Synthesis and preliminary evaluation of [18F]-fluoro-(2S)-Exaprolol for imaging cerebral β-adrenergic receptors with PET

Neurochemistry International

Volumn 53, Issue 5, 2008, Pages 173-179

  Stephenson, Karin A ^a,b   van Oosten, Erik M ^a,b   Wilson, Alan A ^a,b   Meyer, Jeffrey H ^a,b   Houle, Sylvain ^a,b   Vasdev, Neil ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adrenergic receptors; Exaprolol; Fluorine 18; Positron emission tomography (PET)

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; FLUOROEXAPROLOL F 18; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PROPRANOLOL; RADIOPHARMACEUTICAL AGENT; SEROTONIN 1A RECEPTOR; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN REGION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; IN VITRO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOCHEMISTRY; RAT;

ANIMALS; BRAIN; FLUORINE RADIOISOTOPES; MALE; POSITRON-EMISSION TOMOGRAPHY; PROPANOLAMINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; STEREOISOMERISM; TISSUE DISTRIBUTION;

RATTUS;

EID: 52049116081     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.06.013     Document Type: Article

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