Facile radiosynthesis of fluorine-18 labeled β-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol

Journal of Medicinal Chemistry

Volumn 51, Issue 16, 2008, Pages 5093-5100

  Stephenson, Karin A ^a   Wilson, Alan A ^a   Meyer, Jeffrey H ^a   Houle, Sylvain ^a   Vasdev, Neil ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 FLUOROPROPAN 2 YLAMINO) 3 (M TOLYLOXY)PROPAN 2 OL TOLIPROLOL F 18; 3 [1 [(BENZYLOXY)PROPAN 2 YL] 2 OXOOXAZOLIDIN 5 YL]METHYL 4 METHYLBENZENESULFONATE; BENZENESULFONAMIDE DERIVATIVE; BISOPROLOL; FLUORODEOXYGLUCOSE F 18; RADIOPHARMACEUTICAL AGENT; TOLIPROLOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG UPTAKE; ENANTIOMER; EX VIVO STUDY; FLUORINATION; FRONTAL CORTEX; ISOTOPE LABELING; MALE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; RADIOCHEMISTRY; RADIOISOTOPE DECAY; RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BRAIN; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 50249138751     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800227h     Document Type: Article

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