Imaging hemodynamics

Cancer and Metastasis Reviews

Volumn 27, Issue 4, 2008, Pages 589-613

  Jennings, Dominique ^a   Raghunand, Natarajan ^b   Gillies, Robert J ^b,c  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Hemodynamics; Microcirculation; MRI; PET

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; 2 MORPHOLINO 8 PHENYLCHROMONE; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AE 941; AFLIBERCEPT; ALBUMIN TC 99M; AXITINIB; BEVACIZUMAB; CEDIRANIB; COMBRETASTATIN A4 PHOSPHATE; ENDOSTATIN; FLUOROURACIL; FUMAGILLOL CHLOROACETYLCARBAMATE; GADOLINIUM PENTETATE; HUMV 833; IMC 1121B; INDOCYANINE GREEN; IOFETAMINE I 123; MATRIGEL; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MONOCLONAL ANTIBODY LM 609; N ACETYLCOLCHINOL PHOSPHATE; NICOTINAMIDE; PENTETATE TECHNETIUM TC 99M; PX 866; SEMAXANIB; SHU 508; SONOVUE; SORAFENIB; SUNITINIB; THALLIUM CHLORIDE TL 201; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VATALANIB; WORTMANNIN;

ADVENTITIA; ANGIOGENESIS; BLOOD VESSEL PERMEABILITY; BRAIN TUMOR; BREAST TUMOR; CAPILLARY FLOW; CHORIOALLANTOIS; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; DOPPLER FLOWMETRY; HEAD AND NECK TUMOR; HEMODYNAMICS; HUMAN; INTIMA; KIDNEY TUMOR; LIVER METASTASIS; LIVER TUMOR; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MOLECULAR DYNAMICS; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PASSIVE TRANSPORT; PERFUSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE TUMOR; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE FLAP; TUNICA MEDIA;

ANIMALS; CAPILLARY PERMEABILITY; DIAGNOSTIC IMAGING; HEMODYNAMICS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 52549097282     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-008-9157-4     Document Type: Review

References (165)

1. Sherwood, L. (2001). Human physiology (4th ed.). Pacific Grove: Brooks/Cole.
2. Patton, H. D., Fuchs, A. F., Hille, B., Scher, A. M., & Steiner, R. (1989). Textbook of physiology: circulation, respiration, body fluids, metabolism and endocrinology (21st ed.). Philadelphia: Saunders.
3. P. Oh Y. Li J. Yu E. Durr K. M. Krasinska L. A. Carver 2004 Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy Nature 429 629 635
4. E. Durr J. Yu K. M. Krasinska L. A. Carver J. R. Yates J. E. Testa 2004 Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture Nature Biotechnology 22 985 992
5. S. S. Kety 1951 The theory and applications of the exchange of inert gas at the lungs and tissues Pharmacological Reviews 3 1 41
6. Murray, P. D. F. (1932). The development in vitro of the early chick embryo (pp. 497-521). Cambridge: Strangeways Research Laboratory.
7. L. Pardanaud D. Luton M. Prigent L. M. Bourcheix M. Catala F. Dieterlen-Lievre 1996 Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis Development 122 1363 1371
8. J. Palis K. E. McGrath P. D. Kingsley 1995 Initiation of hematopoiesis and vasculogenesis in murine yolk sac explants Blood 86 156 163
9. K. R. Mills D. Kruep M. S. Saha 1999 Elucidating the origins of the vascular system: a fate map of the vascular endothelial and red blood cell lineages in Xenopus laevis Developmental Biology 209 352 368
10. W. Risau I. Flamme 1995 Vasculogenesis Annual Review of Cell & Developmental Biology 11 73 91
11. J. E. Ferguson III R. W. Kelley C. Patterson 2005 Mechanisms of endothelial differentiation in embryonic vasculogenesis Arteriosclerosis, Thrombosis and Vascular Biology 25 2246 2254
12. M. G. Tonnesen X. Feng R. A. Clark 2000 Angiogenesis in wound healing Journal of Investigative Dermatology, Symposium Proceedings 5 40 46
13. L. P. Reynolds S. D. Killilea D. A. Redmer 1992 Angiogenesis in the female reproductive system FASEB Journal 6 886 892
