The in vitro pharmacology of the β-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned β-adrenergic receptors and moderate affinity for the human 5-HT1A receptor

Psychopharmacology

Volumn 157, Issue 1, 2001, Pages 111-114

  Roth, B L ^a   Ernsberger, P ^a   Steinberg, S ^a   Rao, S ^a   Rauser, L ^a   Savage, J ^a   Hufeisen, S ^a   Berridge, M S ^a   Muzic, R F ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT1A; Positron emission tomography; Adrenergic

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; FLUOROCARAZOLOL; LIGAND; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN REGION; CENTRAL NERVOUS SYSTEM; COMPUTER SIMULATION; DRUG RECEPTOR BINDING; HIPPOCAMPUS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; CARBAZOLES; HUMANS; LIGANDS; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT PROTEINS; STEREOISOMERISM; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034888987     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100844     Document Type: Article

References (14)

1. Specific beta-adrenergic receptor binding of carazolol measured with PET
2. Validation of S-1′-[18F] fluorocarazolol for in vivo imaging and quantification of cerebral beta-adrenoceptors
3. Role of norepinephrine in mediating stress hormone regulation of long-term memory storage: A critical involvement of the amygdala
4. The effect of long-acting beta2-agonists on airway inflammation in asthmatic patients
5. Brain noradrenergic receptors in major depression and schizophrenia
6. Involvement of the amygdala in memory storage: Interaction with other brain systems
7. Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis
8. Serotonin receptors in the human brain-III. Autoradiographic mapping of serotonin-1 receptors
9. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
10. Adrenergic receptors in Alzheimer's disease brain: Selective increases in the cerebella of aggressive patients
11. Imaging beta-adrenoceptors in the human brain with (S)-1'-[18F] fluorocarazolol
12. Beta-adrenergic receptor signaling: An acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha over-expression and other genetically engineered animal models
13. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain
14. 18F labeling of fluorocarazolol, a high-affinity beta-adrenergic receptor antagonist