Modeling considerations for11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET

Journal of Nuclear Medicine

Volumn 49, Issue 4, 2008, Pages 587-596

  Milak, Matthew S ^a,b,d   Severance, Alin J ^a   Ogden, R Todd ^a,b,c   Prabhakaran, Jaya ^a   Kumar, J S Dileep ^a,b   Majo, Vattoly J ^a   Mann, J John ^a,b   Parsey, Ramin V ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Columbia University ^*  (United States)

^d NONE   (United States)

Author keywords

Bootstrap; Compartment; Kinetic modeling; Test retest reproducibility; Voxel

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; DRUG METABOLITE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; O METHYL 2 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4 METHYL 1,2,4 TRIAZINE 3,5 (2H,4H)DIONE C 11; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; TRACER; UNCLASSIFIED DRUG; 2 (4 (4 (2 METHOXYPHENYL)PIPERAZIN 1 YL)BUTYL) 4 METHYL 1,2,4 TRIAZINE 3,5 (2H,4H) DIONE; 2-(4-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)BUTYL)-4-METHYL-1,2,4-TRIAZINE-3,5-(2H,4H)-DIONE; CARBON; DIAGNOSTIC AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SEROTONIN AGONIST; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTERIAL BLOOD; ARTICLE; BINDING SITE; BLOOD SAMPLING; BOOTSTRAPPING; CONTROLLED STUDY; DISSOCIATION CONSTANT; EVALUATION; IN VIVO STUDY; KINETICS; MALE; MOLECULAR IMAGING; NONHUMAN; OUTCOME ASSESSMENT; PAPIO ANUBIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; TEST RETEST RELIABILITY; VARIANCE; ANIMAL; BIOLOGICAL MODEL; DRUG POTENTIATION; METABOLISM; PAPIO;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CARBON RADIOISOTOPES; MALE; MODELS, BIOLOGICAL; PAPIO; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; TRIAZINES;

EID: 42049095298     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.046540     Document Type: Article

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