14. Li, W. W. (2003). Angiogenesis in wound healing. Contemporary Surgery, Supplement, 1-36.
15. D. Hanahan R. A. Weinberg 2000 The hallmarks of cancer Cell 100 57 70
16. P. Schlatter M. F. Konig L. M. Karlsson P. H. Burri 1997 Quantitative study of intussusceptive capillary growth in the chorioallantoic membrane (CAM) of the chicken embryo Microvascular Research 54 65 73
17. W. Risau 1997 Mechanisms of angiogenesis Nature 386 671 674
18. V. Djonov M. Schmid S. A. Tschanz P. H. Burri 2000 Intussusceptive angiogenesis: its role in embryonic vascular network formation Circulation Research 86 286 292
19. V. Djonov O. Baum P. H. Burri 2003 Vascular remodeling by intussusceptive angiogenesis Cell and Tissue Research 314 107 117
20. S. Liekens E. De Clercq J. Neyts 2001 Angiogenesis: regulators and clinical applications Biochemical Pharmacology 61 253 270
21. R. Kalluri 2003 Basement membranes: structure, assembly and role in tumour angiogenesis Nature Reviews, Cancer 3 422 433
22. E. M. Conway D. Collen P. Carmeliet 2001 Molecular mechanisms of blood vessel growth Cardiovascular Research 49 507 521
23. P. Carmeliet 2000 Mechanisms of angiogenesis and arteriogenesis Nature Medicine 6 389 395
24. G. Thurston J. S. Rudge E. Ioffe H. Zhou L. Ross S. D. Croll 2000 Angiopoietin-1 protects the adult vasculature against plasma leakage Nature Medicine 6 460 463
25. H. R. Lijnen 2002 Extracellular proteolysis in the development and progression of atherosclerosis Biochemical Society Transactions 30 163 167
26. J. Bischoff 1997 Cell adhesion and angiogenesis Journal of Clinical Investigation 100 S37 S39
27. M. Papetti I. M. Herman 2002 Mechanisms of normal and tumor-derived angiogenesis American Journal of Physiology-Cell Physiology 282 C947 C970
28. J. C. Sandison 1924 A new method for the microscopic study of living growing tissues by introduction of a transparent chamber in the rabbit's ear Anatomical Record 28 281 287
29. M. Greenblatt P. Shubi 1968 Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique Journal of the National Cancer Institute 41 111 124
30. G. H. Algire H. W. Chalkley 1945 Vascular reactions of normal and malignant tissues in vivo Journal of the National Cancer Institute 3 73 85
31. G. H. Algire 1943 An adaptation of the transparent chamber technique to the mouse Journal of the National Cancer Institute 4 1 11
32. F. Yuan H. A. Salehi Y. Boucher U. S. Vasthare R. F. Tuma R. K. Jain 1994 Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows Cancer Research 54 4564 4568
33. M. Dellian B. P. Witwer H. A. Salehi F. Yuan R. K. Jain 1996 Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment American Journal of Pathology 149 59 71
34. R. Auerbach N. Akhtar R. L. Lewis B. L. Shinners 2000 Angiogenesis assays: problems and pitfalls Cancer and Metastasis Reviews 19 167 172
35. L. S. Heuser F. N. Miller 1986 Differential macromolecular leakage from the vasculature of tumors Cancer 57 461 464
36. I. Zeidman 1961 The fate of circulating tumors cells. I. Passage of cells through capillaries Cancer Research 21 38 39
