
    • Bergström, M.1    Grahnén, A.2    Långström, B.3
  • 18
    • 47949100719 scopus 로고    scopus 로고
    • The Exploratory IND
    • Mills G. The Exploratory IND. J Nucl Med. 2008;49:45N-47N.
    • (2008) J Nucl Med , vol.49
    • Mills, G.1
  • 19
    • 0038792263 scopus 로고    scopus 로고
    • Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    • Mathis CA, Wang Y, Holt DP, et al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003;46:2740-2754.
    • (2003) J Med Chem , vol.46 , pp. 2740-2754
    • Mathis, C.A.1    Wang, Y.2    Holt, D.P.3
  • 20
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306-319.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 21
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • Arnold SE, Hyman BT, Flory J, et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereh Cortex. 1991; 1:103 116.
    • (1991) Cereh Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3
  • 22
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997;18:351-357.
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 23
    • 0033624303 scopus 로고    scopus 로고
    • Sequence of Abeta-protein deposition in the human medial temporal lobe
    • Thal DR, Rub U. Schultz C, et al. Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropalhol Exp Neurol. 2000;59:733-748.
    • (2000) J Neuropalhol Exp Neurol , vol.59 , pp. 733-748
    • Thal, D.R.1    Rub, U.2    Schultz, C.3
  • 24
    • 0037008484 scopus 로고    scopus 로고
    • Helmuth L. Neuroscience. Long-awaited technique spots Alzheimer's toxin. Science. 2002;297:752-753.
    • Helmuth L. Neuroscience. Long-awaited technique spots Alzheimer's toxin. Science. 2002;297:752-753.
  • 25
    • 33947198109 scopus 로고    scopus 로고
    • Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report
    • Bacskai BJ, Frosch MP, Freeman SH, et al. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007;64:431-434.
    • (2007) Arch Neurol , vol.64 , pp. 431-434
    • Bacskai, B.J.1    Frosch, M.P.2    Freeman, S.H.3
  • 26
    • 43849083580 scopus 로고    scopus 로고
    • Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    • Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 2008;131:1630-1645.
    • (2008) Brain , vol.131 , pp. 1630-1645
    • Ikonomovic, M.D.1    Klunk, W.E.2    Abrahamson, E.E.3
  • 27
    • 33747048954 scopus 로고    scopus 로고
    • 11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006;67:446-452.
    • 11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006;67:446-452.
  • 28
    • 35648932901 scopus 로고    scopus 로고
    • β-Amyloid imaging and memory in non-demented individuals: Evidence for preclinical Alzheimer's disease
    • Pike KE, Savage G. Villemagne VL. et al. β-Amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 2007;130:2837-2844.
    • (2007) Brain , vol.130 , pp. 2837-2844
    • Pike, K.E.1    Savage, G.2    Villemagne, V.L.3
  • 29
    • 52649090494 scopus 로고    scopus 로고
    • Amyloid deposition is frequent and often is not associated with significant cognitive impairment in the elderly
    • In press
    • Aizenstein HJ. Nebes RD, Saxton JA, et al. Amyloid deposition is frequent and often is not associated with significant cognitive impairment in the elderly. Arch Neurol. 2008. In press.
    • (2008) Arch Neurol
    • Aizenstein, H.J.1    Nebes, R.D.2    Saxton, J.A.3
  • 30
    • 49349092320 scopus 로고    scopus 로고
    • PET imaging of amyloid deposition in patients with mild cognitive impairment
    • doi:10.1016/j.neurobiolaging.2007.03.029
    • Forsberg A, Engler H, Almkvist O, et al. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging. 2007;doi:10.1016/j.neurobiolaging.2007.03.029.
    • (2007) Neurobiol Aging
    • Forsberg, A.1    Engler, H.2    Almkvist, O.3
  • 31
    • 34248231779 scopus 로고    scopus 로고
    • PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment
    • Kemppainen NM, Aalto S, Wilson IA, et al. PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment. Neurology. 2007;68:1603-1606.
    • (2007) Neurology , vol.68 , pp. 1603-1606
    • Kemppainen, N.M.1    Aalto, S.2    Wilson, I.A.3
  • 32
    • 34248579291 scopus 로고    scopus 로고
    • Imaging beta-amyloid burden in aging and dementia
    • Rowe CC, Ng S, Ackermann U, et al. Imaging beta-amyloid burden in aging and dementia. Neurology. 2007;68:1718-1725.
    • (2007) Neurology , vol.68 , pp. 1718-1725
    • Rowe, C.C.1    Ng, S.2    Ackermann, U.3
  • 33
    • 39749108812 scopus 로고    scopus 로고
    • 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
    • Jack CR Jr, Lowe VJ, Senjem ML, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain. 2008; 131: 665-680.
    • (2008) Brain , vol.131 , pp. 665-680
    • Jack Jr, C.R.1    Lowe, V.J.2    Senjem, M.L.3
  • 34
    • 33748368729 scopus 로고    scopus 로고
    • Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment
    • Theuns J, Marjaux E, Vandenbulcke M, et al. Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment. Hum Mutat. 2006;27:888-896.
    • (2006) Hum Mutat , vol.27 , pp. 888-896
    • Theuns, J.1    Marjaux, E.2    Vandenbulcke, M.3
  • 35
    • 34249984684 scopus 로고    scopus 로고
    • Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    • Klunk WE, Price JC, Mathis CA, et al. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci. 2007;27:6174-6184.
    • (2007) J Neurosci , vol.27 , pp. 6174-6184
    • Klunk, W.E.1    Price, J.C.2    Mathis, C.A.3
  • 36
    • 42249109406 scopus 로고    scopus 로고
    • 11C-PIB-PET amyloid imaging in patients with APP locus duplication
    • 11C-PIB-PET amyloid imaging in patients with APP locus duplication. Arch Neurol. 2008; 65:540-544.
    • (2008) Arch Neurol , vol.65 , pp. 540-544
    • Remes, A.M.1    Laru, L.2    Tuominen, H.3
  • 38
    • 34247196532 scopus 로고    scopus 로고
    • 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
    • 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology. 2007;68:1205-1212.
    • (2007) Neurology , vol.68 , pp. 1205-1212
    • Rabinovici, G.D.1    Furst, A.J.2    O'Neil, J.P.3
  • 39
    • 36149001032 scopus 로고    scopus 로고
    • Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    • Drzezga A, Grimmer T, Henriksen G, et al. Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease. Neuroimage. 2008;39:619-633.
    • (2008) Neuroimage , vol.39 , pp. 619-633
    • Drzezga, A.1    Grimmer, T.2    Henriksen, G.3
  • 41
    • 34948819200 scopus 로고    scopus 로고
    • Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    • Johnson KA, Gregas M, Becker JA, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol. 2007;62:229-234.
    • (2007) Ann Neurol , vol.62 , pp. 229-234
    • Johnson, K.A.1    Gregas, M.2    Becker, J.A.3
  • 42
    • 37349126921 scopus 로고    scopus 로고
    • Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3′-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques
    • Neumaier B, Deisenhofer S, Furst D, et al. Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3′-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. Nuklear-medizin. 2007;46:271-280.
    • (2007) Nuklear-medizin , vol.46 , pp. 271-280
    • Neumaier, B.1    Deisenhofer, S.2    Furst, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.