메뉴 건너뛰기




Volumn 6, Issue 8, 2008, Pages 1293-1307

Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 27; LENS EPITHELIUM DERIVED GROWTH FACTOR; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN P52; PROTEIN P75; SYNAPTOPHYSIN; CASPASE; CASPASE 7; ISOPROTEIN; LENS EPITHELIUM-DERIVED GROWTH FACTOR; SIGNAL PEPTIDE;

EID: 52449087649     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0125     Document Type: Article
Times cited : (38)

References (64)
  • 1
    • 9244221127 scopus 로고    scopus 로고
    • Dietary antioxidants and human cancer
    • Borek C. Dietary antioxidants and human cancer. Integr Cancer Ther 2004;3:333-41.
    • (2004) Integr Cancer Ther , vol.3 , pp. 333-341
    • Borek, C.1
  • 2
    • 11144280033 scopus 로고    scopus 로고
    • Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: Targets for chemopreventive strategies
    • Pathak SK, Sharma RA, Steward WP, Mellon JK, Griffiths TR, Gescher AJ. Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies. Eur J Cancer 2005;41:61-70.
    • (2005) Eur J Cancer , vol.41 , pp. 61-70
    • Pathak, S.K.1    Sharma, R.A.2    Steward, W.P.3    Mellon, J.K.4    Griffiths, T.R.5    Gescher, A.J.6
  • 3
    • 33745234081 scopus 로고    scopus 로고
    • Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell
    • Robertso n RP, Harmon JS. Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell. Free Radic Biol Med 2006;41:177-84.
    • (2006) Free Radic Biol Med , vol.41 , pp. 177-184
    • Robertso n, R.P.1    Harmon, J.S.2
  • 4
    • 33751522909 scopus 로고    scopus 로고
    • The redox regulation of thiol dependent signaling pathways in cancer
    • Giles GI. The redox regulation of thiol dependent signaling pathways in cancer. Curr Pharm Des 2006;12:4427-43.
    • (2006) Curr Pharm Des , vol.12 , pp. 4427-4443
    • Giles, G.I.1
  • 5
    • 3042689052 scopus 로고    scopus 로고
    • Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung
    • Kinnula VL, Paakko P, Soini Y. Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung. FEBS Lett 2004;569:1-6.
    • (2004) FEBS Lett , vol.569 , pp. 1-6
    • Kinnula, V.L.1    Paakko, P.2    Soini, Y.3
  • 7
    • 0042763088 scopus 로고    scopus 로고
    • LEDGF/p75: A novel nuclear autoantigen at the crossroads of cell survival and apoptosis
    • Ganapathy V, Daniels T, Casiano CA. LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis. Autoimmun Rev 2003;2:290-7.
    • (2003) Autoimmun Rev , vol.2 , pp. 290-297
    • Ganapathy, V.1    Daniels, T.2    Casiano, C.A.3
  • 8
    • 0035987224 scopus 로고    scopus 로고
    • LEDGF, a survival factor, activates stress-related genes
    • Shinohara T, Singh DP and Fatma N. LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res 2002;21:341-58.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 341-358
    • Shinohara, T.1    Singh, D.P.2    Fatma, N.3
  • 9
    • 33644857246 scopus 로고    scopus 로고
    • Regulation of heavy subunit chain of γ-glutamylcysteine synthetase by tumor necrosis factor-α in lens epithelial cells: Role of LEDGF/p75
    • Takamura Y, Fatma N, Kubo E, Singh DP. Regulation of heavy subunit chain of γ-glutamylcysteine synthetase by tumor necrosis factor-α in lens epithelial cells: role of LEDGF/p75. Am J Physiol Cell Physiol 2006;290:C554-66.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Takamura, Y.1    Fatma, N.2    Kubo, E.3    Singh, D.P.4
  • 10
    • 0032538795 scopus 로고    scopus 로고
    • Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
    • Ge H, Si Y, Roeder RG. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J 1998;17:6723-9.