37. R. K. Jain K. Schlenger M. Hockel F. Yuan 1997 Quantitative angiogenesis assays: progress and problems Nature Medicine 3 1203 1208
38. M. Nguyen Y. Shing J. Folkman 1994 Quantitation of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane Microvascular Research 47 31 40
39. R. Auerbach R. Arensman L. Kubai J. Folkman 1975 Tumor-induced angiogenesis: lack of inhibition by irradiation International Journal of Cancer 15 241 245
40. M. A. Gimbrone Jr. S. B. Leapman R. S. Cotran J. Folkman 1972 Tumor dormancy in vivo by prevention of neovascularization Journal of Experimental Medicine 136 261 276
41. R. Langer H. Brem K. Falterman M. Klein J. Folkman 1976 Isolations of a cartilage factor that inhibits tumor neovascularization Science 193 70 72
42. N. Akhtar E. B. Dickerson R. Auerbach 2002 The sponge/Matrigel angiogenesis assay Angiogenesis 5 75 80
43. A. Passaniti R. M. Taylor R. Pili Y. Guo P. V. Long J. A. Haney 1992 A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor Laboratory Investigation 67 519 528
44. N. Weidner J. P. Semple W. R. Welch J. Folkman 1991 Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma New England Journal of Medicine 324 1 8
45. A. Srivastava P. Laidler L. E. Hughes J. Woodcock E. J. Shedden 1986 Neovascularization in human cutaneous melanoma: a quantitative morphological and Doppler ultrasound study European Journal of Cancer & Clinical Oncology 22 1205 1209
46. E. Louvar P. J. Littrup A. Goldstein L. Yu W. Sakr D. Grignon 1998 Correlation of color Doppler flow in the prostate with tissue microvascularity Cancer 83 135 140
47. D. O. Cosgrove J. C. Bamber J. B. Davey J. A. McKinna H. D. Sinnett 1990 Color Doppler signals from breast tumors. Work in progress Radiology 176 175 180
48. D. D. Adler P. L. Carson J. M. Rubin D. Quinn-Reid 1990 Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings Ultrasound in Medicine and Biology 16 553 559
49. A. E. Koch 1998 Review: angiogenesis: implications for rheumatoid arthritis Arthritis & Rheumatism 41 951 962
50. J. Sebag J. W. McMeel 1986 Diabetic retinopathy. Pathogenesis and the role of retina-derived growth factor in angiogenesis Survey of Ophthalmology 30 377 384
51. D. Creamer D. Sullivan R. Bicknell J. Barker 2002 Angiogenesis in psoriasis Angiogenesis 5 231 236
52. G. Majno 1998 Chronic inflammation: links with angiogenesis and wound healing American Journal of Pathology 153 1035 1039
53. E. Ryschich J. Schmidt G. J. Hammerling E. Klar R. Ganss 2002 Transformation of the microvascular system during multistage tumorigenesis International Journal of Cancer 97 719 725
54. J. Holash S. J. Wiegand G. D. Yancopoulos 1999 New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF Oncogene 18 5356 5362
55. J. Folkman K. Watson D. Ingber D. Hanahan 1989 Induction of angiogenesis during the transition from hyperplasia to neoplasia Nature 339 58 61
56. P. Carmeliet R. K. Jain 2000 Angiogenesis in cancer and other diseases Nature 407 249 257
57. N. Weidner 1999 Tumour vascularity and proliferation: clear evidence of a close relationship Journal of Pathology 189 297 299
