Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation

Matrix Biology

Volumn 25, Issue 6, 2006, Pages 323-331

  De Croos, J N A ^a   Dhaliwal, S S ^a   Grynpas, M D ^a,b   Pilliar, R M ^a,b   Kandel, R A ^a,b  

^a Pediatric Oral and Maxillofacial Surgery   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Chondrocytes; Collagen; Gene expression; Matrix metalloproteinases; Mechanical stimulation; Proteoglycan

Indexed keywords

AGGRECAN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGEN TYPE 2; COLLAGENASE 3; GELATINASE A; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEOGLYCAN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; STROMELYSIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CARTILAGE CELL; CATABOLISM; CELL CULTURE; COMPRESSION; CONTROLLED STUDY; CULTURE MEDIUM; DNA MODIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; MECHANICAL STIMULATION; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; BIOMECHANICS; CARTILAGE; CATTLE; CHONDROCYTES; COLLAGEN; CULTURE MEDIA; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; PRESSURE; TIME FACTORS; TISSUE ENGINEERING;

EID: 33746836954     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2006.03.005     Document Type: Article

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