    • (1998) EMBO J , vol.17 , pp. 6723-6729
    • Ge, H.1    Si, Y.2    Roeder, R.G.3
  • 11
    • 0033916267 scopus 로고    scopus 로고
    • Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
    • Ochs RL, Muro Y, Si Y, Ge H, Chan EK, Tan EM. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol 2000;105:1211-20.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1211-1220
    • Ochs, R.L.1    Muro, Y.2    Si, Y.3    Ge, H.4    Chan, E.K.5    Tan, E.M.6
  • 12
    • 33749175924 scopus 로고    scopus 로고
    • Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations
    • Sutherland HG, Newton K, Brownstein DG, et al. Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol 2006;26:7201-10.
    • (2006) Mol Cell Biol , vol.26 , pp. 7201-7210
    • Sutherland, H.G.1    Newton, K.2    Brownstein, D.G.3
  • 13
    • 0035966103 scopus 로고    scopus 로고
    • Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress
    • Fatma N, Singh DP, Shinohara T, Chrylack LT, Jr. Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J Biol Chem 2001;276:48899-907.
    • (2001) J Biol Chem , vol.276 , pp. 48899-48907
    • Fatma, N.1    Singh, D.P.2    Shinohara, T.3    Chrylack Jr., L.T.4
  • 14
    • 3242660160 scopus 로고    scopus 로고
    • LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: Stimulation of retinoic acid production and protection from ethanol toxicity
    • Fatma N, Kubo E, Chylack LT, Jr., Shinohara T, Akagi Y, Singh DP. LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity. Am J Physiol Cell Physiol 2004;287:C508-16.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Fatma, N.1    Kubo, E.2    Chylack Jr., L.T.3    Shinohara, T.4    Akagi, Y.5    Singh, D.P.6
  • 16
    • 0034811440 scopus 로고    scopus 로고
    • LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes
    • Singh DP, Fatma N, Kimura A, Chylack LT, Jr., Shinohara T. LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun 2001;283:943-55.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 943-955
    • Singh, D.P.1    Fatma, N.2    Kimura, A.3    Chylack Jr., L.T.4    Shinohara, T.5
  • 17
    • 27744503937 scopus 로고    scopus 로고
    • The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern
    • Dellavance A, Viana VS, Leon EP, Bonfa ES, Andrade LE, Leser PG. The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol 2005;32:2144-9.
    • (2005) J Rheumatol , vol.32 , pp. 2144-2149
    • Dellavance, A.1    Viana, V.S.2    Leon, E.P.3    Bonfa, E.S.4    Andrade, L.E.5    Leser, P.G.6
  • 18
    • 1542373697 scopus 로고    scopus 로고
    • Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): What exactly are the autoantibodies trying to tell us?
    • Ganapathy V, Casiano CA. Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us? Arthritis Rheum 2004;50:684-8.
    • (2004) Arthritis Rheum , vol.50 , pp. 684-688
    • Ganapathy, V.1    Casiano, C.A.2
  • 19
    • 33744530351 scopus 로고    scopus 로고
    • HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease
    • Muro Y, Ogawa Y, Sugiura K, Tomita Y. HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. J Autoimmun 2006;26:252-7.
    • (2006) J Autoimmun , vol.26 , pp. 252-257
    • Muro, Y.1    Ogawa, Y.2    Sugiura, K.3    Tomita, Y.4
  • 20
    • 33745745419 scopus 로고    scopus 로고
    • Retroviral DNA integration: HIV and the role of LEDGF/p75
    • Ciuffi A, Bushman FD. Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet 2006;22:388-95.
    • (2006) Trends Genet , vol.22 , pp. 388-395
    • Ciuffi, A.1    Bushman, F.D.2
  • 21
    • 34047200871 scopus 로고    scopus 로고
    • Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV
    • Hombrouck A, De Rijck J, Hendrix J, et al. Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS Pathog 2007;3:e47.