58. S. B. Fox 1997 Tumour angiogenesis and prognosis Histopathology 30 294 301
59. R. A. Gatenby R. J. Gillies 2004 Why do cancers have high aerobic glycolysis? Nature Reviews, Cancer 4 891 899
60. A. Krogh 1919 The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue Journal of Physiology 52 409 415
61. Cho, Z. H., Jones, J. P., & Singh, M. (1993). Foundations of medical imaging (1st ed.). New York: Wiley.
62. A. Yamaguchi H. Taniguchi S. Kunishima T. Koh H. Yamagishi 2000 Correlation between angiographically assessed vascularity and blood flow in hepatic metastases in patients with colorectal carcinoma Cancer 89 1236 1244
63. C. B. Wilson A. A. Lammertsma C. G. McKenzie K. Sikora T. Jones 1992 Measurements of blood flow and exchanging water space in breast tumors using positron emission tomography: a rapid and noninvasive dynamic method Cancer Research 52 1592 1597
64. C. J. Hoekstra S. G. Stroobants O. S. Hoekstra E. F. Smit J. F. Vansteenkiste A. A. Lammertsma 2002 Measurement of perfusion in stage IIIA-N2 non-small cell lung cancer using H(2)(15)O and positron emission tomography Clinical Cancer Research 8 2109 2115
65. P. Wells T. Jones P. Price 2003 Assessment of inter- and intrapatient variability in C15O2 positron emission tomography measurements of blood flow in patients with intra-abdominal cancers Clinical Cancer Research 9 6350 6356
66. H. L. Anderson J. T. Yap M. P. Miller A. Robbins T. Jones P. M. Price 2003 Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate Journal of Clinical Oncology 21 2823 2830
67. H. Anderson J. T. Yap P. Wells M. P. Miller D. Propper P. Price 2003 Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane British Journal of Cancer 89 262 267
68. P. N. Lara Jr. D. I. Quinn K. Margolin F. J. Meyers J. Longmate P. Frankel 2003 SU5416 plus interferon alpha in advanced renal cell carcinoma: a phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition Clinical Cancer Research 9 4772 4781
69. K. D. Miller S. E. Soule C. Calley R. E. Emerson G. D. Hutchins K. Kopecky 2005 Randomized phase II trial of the anti-angiogenic potential of doxorubicin and docetaxel; primary chemotherapy as Biomarker Discovery Laboratory Breast Cancer Research and Treatment 89 187 197
70. N. Gupta A. Saleem B. Kotz S. Osman E. O. Aboagye R. Phillips 2006 Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients Clinical Cancer Research 12 3115 3123
71. M. Bruehlmeier U. Roelcke P. A. Schubiger S. M. Ametamey 2004 Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O Journal of Nuclear Medicine 45 1851 1859
72. E. M. Stokely E. Sveinsdottir N. A. Lassen P. Rommer 1980 A single photon dynamic computer assisted tomograph (DCAT) for imaging brain function in multiple cross sections Journal of Computer Assisted Tomography 4 230 240
73. H. Namba M. Yanagisawa N. Yui T. Togawa F. Kinoshita Y. Iwadate 1996 Quantifying brain tumor blood flow by the microsphere model with N-isopropyl-p-[123I] iodoamphetamine super-early SPECT Annals of Nuclear Medicine 10 161 164
74. J. C. Andrews S. C. Walker-Andrews J. E. Juni S. Warber W. D. Ensminger 1989 Modulation of liver tumor blood flow with hepatic arterial epinephrine: a SPECT study Radiology 173 645 647
75. F. Iannotti 1992 Functional imaging of blood brain barrier permeability by single photon emission computerised tomography and positron emission tomography Advances & Technical Standards in Neurosurgery 19 103 119
76. Y. Seo S. Fukuoka J. Nakagawara M. Takanashi K. Suematsu J. Nakamura 1997 Early effects of gamma knife radiosurgery on brain metastases: assessment by 201TlCl SPECT and 99mTc-DTPA-human serum albumin SPECT Neurologia Medico-Chirurgica 37 25 30
77. K. Ishiyama N. Tomura K. Okada H. Nagasawa R. Sashi K. Sasaki 2005 Evaluating benign and malignant musculoskeletal lesions with radionuclide angiography and SPECT using Tc-99m MIBI Clinical Nuclear Medicine 30 598 603
78. D. Groshar A. J. McEwan M. B. Parliament R. C. Urtasun L. E. Golberg M. Hoskinson 1993 Imaging tumor hypoxia and tumor perfusion Journal of Nuclear Medicine 34 885 888
79. K. Ohno K. D. Pettigrew S. I. Rapoport 1978 Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat American Journal of Physiology 235 H299 H307
80. D. V. Sahani S. P. Kalva L. M. Hamberg P. F. Hahn C. G. Willett S. Saini 2005 Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations Radiology 234 785 792
