Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O

Journal of Nuclear Medicine

Volumn 45, Issue 11, 2004, Pages 1851-1859

  Bruehlmeier, Matthias ^a,b   Roelcke, Ulrich ^b   Schubiger, Pius A ^a   Ametamey, Simon Mensah ^a  

^a ETH Zurich   (Switzerland)

^b CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

18F fluoromisonidazole; Brain tumor; Hypoxia; PET

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; DEXAMETHASONE; TEMOZOLOMIDE; WATER O 15; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; DIAGNOSTIC AGENT; DRUG DERIVATIVE; MISONIDAZOLE; OXYGEN; RADIOPHARMACEUTICAL AGENT; WATER;

ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; BRAIN TUMOR; CLINICAL ARTICLE; DISTRIBUTION VOLUME; FEMALE; GLIOBLASTOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOXIA; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MENINGIOMA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; BLOOD FLOW VELOCITY; BRAIN; BRAIN HYPOXIA; CLINICAL TRIAL; IMAGE SUBTRACTION; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; VASCULARIZATION;

ADULT; AGED; BLOOD FLOW VELOCITY; BRAIN; BRAIN NEOPLASMS; FEMALE; HUMANS; HYPOXIA, BRAIN; MALE; MIDDLE AGED; MISONIDAZOLE; OXYGEN RADIOISOTOPES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBTRACTION TECHNIQUE; WATER;

EID: 16544388645     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Nias AHW. An Introduction to Radiobiology. 2nd ed. London, UK: Wiley & Sons; 1998.
2. Gray LH, Conger AD, Ebert M, et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953;26:638-648.
3. Airley RE, Monaghan JE, Stratford IJ. Hypoxia and disease: opportunities for novel diagnostic and therapeutic prodrug strategies. Pharm J. 2000;264:666-673.
4. Ikeda E, Achen MG, Breier G, et al. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem. 1995;270:19761-19766.
5. Kleihues P, Cavanee WK. Tumours of the nervous system. Pathology and Genetics: World Health Organization Classification of Tumors. Lyon, France: IARC Press; 2000.
6. Bernsen HJ, Rijken PF, Peters H, et al. Hypoxia in a human intracerebral glioma model. J Neurosurg. 2000;93:449-454.
7. Rijken PF, Bernsen HJ, Peters JP, et al. Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis. Int J Radiat Oncol Biol Phys. 2000;48:571-582.
8. Chapman JD, Engelhardt EL, Stobbe CC, et al. Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays. Radiother Oncol. 1998;46:229-237.
9. Rasey JS, Koh WJ, Grierson JR, et al. Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia. Int J Radiat Oncol Biol Phys. 1989;17:985-991.
10. Lewis J, Laforest R, Buettner T, et al. Copper-64-diacetyl-bis(N4- methylthiosemicarbazone): an agent for radiotherapy. Proc Natl Acad Sci USA. 2001;98:1206-1211.
11. 18F-FETNIM: a potential marker for PET. J Nucl Med. 2001;42:1397-1404.
12. 18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure. Appl Radiat Isot. 2001;54:73-80.
13. 18F]FETNIM) and PET using the tumour-to-plasma ratio. Eur J Nucl Med Mol Imaging. 2003;30:101-108.
14. 18F]fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys. 1996;36:417-428.
15. Whitmore GF, Varghese AJ. The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. Biochem Pharmacol. 1986;35:97-103.
16. Valk PE, Mathis CA, Prados MD, et al. Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole. J Nucl Med. 1992;33:2133-2137.
17. Leenders KL. PET: blood flow and oxygen consumption in brain tumors. J Neurooncol. 1994;22:269-273.
18. 18F] fluoromisonidazole. Appl Radiat Isot. 1993;44:1085-1091.
19. Mikolajczyk K, Szabatin M, Rudnicki P, et al. A JAVA environment for medical image data analysis: initial application for brain PET quantitation. Med Inform (Lond). 1998;23:207-214.
20. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990;10:740-747.
21. Brat DJ, Castellano-Sanchez AA, Hunter SB, et al. Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res. 2004;64:920-927.
22. 18F]fluoromisonidazole (FMISO). Nucl Med Biol. 2002;29:191-197.
23. Collingridge DR, Piepmeier JM, Rockwell S, et al. Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue. Radiother Oncol. 1999;53:127-131.
24. Zagzag D, Zhong H, Scalzitti JM, et al. Expression of hypoxia-inducible factor 1-alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000;88:2606-2618.
25. Gross MW, Karbach U, Groebe K, et al. Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int J Cancer. 1995;61:567-573.
26. 18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia. J Nucl Med. 1999;40:1072-1079.
27. Martin GV, Caldwell JH, Graham MM, et al. Noninvasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography. J Nucl Med. 1992;33:2202-2208.
28. Groshar D, McEwan AJ, Parliament MB, et al. Imaging tumor hypoxia and tumor perfusion. J Nucl Med. 1993;34:885-888.
29. Vajkoczy P, Menger MD. Vascular microenvironment in gliomas. J Neurooncol. 2000;50:99-108.
30. Marquardt DW. An algorithm for least squares estimation of nonlinear parameters. J Soc Industr Appl Math. 1963;11:431-441.
31. Hawkins RA, Phelps ME, Huang SC. Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: studies in human brain tumors with PET. J Cereb Blood Flow Metab. 1986;6:170-183.
32. Casciari JJ, Graham MM, Rasey JS. A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data. Med Phys. 1995;22:1127-1139.
33. Rasey JS, Grunbaum Z, Magee S, et al. Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res. 1987;111:292-304.