    • (2007) PLoS Pathog , vol.3
    • Hombrouck, A.1    De Rijck, J.2    Hendrix, J.3
  • 23
    • 34447513231 scopus 로고    scopus 로고
    • LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
    • Shun MC, Raghavendra NK, Vandegraaff N, et al. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev 2007;21:1767-78.
    • (2007) Genes Dev , vol.21 , pp. 1767-1778
    • Shun, M.C.1    Raghavendra, N.K.2    Vandegraaff, N.3
  • 24
    • 44349171666 scopus 로고    scopus 로고
    • Role of PSIP1/LEDGF/ p75 in lentiviral infectivity and integration targeting
    • Marshall HM, Ronen K, Berry C, et al. Role of PSIP1/LEDGF/ p75 in lentiviral infectivity and integration targeting. PLoS ONE 2007;2:e1340.
    • (2007) PLoS ONE , vol.2
    • Marshall, H.M.1    Ronen, K.2    Berry, C.3
  • 25
    • 0036714175 scopus 로고    scopus 로고
    • The family of hepatoma-derived growth factor proteins: Characterization of a new member HRP-4 and classification of its subfamilies
    • Dietz F, Franken S, Yoshida K, Nakamura H, Kappler J, Gieselmann V. The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies. Biochem J 2002;366:491-500.
    • (2002) Biochem J , vol.366 , pp. 491-500
    • Dietz, F.1    Franken, S.2    Yoshida, K.3    Nakamura, H.4    Kappler, J.5    Gieselmann, V.6
  • 26
    • 0033676752 scopus 로고    scopus 로고
    • t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF)
    • Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SY, Slovak ML. t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF). Cancer Res 2000;60:6227-9.
    • (2000) Cancer Res , vol.60 , pp. 6227-6229
    • Ahuja, H.G.1    Hong, J.2    Aplan, P.D.3    Tcheurekdjian, L.4    Forman, S.Y.5    Slovak, M.L.6
  • 27
    • 27644459145 scopus 로고    scopus 로고
    • NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia
    • Grand FH, Koduru P, Cross NC, Allen SL. NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia. Leuk Res 2005;29:1469-72.
    • (2005) Leuk Res , vol.29 , pp. 1469-1472
    • Grand, F.H.1    Koduru, P.2    Cross, N.C.3    Allen, S.L.4
  • 28
    • 18744387769 scopus 로고    scopus 로고
    • Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation
    • Hussey DJ, Moore S, Nicola M, Dobrovic A. Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation. BMC Genet 2001;2:20.
    • (2001) BMC Genet , vol.2 , pp. 20
    • Hussey, D.J.1    Moore, S.2    Nicola, M.3    Dobrovic, A.4
  • 29
    • 13844298935 scopus 로고    scopus 로고
    • t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia
    • Morerio C, Acquila M, Rosanda C, et al. t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. Leuk Res 2005;29:467-70.
    • (2005) Leuk Res , vol.29 , pp. 467-470
    • Morerio, C.1    Acquila, M.2    Rosanda, C.3
  • 30
    • 0036715347 scopus 로고    scopus 로고
    • Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: Implications for autoimmunity in atopic disorders
    • Wu X, Daniels T, Molinaro C, Lilly MB, Casiano CA. Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. Cell Death Differ 2002;9:915-25.
    • (2002) Cell Death Differ , vol.9 , pp. 915-925
    • Wu, X.1    Daniels, T.2    Molinaro, C.3    Lilly, M.B.4    Casiano, C.A.5
  • 31
    • 10144237224 scopus 로고    scopus 로고
    • Antinuclear autoantibodies in prostate cancer: Immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis
    • Daniels T, Zhang J, Gutierrez I, et al. Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. Prostate 2005;62:14-26.