81. S. Bisdas M. Baghi A. Smolarz N. C. Pihno T. Lehnert R. Knecht 2007 Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrast-enhanced computed tomography studies Investigative Radiology 42 172 179
82. D. Gandhi E. G. Hoeffner R. C. Carlos I. Case S. K. Mukherji 2003 Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract. Initial results Journal of Computer Assisted Tomography 27 687 693
83. K. A. Miles D. A. Leggett B. B. Kelley M. P. Hayball R. Sinnatamby I. Bunce 1998 In vivo assessment of neovascularization of liver metastases using perfusion CT British Journal of Radiology 71 276 281
84. P. E. Dugdale K. A. Miles I. Bunce B. B. Kelley D. A. Leggett 1999 CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response Journal of Computer Assisted Tomography 23 540 547
85. Q. S. Ng V. Goh H. Fichte E. Klotz P. Fernie M. I. Saunders 2006 Lung cancer perfusion at multi-detector row CT: Reproducibility of whole tumor quantitative measurements Radiology 239 547 553
86. V. Goh S. Halligan J. A. Hugill P. Bassett C. I. Bartram 2005 Quantitative assessment of colorectal cancer perfusion using MDCT: inter- and intraobserver agreement AJR, American Journal of Roentgenology 185 225 231
87. V. Goh S. Halligan J. A. Hugill L. Gartner C. I. Bartram V. Goh 2005 Quantitative colorectal cancer perfusion measurement using dynamic contrast-enhanced multidetector-row computed tomography: Effect of acquisition time and implications for protocols Journal of Computer Assisted Tomography 29 59 63
88. M. I. Koukourakis I. Mavanis G. Kouklakis M. Pitiakoudis G. Minopoulos C. Manolas 2007 Early antivascular effects of bevacizumab anti-VEGF monoclonal antibody on colorectal carcinomas assessed with functional CT imaging American Journal of Clinical Oncology 30 315 318
89. D. G. McNeel J. Eickhoff F. T. Lee D. M. King D. Alberti J. P. Thomas 2005 Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion Clinical Cancer Research 11 7851 7860
90. J. A. Johnson T. A. Wilson 1966 A model for capillary exchange American Journal of Physiology 210 1299 1303
91. K. S. St. Lawrence T. Y. Lee 1998 An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: I. Theoretical derivation Journal of Cerebral Blood Flow and Metabolism 18 1365 1377
92. Clark, J. W., Neuman, M. R., Olson, W. H., Peura, R. A., Primiano, F. P., Siedband, M. P., et al. (1998). Medical instrumentation (3rd ed.). New York: Wiley.
93. S. Tanaka T. Kitamura M. Fujita K. Nakanishi S. Okuda 1990 Color Doppler flow imaging of liver tumors AJR, American Journal of Roentgenology 154 509 514
94. T. Bourne S. Campbell C. Steer M. I. Whitehead W. P. Collins 1989 Transvaginal colour flow imaging: a possible new screening technique for ovarian cancer BMJ 299 1367 1370
95. J. M. Rubin R. O. Bude P. L. Carson R. L. Bree R. S. Adler 1994 Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US Radiology 190 853 856
96. R. Gramiak P. M. Shah 1968 Echocardiography of the aortic root Investigative Radiology 3 356 366
97. M. J. Blomley J. C. Cooke E. C. Unger M. J. Monaghan D. O. Cosgrove 2001 Microbubble contrast agents: a new era in ultrasound BMJ 322 1222 1225
98. M. Lamuraglia N. Lassau J. R. Garbay M. C. Mathieu R. Rouzier S. Jaziri 2005 Doppler US with perfusion software and contrast medium injection in the early evaluation of radiofrequency in breast cancer recurrences: a prospective phase II study European Journal of Radiology 56 376 381
99. M. H. Chaudhari F. Forsberg A. Voodarla F. N. Saikali S. Goonewardene L. Needleman 2000 Breast tumor vascularity identified by contrast enhanced ultrasound and pathology: initial results Ultrasonics 38 105 109
100. F. Piscaglia F. Corradi M. Mancini F. Giangregorio S. Tamberi G. Ugolini 2007 Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer BMC Cancer 7 171
101. W. Yang M. H. Chen K. Yan W. Wu Y. Dai H. Zhang 2007 Differential diagnosis of non-functional islet cell tumor and pancreatic carcinoma with sonography European Journal of Radiology 62 342 351
102. M. Bertolotto G. Pozzato L. S. Croce F. Nascimben C. Gasparini M. A. Cova 2006 Blood flow changes in hepatocellular carcinoma after the administration of thalidomide assessed by reperfusion kinetics during microbubble infusion: preliminary results Investigative Radiology 41 15 21
