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Volumn 59, Issue 1, 1996, Pages 100-115

The vesiculo-vacuolar organelle (VVO): A distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

Author keywords

Cytokines; Electron microscopy; Macromolecular electron dense tracers; Transendothelial transport; Tumor vasculature; Vascular permeability

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL ORGANELLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FEMALE; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL;

EID: 0030045180     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.1.100     Document Type: Article
Times cited : (248)

References (38)
  • 1
    • 0023885893 scopus 로고
    • Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas
    • Brown, L.F., Asch, B., Harvey, V.S., Buchinski, B., Dvorak, H.F. (1988) Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas. Cancer Res. 48, 1920-1925.
    • (1988) Cancer Res. , vol.48 , pp. 1920-1925
    • Brown, L.F.1    Asch, B.2    Harvey, V.S.3    Buchinski, B.4    Dvorak, H.F.5
  • 2
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak, H.F. (1986) Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650-1659.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 3
    • 0018413341 scopus 로고
    • Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of celular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression
    • Dvorak, H.F., Dvorak, A.M., Manseau, E.J., Wiberg, L., Churchill, W.H. (1979) Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of celular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression. J. Natl. Cancer Inst. 62, 1459-1472.
    • (1979) J. Natl. Cancer Inst. , vol.62 , pp. 1459-1472
    • Dvorak, H.F.1    Dvorak, A.M.2    Manseau, E.J.3    Wiberg, L.4    Churchill, W.H.5
  • 5
    • 0021152778 scopus 로고
    • Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas
    • Dvorak, H.F., Harvey, V.S., McDonagh, J. (1984) Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas. Cancer Res, 44, 3348-3354.
    • (1984) Cancer Res , vol.44 , pp. 3348-3354
    • Dvorak, H.F.1    Harvey, V.S.2    McDonagh, J.3
  • 6
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak, H.F., Nagy, J.A., Dvorak, J.T., Dvorak, A.M. (1988) Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am. J. Pathol. 133, 95-109.
    • (1988) Am. J. Pathol. , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3    Dvorak, A.M.4
  • 8
    • 0022495733 scopus 로고
    • Microvascular permeability of normal and neoplastic tissues
    • Gerlowski, L.E., Jain, R.K. (1986) Microvascular permeability of normal and neoplastic tissues. Microvasc. Res. 31, 288-305.
    • (1986) Microvasc. Res. , vol.31 , pp. 288-305
    • Gerlowski, L.E.1    Jain, R.K.2
  • 9
    • 0022653255 scopus 로고
    • Differential macromolecular leakage from the vasculature of tumors
    • Heuser, L.S., Miller, F.N. (1986) Differential macromolecular leakage from the vasculature of tumors. Cancer 57, 461-464.
    • (1986) Cancer , vol.57 , pp. 461-464
    • Heuser, L.S.1    Miller, F.N.2
  • 10
    • 0021169796 scopus 로고
    • Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors
    • O'Connor, S.W., Bale, W.F. (1984) Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors. Cancer Res. 44, 3719-3723.
    • (1984) Cancer Res. , vol.44 , pp. 3719-3723
    • O'Connor, S.W.1    Bale, W.F.2
  • 13
    • 0015364217 scopus 로고
    • The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma
    • Underwood, J.C., Carr, I. (1972) The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma. J. Pathol. 107, 157-166.
    • (1972) J. Pathol. , vol.107 , pp. 157-166
    • Underwood, J.C.1    Carr, I.2
  • 14
    • 0025981665 scopus 로고
    • Structure of solid tumors and their vasculature: Implications for therapy with monoclonal antibodies
    • Dvorak, H.F., Nagy, J.A., Dvorak, A.M. (1991) Structure of solid tumors and their vasculature: Implications for therapy with monoclonal antibodies. Cancer Cells 3, 77-85.
    • (1991) Cancer Cells , vol.3 , pp. 77-85
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, A.M.3
  • 15
    • 0026459937 scopus 로고
    • Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels
    • Kohn, S., Nagy, J.A., Dvorak, H.F., Dvorak, A.M. (1992) Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. Lab. Invest. 67, 596-607.
    • (1992) Lab. Invest. , vol.67 , pp. 596-607
    • Kohn, S.1    Nagy, J.A.2    Dvorak, H.F.3    Dvorak, A.M.4
  • 16
    • 0013895415 scopus 로고
    • The early stages of absorption of injected horseradish peroxidase in the proximal tubules of the mouse kidney: Ultrastructural cytochemistry by a new technique
    • Graham, R.C., Jr., Karnovsky, M.J. (1966) The early stages of absorption of injected horseradish peroxidase in the proximal tubules of the mouse kidney: Ultrastructural cytochemistry by a new technique. J. Histochem. Cytochem. 14, 291-302.
    • (1966) J. Histochem. Cytochem. , vol.14 , pp. 291-302
    • Graham Jr., R.C.1    Karnovsky, M.J.2
  • 18
    • 0014301569 scopus 로고
    • Structural modulations of plasmalemmal vesicles
    • Palade, G.E., Bruns, R.R. (1968) Structural modulations of plasmalemmal vesicles. J. Cell Biol. 37, 633-649.
    • (1968) J. Cell Biol. , vol.37 , pp. 633-649
    • Palade, G.E.1    Bruns, R.R.2
  • 19
    • 0014289538 scopus 로고
    • Studies on blood capillaries. I. General organization of blood capillaries in muscle
    • Bruns, R.R., Palade, G.E. (1968) Studies on blood capillaries. I. General organization of blood capillaries in muscle. J. Cell Biol. 37, 244-276.
    • (1968) J. Cell Biol. , vol.37 , pp. 244-276
    • Bruns, R.R.1    Palade, G.E.2
  • 20
    • 0016640970 scopus 로고
    • Permeability of muscle capillaries to small heme-peptides. Evidence for the existence of patent transendothelial channels
    • Simionescu, N., Simionescu, M., Palade, G.E. (1975) Permeability of muscle capillaries to small heme-peptides. Evidence for the existence of patent transendothelial channels. J. Cell Biol. 64, 586-607.
    • (1975) J. Cell Biol. , vol.64 , pp. 586-607
    • Simionescu, N.1    Simionescu, M.2    Palade, G.E.3
  • 21
    • 0022551377 scopus 로고
    • Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: Receptor-mediated transcytosis
    • Ghitescu, L., Fixman, A., Simionescu, M., Simionescu, N. (1986) Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: Receptor-mediated transcytosis. J. Cell Biol. 102, 1304-1311.
    • (1986) J. Cell Biol. , vol.102 , pp. 1304-1311
    • Ghitescu, L.1    Fixman, A.2    Simionescu, M.3    Simionescu, N.4
  • 22
    • 0024110161 scopus 로고    scopus 로고
    • Binding and transcytosis of glycoalbumin by the microvascular endothelium of the murine myocardium: Evidence that glycoalbumin behaves as a bifunctional ligand
    • 988
    • Predescu, D., Simionescu, M., Simionescu, N., Palade, G.E. (988) Binding and transcytosis of glycoalbumin by the microvascular endothelium of the murine myocardium: Evidence that glycoalbumin behaves as a bifunctional ligand. J. Cell Biol. 107, 1729-1738.
    • J. Cell Biol. , vol.107 , pp. 1729-1738
    • Predescu, D.1    Simionescu, M.2    Simionescu, N.3    Palade, G.E.4
  • 23
    • 0015255269 scopus 로고
    • Uptake of horseradish peroxidase by guinea pig basophilic leukocytes
    • Dvorak, A.M., Dvorak, H.F., Karnovsky, M.J. (1972) Uptake of horseradish peroxidase by guinea pig basophilic leukocytes. Lab. Invest. 26, 27-39.
    • (1972) Lab. Invest. , vol.26 , pp. 27-39
    • Dvorak, A.M.1    Dvorak, H.F.2    Karnovsky, M.J.3
  • 24
    • 0005504852 scopus 로고
    • Permeability characteristics of the microcirculation
    • (N.A. Martmortillaro, ed.), Academic Press, New York
    • Granger, D.N., Perry, M.A. (1983) Permeability characteristics of the microcirculation. In The Physiology and Pharmacology of the Microcirculation, Vol. 1 (N.A. Martmortillaro, ed.), Academic Press, New York, 157-208.
    • (1983) The Physiology and Pharmacology of the Microcirculation , vol.1 , pp. 157-208
    • Granger, D.N.1    Perry, M.A.2
  • 25
    • 0002975217 scopus 로고
    • Passage of dextran molecules across the blood-lymph barrier
    • Grotte, G. (1956) Passage of dextran molecules across the blood-lymph barrier. Acta Chirurgica Scandinavian [Suppl] 211, 1-84.
    • (1956) Acta Chirurgica Scandinavian [Suppl] , vol.211 , pp. 1-84
    • Grotte, G.1
  • 26
    • 0001203922 scopus 로고
    • Exchange of substances through the capillary walls