    • (2005) Prostate , vol.62 , pp. 14-26
    • Daniels, T.1    Zhang, J.2    Gutierrez, I.3
  • 32
    • 34047274469 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer
    • Daugaard M, Kirkegaard-Sorensen T, Ostenfeld MS, et al. Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer. Cancer Res 2007;67:2559-67.
    • (2007) Cancer Res , vol.67 , pp. 2559-2567
    • Daugaard, M.1    Kirkegaard-Sorensen, T.2    Ostenfeld, M.S.3
  • 33
    • 34249803226 scopus 로고    scopus 로고
    • LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro
    • Huang TS, Myklebust LM, Kjarland E, et al. LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. Mol Cancer 2007;6:31.
    • (2007) Mol Cancer , vol.6 , pp. 31
    • Huang, T.S.1    Myklebust, L.M.2    Kjarland, E.3
  • 34
    • 0033967955 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing
    • Singh DP, Kimura A, Chylack LT, Jr. Shinohara T. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. Gene 2000;242:265-73.
    • (2000) Gene , vol.242 , pp. 265-273
    • Singh, D.P.1    Kimura, A.2    Chylack Jr., L.T.3    Shinohara, T.4
  • 35
    • 0032239750 scopus 로고    scopus 로고
    • A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
    • Ge H, Si Y, Wolffe AP. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol Cell 1998;2:751-9.
    • (1998) Mol Cell , vol.2 , pp. 751-759
    • Ge, H.1    Si, Y.2    Wolffe, A.P.3
  • 36
    • 2942593748 scopus 로고    scopus 로고
    • Chromatin targeting of de novo DNA methyltransferases by the PWWP domain
    • Ge YZ, Pu MT, Gowher H, et al. Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J Biol Chem 2004;279:25447-54.
    • (2004) J Biol Chem , vol.279 , pp. 25447-25454
    • Ge, Y.Z.1    Pu, M.T.2    Gowher, H.3
  • 37
    • 4744366752 scopus 로고    scopus 로고
    • The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin
    • Chen T, Tsujimoto N, Li E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol 2004;24:9048-58.
    • (2004) Mol Cell Biol , vol.24 , pp. 9048-9058
    • Chen, T.1    Tsujimoto, N.2    Li, E.3
  • 39
    • 20044363955 scopus 로고    scopus 로고
    • Solution structure of the PWWP domain of the hepatoma-derived growth factor family
    • Nameki N, Tochio N, Koshiba S, et al. Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Protein Sci 2005;14:756-64.
    • (2005) Protein Sci , vol.14 , pp. 756-764
    • Nameki, N.1    Tochio, N.2    Koshiba, S.3
  • 40
    • 0036176982 scopus 로고    scopus 로고
    • The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds
    • Qiu C, Sawada K, Zhang X, Cheng X. The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol 2002;9:217-24.
    • (2002) Nat Struct Biol , vol.9 , pp. 217-224
    • Qiu, C.1    Sawada, K.2    Zhang, X.3    Cheng, X.4
  • 41
    • 33745617039 scopus 로고    scopus 로고
    • Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75
    • Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM. Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. J Mol Biol 2006;360:760-73.
    • (2006) J Mol Biol , vol.360 , pp. 760-773
    • Llano, M.1    Vanegas, M.2    Hutchins, N.3    Thompson, D.4    Delgado, S.5    Poeschla, E.M.6
  • 42
    • 33645528413 scopus 로고    scopus 로고
    • A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
    • Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman A. A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic Acids Res 2006;34:1653-75.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1653-1675
    • Turlure, F.1    Maertens, G.2    Rahman, S.3    Cherepanov, P.4    Engelman, A.5
  • 43
    • 10344221084 scopus 로고    scopus 로고
    • Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/ transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
    • Cheperanov P, Devroe E, Silver PA, Engelman A. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/ transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem 2004;279:48883-92.