103. Hertz, C. H. (1981). Fourth European Congress on Ultrasound in Medicine, Dubrovnik.
104. Dymling, S., Persson, H. W., & Hertz, C. H. (1982). The measurement of blood perfusion in tissue. Fifth World Congress of Ultrasound in Medicine and Biology, Brighton, UK.
105. K. Wei A. R. Jayaweera S. Firoozan A. Linka D. M. Skyba S. Kaul 1998 Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion Circulation 97 473 483
106. E. C. Unger T. O. Matsunaga T. McCreery P. Schumann R. Sweitzer R. Quigley 2002 Therapeutic applications of microbubbles European Journal of Radiology 42 160 168
107. E. C. Unger E. Hersh M. Vannan T. O. Matsunaga T. McCreery 2001 Local drug and gene delivery through microbubbles Progress in Cardiovascular Diseases 44 45 54
108. M. A. Borden G. V. Martinez J. Ricker N. Tsvetkova M. Longo R. J. Gillies 2006 Lateral phase separation in lipid-coated microbubbles Langmuir 22 4291 4297
109. M. A. Borden C. F. Caskey E. Little R. J. Gillies K. W. Ferrara 2007 DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles Langmuir 23 9401 9408
110. K. Sokolov J. Aaron B. Hsu D. Nida A. Gillenwater M. Follen 2003 Optical systems for in vivo molecular imaging of cancer Technology in Cancer Research & Treatment 2 491 504
111. H. O. McDevitt A. H. Coons 1964 Methods for preparation of fluorescent proteins Methods in Medical Research 10 142 148
112. A. H. Coons H. J. Creech R. N. Jones 1941 Immunological properties of an antibody containing a fluorescent group Proceedings of The Society for Experimental Biology and Medicine 42 200 202
113. Murphy, D. B. (2001). Fundamentals of light microscopy and electronic imaging (1st ed.). New York, NY: Wiley.
114. R. Weissleder U. Mahmood 2001 Molecular imaging Radiology 219 316 333
115. R. T. Sadikot T. S. Blackwell 2005 Bioluminescence imaging Proceedings of the American Thoracic Society 2 537 540
116. ClinicalTrials.gov. http://clinicaltrials.gov/. In.
117. V. Ntziachristos B. Chance 2001 Probing physiology and molecular function using optical imaging: applications to breast cancer Breast Cancer Research 3 41 46
118. V. Ntziachristos A. G. Yodh M. Schnall B. Chance 2000 Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement Proceedings of the National Academy of Sciences of the United States of America 97 2767 2772
119. E. B. Brown R. B. Campbell Y. Tsuzuki L. Xu P. Carmeliet D. Fukumura 2001 In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy Nature Medicine 7 864 868 [erratum appears in Nat Med 2001 Sep;7(9):1069]
120. G. M. Tozer V. E. Prise J. Wilson M. Cemazar S. Shan M. W. Dewhirst 2001 Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability Cancer Research 61 6413 6422
121. N. Z. Wu B. Klitzman G. Rosner D. Needham M. W. Dewhirst 1993 Measurement of material extravasation in microvascular networks using fluorescence video-microscopy Microvascular Research 46 231 253
122. Hoang, B. H., Dyke, J. P., Koutcher, J. A., Huvos, A. G., Mizobuchi, H., Mazza, B. A., et al. (2004). VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. Clinical Orthopaedics and Related Research, 426, 32-38.
