Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5- substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6730-6739

  Gangjee, Aleem ^a   Jain, Hiteshkumar D ^a   McGuire, John J ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 METHYL 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; FOLIC ACID ANTAGONIST; FOLYLPOLYGLUTAMATE SYNTHASE; MERCAPTOBENZOIC ACID; METHOTREXATE; N [4 [(2 AMINO 6 METHYL 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)THIO] 2' CHLOROBENZOYL]GLUTAMIC ACID; N [4 [(2 AMINO 6 METHYL 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)THIO] 2' FLUOROBENZOYL]GLUTAMIC ACID; PEMETREXED; PYRIMIDINE DERIVATIVE; RALTITREXED; SODIUM; THIOBENZOYL 7H PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; THIOL DERIVATIVE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIAZOTIZATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HALOGENATION; HUMAN; HUMAN CELL; OXIDATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 11144221171     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040144e     Document Type: Article

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