    • (2004) J Biol Chem , vol.279 , pp. 48883-48892
    • Cheperanov, P.1    Devroe, E.2    Silver, P.A.3    Engelman, A.4
  • 44
    • 14244257153 scopus 로고    scopus 로고
    • Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal α-helical domain
    • Ogawa Y, Sugiura K, Watanabe A, et al. Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal α-helical domain. J Autoimmun 2004;23:221-31.
    • (2004) J Autoimmun , vol.23 , pp. 221-231
    • Ogawa, Y.1    Sugiura, K.2    Watanabe, A.3
  • 45
    • 18844429520 scopus 로고    scopus 로고
    • Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering
    • Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci 2005;118:1733-43.
    • (2005) J Cell Sci , vol.118 , pp. 1733-1743
    • Vanegas, M.1    Llano, M.2    Delgado, S.3    Thompson, D.4    Peretz, M.5    Poeschla, E.6
  • 46
    • 29044449057 scopus 로고    scopus 로고
    • DNA binding domains and nuclear localization signal of LEDGF: Contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF
    • Singh DP, Kubo E, Takamura Y, et al. DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF. J Mol Biol 2006;355:379-94.
    • (2006) J Mol Biol , vol.355 , pp. 379-394
    • Singh, D.P.1    Kubo, E.2    Takamura, Y.3
  • 47
    • 21244439380 scopus 로고    scopus 로고
    • Regulation of apoptosis by alternative pre-mRNA splicing
    • Schwerk C, Schulze-Osthoff K. Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 2005;19:1-13.
    • (2005) Mol Cell , vol.19 , pp. 1-13
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 48
    • 33645833000 scopus 로고    scopus 로고
    • Unbalanced alternative splicing and its significance in cancer
    • Venables JP. Unbalanced alternative splicing and its significance in cancer. Bioessays 2006;28:378-86.
    • (2006) Bioessays , vol.28 , pp. 378-386
    • Venables, J.P.1
  • 49
    • 0242432345 scopus 로고    scopus 로고
    • Many cuts to ruin: A comprehensive update of caspase substrates
    • Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 2003;10:76-100.
    • (2003) Cell Death Differ , vol.10 , pp. 76-100
    • Fischer, U.1    Janicke, R.U.2    Schulze-Osthoff, K.3
  • 51
    • 53349169853 scopus 로고    scopus 로고
    • Mediavilla-Varela M, Leoh LS, Basu A, Ganapathy V, Casiano CA. LEDGFp75/DFS70, a stress response autoantigen with multiple functions and broad clinical relevance. In: Conrad K Chan, EKL, Fritzler MJ. Sack U, Shoenfeld Y, Wiik A (eds), From Etiopathogenesis to the Prediction of Autoimmune Diseases: Relevance of Autoantibodies. Autoantigens, Autoantibodies and Autoimmunity series. 5. Lengerich (Germany) PABS Science Publishers. 2007 p.146-65.
    • Mediavilla-Varela M, Leoh LS, Basu A, Ganapathy V, Casiano CA. LEDGFp75/DFS70, a stress response autoantigen with multiple functions and broad clinical relevance. In: Conrad K Chan, EKL, Fritzler MJ. Sack U, Shoenfeld Y, Wiik A (eds), From Etiopathogenesis to the Prediction of Autoimmune Diseases: Relevance of Autoantibodies. Autoantigens, Autoantibodies and Autoimmunity series. Vol. 5. Lengerich (Germany) PABS Science Publishers. 2007 p.146-65.
  • 52
    • 33847049891 scopus 로고    scopus 로고
    • The histone methyltransferase activity of WHISTLE is important for the induction of apoptosis and HDAC1-mediated transcriptional repression
    • Kim SM, Kee HJ, Choe N, et al. The histone methyltransferase activity of WHISTLE is important for the induction of apoptosis and HDAC1-mediated transcriptional repression. Exp Cell Res 2007;313:975-83.