123. M. Rijpkema J. H. Kaanders F. B. Joosten A. J. van der Kogel A. Heerschap 2001 Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors Journal of Magnetic Resonance Imaging 14 457 463
124. C. Hayes A. R. Padhani M. O. Leach 2002 Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging NMR in Biomedicine 15 154 163
125. K. L. Li X. P. Zhu D. R. Checkley J. J. Tessier V. F. Hillier J. C. Waterton 2003 Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data British Journal of Radiology 76 39 50
126. M. V. Knopp E. Weiss H. P. Sinn J. Mattern H. Junkermann J. Radeleff 1999 Pathophysiologic basis of contrast enhancement in breast tumors Journal of Magnetic Resonance Imaging 10 260 266
127. K. Turetschek A. Preda V. Novikov R. C. Brasch H. J. Weinmann P. Wunderbaldinger 2004 Tumor microvascular changes in antiangiogenic treatment: assessment by magnetic resonance contrast media of different molecular weights Journal of Magnetic Resonance Imaging 20 138 144
128. H. J. Raatschen Y. Fu D. M. Shames M. F. Wendland R. C. Brasch 2006 Magnetic resonance imaging enhancement of normal tissues and tumors using macromolecular Gd-based cascade polymer contrast agents: preclinical evaluations Investigative Radiology 41 860 867
129. B. F. Jordan M. Runquist N. Raghunand R. J. Gillies W. R. Tate G. Powis 2005 The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging Clinical Cancer Research 11 529 536
130. R. J. Gillies N. Raghunand G. S. Karczmar Z. M. Bhujwalla 2002 MRI of the tumor microenvironment Journal of Magnetic Resonance Imaging 16 430 450 erratum appears in J Magn Reson Imaging 2002 Dec;16(6
131. P. S. Tofts G. Brix D. L. Buckley J. L. Evelhoch E. Henderson M. V. Knopp 1999 Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols Journal of Magnetic Resonance Imaging 10 223 232
132. C. S. Landis X. Li F. W. Telang P. E. Molina I. Palyka G. Vetek 1999 Equilibrium transcytolemmal water-exchange kinetics in skeletal muscle in vivo Magnetic Resonance in Medicine 42 467 478
133. C. Yang G. S. Karczmar M. Medved W. M. Stadler 2007 Multiple reference tissue method for contrast agent arterial input function estimation Magnetic Resonance in Medicine 58 1266 1275
134. S. Kim H. Quon L. A. Loevner M. A. Rosen L. Dougherty A. M. Kilger 2007 Transcytolemmal water exchange in pharmacokinetic analysis of dynamic contrast-enhanced MRI data in squamous cell carcinoma of the head and neck Journal of Magnetic Resonance Imaging 26 1607 1617
135. A. Z. Faranesh D. L. Kraitchman E. R. McVeigh 2006 Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent Magnetic Resonance in Medicine 55 1114 1123
136. Eyal, E., & Degani, H. (2008). Model-based and model-free parametric analysis of breast dynamic-contrast-enhanced MRI. NMR in Biomedicine. DOI 10.1002/nbm.1221.