    • (W.F. Hamilton and P. Dow, eds.), American Physiological Society, Washington, DC
    • Landis, E.M., Pappenheimer, J.R. (1963) Exchange of substances through the capillary walls. In Handbook of Physiology - Section 2: Circulation, Vol. II (W.F. Hamilton and P. Dow, eds.), American Physiological Society, Washington, DC, 961-1034.
    • (1963) Handbook of Physiology - Section 2: Circulation , vol.2 , pp. 961-1034
    • Landis, E.M.1    Pappenheimer, J.R.2
  • 27
    • 0028147336 scopus 로고
    • Transport of macromolecules across microvascular walls: The two-pore theory
    • Rippe, B., Haraldsson, B. (1994) Transport of macromolecules across microvascular walls: The two-pore theory. Physiol. Rev. 74, 163-219.
    • (1994) Physiol. Rev. , vol.74 , pp. 163-219
    • Rippe, B.1    Haraldsson, B.2
  • 28
    • 0000855817 scopus 로고
    • Fine structure of blood capillaries
    • Palade, G.E. (1953) Fine structure of blood capillaries. J. Appl. Physiol. 24, 1424.
    • (1953) J. Appl. Physiol. , vol.24 , pp. 1424
    • Palade, G.E.1
  • 29
    • 0014283669 scopus 로고
    • Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries
    • Bruns, R.R., Palade, G.E. (1968) Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries. J. Cell Biol. 37, 277-299.
    • (1968) J. Cell Biol. , vol.37 , pp. 277-299
    • Bruns, R.R.1    Palade, G.E.2
  • 30
    • 0041110797 scopus 로고
    • Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface
    • Bundgaard, M., Frøkjaer-Jensen, J., Crone, C. (1979) Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface. Proc. Natl. Acad. Sci. USA 76, 6439-6442.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 6439-6442
    • Bundgaard, M.1    Frøkjaer-Jensen, J.2    Crone, C.3
  • 31
    • 0019274075 scopus 로고
    • Three-dimensional organization of plasmalemmal vesicles in endothelial cells. An analysis by serial sectioning of frog mesenteric capillaries
    • Frøkjaer-Jensen, J. (1980) Three-dimensional organization of plasmalemmal vesicles in endothelial cells. An analysis by serial sectioning of frog mesenteric capillaries. J. Ultrastruct. Res. 73, 9-20.
    • (1980) J. Ultrastruct. Res. , vol.73 , pp. 9-20
    • Frøkjaer-Jensen, J.1
  • 32
    • 0014139605 scopus 로고
    • The ultrastructural basis of capillary permeability studied with peroxidase as a tracer
    • Karnovsky, M.J. (1967) The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol. 35, 213-236.
    • (1967) J. Cell Biol. , vol.35 , pp. 213-236
    • Karnovsky, M.J.1
  • 33
    • 0001929073 scopus 로고
    • The microvascular endothelium revisited
    • (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York
    • Palade, G.E. (1988) The microvascular endothelium revisited. In Endothelial Cell Biology in Health and Disease (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York, 3-22.
    • (1988) Endothelial Cell Biology in Health and Disease , pp. 3-22
    • Palade, G.E.1
  • 34
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D.R., Galli, S.J., Dvorak, A.M., Perruzzi, C.A., Harvey, V.S., Dvorak, H.F. (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 35
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • Senger, D.R., Perruzzi, C.A., Feder, J., Dvorak, H.F. (1986) A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 46, 5629-5632.
    • (1986) Cancer Res. , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.F.4
  • 37
    • 0025194878 scopus 로고
    • Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
    • Senger, D.R., Connolly, D.T., Van De Water, L., Feder, J., Dvorak, H.F. (1990) Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50, 1774-1778.
    • (1990) Cancer Res. , vol.50 , pp. 1774-1778
    • Senger, D.R.1    Connolly, D.T.2    Van De Water, L.3    Feder, J.4    Dvorak, H.F.5
  • 38
    • 0028933926 scopus 로고
    • Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium
    • Qu-Hong, Nagy, J.A., Senger, D.R., Dvorak, H.F., Dvorak, A.M. (1995) Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium. J. Histochem. Cytochem. 43, 381-389.
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 381-389
    • Qu-Hong1    Nagy, J.A.2    Senger, D.R.3    Dvorak, H.F.4    Dvorak, A.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.