    • (2007) Exp Cell Res , vol.313 , pp. 975-983
    • Kim, S.M.1    Kee, H.J.2    Choe, N.3
  • 53
    • 40249106009 scopus 로고    scopus 로고
    • Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro
    • Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne M. Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro. Nucleic Acids Res 2008;36:1237-46.
    • (2008) Nucleic Acids Res , vol.36 , pp. 1237-1246
    • Botbol, Y.1    Raghavendra, N.K.2    Rahman, S.3    Engelman, A.4    Lavigne, M.5
  • 54
    • 0043170836 scopus 로고    scopus 로고
    • Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
    • Charvet C, Alberti I, Luciano F, et al. Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. Oncogene 2003;22:4557-68.
    • (2003) Oncogene , vol.22 , pp. 4557-4568
    • Charvet, C.1    Alberti, I.2    Luciano, F.3
  • 55
    • 1542319711 scopus 로고    scopus 로고
    • The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells
    • Kim W, Kook S, Kim DJ, Teodorof C, Song WK. The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells. J Biol Chem 2004;279:8333-42.
    • (2004) J Biol Chem , vol.279 , pp. 8333-8342
    • Kim, W.1    Kook, S.2    Kim, D.J.3    Teodorof, C.4    Song, W.K.5
  • 56
    • 0034717270 scopus 로고    scopus 로고
    • Apoptosis-induced cleavage of β-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential
    • Steinhusen U, Badock V, Bauer A, et al. Apoptosis-induced cleavage of β-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem 2000;275:16345-53.
    • (2000) J Biol Chem , vol.275 , pp. 16345-16353
    • Steinhusen, U.1    Badock, V.2    Bauer, A.3
  • 58
    • 0034917865 scopus 로고    scopus 로고
    • Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus
    • Nishizawa Y, Usukura J, Singh DP, Chylack LT, Shinohara T. Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res 2001;305:107-14.
    • (2001) Cell Tissue Res , vol.305 , pp. 107-114
    • Nishizawa, Y.1    Usukura, J.2    Singh, D.P.3    Chylack, L.T.4    Shinohara, T.5
  • 59
    • 0037262487 scopus 로고    scopus 로고
    • Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells
    • Kang S, Song J, Kang H, Kim S, Lee Y, Park D. Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells. Eur J Endocrinol 2003;148:147-55.
    • (2003) Eur J Endocrinol , vol.148 , pp. 147-155
    • Kang, S.1    Song, J.2    Kang, H.3    Kim, S.4    Lee, Y.5    Park, D.6
  • 60
    • 33746927884 scopus 로고    scopus 로고
    • The connection between splicing and cancer
    • Srebrow A, Kornblihtt AR. The connection between splicing and cancer. J Cell Sci 2006;119:2635-41.
    • (2006) J Cell Sci , vol.119 , pp. 2635-2641
    • Srebrow, A.1    Kornblihtt, A.R.2
  • 61
    • 0345239828 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and regulation of programmed cell death
    • Wu JY, Tang H, Havlioglu N. Alternative pre-mRNA splicing and regulation of programmed cell death. Prog Mol Subcell Biol 2003;31:153-85.
    • (2003) Prog Mol Subcell Biol , vol.31 , pp. 153-185
    • Wu, J.Y.1    Tang, H.2    Havlioglu, N.3
  • 62
    • 15844386531 scopus 로고    scopus 로고
    • Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway
    • Ebihara K, Masuhiro Y, Kitamoto T, et al. Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway. Mol Cell Biol 1996;16:3393-400.
    • (1996) Mol Cell Biol , vol.16 , pp. 3393-3400
    • Ebihara, K.1    Masuhiro, Y.2    Kitamoto, T.3
  • 64
    • 0035019156 scopus 로고    scopus 로고
    • Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells
    • Wysocka J, Reilly PT, Herr W. Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells. Mol Cell Biol 2001;21:3820-9.
    • (2001) Mol Cell Biol , vol.21 , pp. 3820-3829
    • Wysocka, J.1    Reilly, P.T.2    Herr, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.