137. M. O. Leach K. M. Brindle J. L. Evelhoch J. R. Griffiths M. R. Horsman A. Jackson 2003 Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials British Journal of Radiology 76 Spec No 1 S87 S91
138. A. Tandle D. G. Blazer III S. K. Libutti 2008 Antiangiogenic gene therapy of cancer: Recent developments Journal of Translational Medicine 2 22
139. G. E. Palade 1960 Transport in quanta across the endothelium of blood capillaries Anatomical Record 136 254
140. S. Kohn J. A. Nagy H. F. Dvorak A. M. Dvorak 1992 Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels Laboratory Investigation 67 596 607
141. M. Bendayan E. A. Rasio 1997 Evidence of a tubular system for transendothelial transport in arterial capillaries of the rete mirabile Journal of Histochemistry and Cytochemistry 45 1365 1378
142. M. Simionescu N. Simionescu 1991 Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology Cell Biology Reviews 25 5 78
143. M. Simionescu A. Gafencu F. Antohe 2002 Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey Microscopy Research and Technique 57 269 288
144. D. Mehta A. B. Malik 2006 Signaling mechanisms regulating endothelial permeability Physiological Reviews 86 279 367
145. R. R. Bruns G. E. Palade 1968 Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries Journal of Cell Biology 37 277 299
146. R. R. Bruns G. E. Palade 1968 Studies on blood capillaries. I. General organization of blood capillaries in muscle Journal of Cell Biology 37 244 276
147. T. Okamoto A. Schlegel P. E. Scherer M. P. Lisanti 1998 Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane Journal of Biological Chemistry 273 5419 5422
148. M. Simionescu N. Simionescu G. E. Palade 1975 Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature Journal of Cell Biology 67 863 885
149. A. M. Dvorak S. Kohn E. S. Morgan P. Fox J. A. Nagy H. F. Dvorak 1996 The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation Journal of Leukocyte Biology 59 100 115
150. P. Kumar J. F. Timoney 2005 Histology, immunohistochemistry and ultrastructure of the equine palatine tonsil Anatomia, Histologia, Embryologia: Veterinary Medicine Series C 34 192 198
151. P. Kumar J. F. Timoney 2005 Histology and ultrastructure of the equine lingual tonsil. II. Lymphoid tissue and associated high endothelial venules Anatomia, Histologia, Embryologia: Veterinary Medicine Series C 34 98 104
152. R. A. Caruso G. Speciale A. Inferrera L. Rigoli C. Inferrera 2001 Ultrastructural observations on the microvasculature in advanced gastric carcinomas Histology and Histopathology 16 785 792
153. D. Feng J. A. Nagy J. Hipp H. F. Dvorak A. M. Dvorak 1996 Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin Journal of Experimental Medicine 183 1981 1986
154. R. D. Minshall W. C. Sessa R. V. Stan R. G. Anderson A. B. Malik 2003 Caveolin regulation of endothelial function American Journal of Physiology-Lung Cellular and Molecular Physiology 285 L1179 L1183
155. D. Feng J. A. Nagy H. F. Dvorak A. M. Dvorak 2002 Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals Microscopy Research and Technique 57 289 326
156. A. Hormigo P. H. Gutin S. Rafii 2007 Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers Cancer Cell 11 6 8
157. T. T. Batchelor A. G. Sorensen E. di Tomaso W. T. Zhang D. G. Duda K. S. Cohen 2007 AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients Cancer Cell 11 83 95
158. P. Marzola A. Degrassi L. Calderan P. Farace E. Nicolato C. Crescimanno 2005 Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma Clinical Cancer Research 11 5827 5832
159. G. Liu H. S. Rugo G. Wilding T. M. McShane J. L. Evelhoch C. Ng 2005 Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study Journal of Clinical Oncology 23 5464 5473
160. A. L. Thomas B. Morgan M. A. Horsfield A. Higginson A. Kay L. Lee 2005 Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer Journal of Clinical Oncology 23 4162 4171
161. B. Morgan A. L. Thomas J. Drevs J. Hennig M. Buchert A. Jivan 2003 Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies Journal of Clinical Oncology 21 3955 3964
162. P. Traxler P. R. Allegrini R. Brandt J. Brueggen R. Cozens D. Fabbro 2004 AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity Cancer Research 64 4931 4941
163. D. Checkley J. J. Tessier J. Kendrew J. C. Waterton S. R. Wedge 2003 Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours British Journal of Cancer 89 1889 1895
164. G. C. Jayson J. Zweit A. Jackson C. Mulatero P. Julyan M. Ranson 2002 Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies Journal of the National Cancer Institute 94 1484 1493
165. J. P. Eder Jr. J. G. Supko J. W. Clark T. A. Puchalski R. Garcia-Carbonero D. P. Ryan 2002 Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily Journal of Clinical Oncology 20 3772 3784