메뉴 건너뛰기




Volumn 32, Issue 1, 2008, Pages 142-150

JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis

Author keywords

AS601245; Bacterial meningitis; c Jun N terminal kinase; D JNKI 1; Dentate gyrus; Neuronal apoptosis

Indexed keywords

(1,3 BENZOTHIAZOL 2 YL)[2 [2 (3 PYRIDINYL)ETHYLAMINO] 4 PYRIMIDINYL]ACETONITRILE; D JNKI 1; JNK ACTIVATING KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PROTEIN C JUN; PROTEIN INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 51349158213     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.07.006     Document Type: Article
Times cited : (17)

References (45)
  • 1
    • 16244387637 scopus 로고    scopus 로고
    • Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus
    • Barry C.E., et al. Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus. J. Neurochem. 93 (2005) 221-231
    • (2005) J. Neurochem. , vol.93 , pp. 221-231
    • Barry, C.E.1
  • 2
    • 34250873816 scopus 로고    scopus 로고
    • Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase
    • Beckham J.D., et al. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J. Virol. 81 (2007) 6984-6992
    • (2007) J. Virol. , vol.81 , pp. 6984-6992
    • Beckham, J.D.1
  • 3
    • 4344573714 scopus 로고    scopus 로고
    • Adult neuron survival strategies-slamming on the brakes
    • Benn S.C., and Woolf C.J. Adult neuron survival strategies-slamming on the brakes. Nat. Rev. Neurosci. 5 (2004) 686-700
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 686-700
    • Benn, S.C.1    Woolf, C.J.2
  • 4
    • 0037899314 scopus 로고    scopus 로고
    • Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats
    • Bifrare Y.D., et al. Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats. Hippocampus 13 (2003) 481-488
    • (2003) Hippocampus , vol.13 , pp. 481-488
    • Bifrare, Y.D.1
  • 5
    • 11144321597 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis
    • Bifrare Y.D., et al. Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis. J. Infect. Dis. 191 (2005) 40-45
    • (2005) J. Infect. Dis. , vol.191 , pp. 40-45
    • Bifrare, Y.D.1
  • 6
    • 0141724805 scopus 로고    scopus 로고
    • A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
    • Borsello T., et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9 (2003) 1180-1186
    • (2003) Nat. Med. , vol.9 , pp. 1180-1186
    • Borsello, T.1
  • 7
    • 0032977353 scopus 로고    scopus 로고
    • Neuroprotection by a caspase inhibitor in acute bacterial meningitis
    • Braun J.S., et al. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat. Med. 5 (1999) 298-302
    • (1999) Nat. Med. , vol.5 , pp. 298-302
    • Braun, J.S.1
  • 8
    • 13444301318 scopus 로고    scopus 로고
    • Specific pathophysiological functions of JNK isoforms in the brain
    • Brecht S., et al. Specific pathophysiological functions of JNK isoforms in the brain. Eur. J. Neurosci. 21 (2005) 363-377
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 363-377
    • Brecht, S.1
  • 9
    • 4143083990 scopus 로고    scopus 로고
    • Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death
    • Cao J., et al. Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J. Biol. Chem. 279 (2004) 35903-35913
    • (2004) J. Biol. Chem. , vol.279 , pp. 35903-35913
    • Cao, J.1
  • 10
    • 3042694681 scopus 로고    scopus 로고
    • AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties
    • Carboni S., et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J. Pharmacol. Exp. Ther. 310 (2004) 25-32
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 25-32
    • Carboni, S.1
  • 11
    • 14844333103 scopus 로고    scopus 로고
    • Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia
    • Carboni S., et al. Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia. J. Neurochem. 92 (2005) 1054-1060
    • (2005) J. Neurochem. , vol.92 , pp. 1054-1060
    • Carboni, S.1
  • 12
    • 0346037264 scopus 로고    scopus 로고
    • JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
    • Chang L., et al. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell. 4 (2003) 521-533
    • (2003) Dev. Cell. , vol.4 , pp. 521-533
    • Chang, L.1
  • 13
    • 0035884727 scopus 로고    scopus 로고
    • Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment
    • Christen S., et al. Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment. Free. Radic. Biol. Med. 31 (2001) 754-762
    • (2001) Free. Radic. Biol. Med. , vol.31 , pp. 754-762
    • Christen, S.1
  • 14
    • 34247133438 scopus 로고    scopus 로고
    • Error bars in experimental biology
    • Cumming G., et al. Error bars in experimental biology. J. Cell. Biol. 177 (2007) 7-11
    • (2007) J. Cell. Biol. , vol.177 , pp. 7-11
    • Cumming, G.1
  • 15
    • 0035089268 scopus 로고    scopus 로고
    • Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death
    • Eilers A., et al. Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death. J. Neurochem. 76 (2001) 1439-1454
    • (2001) J. Neurochem. , vol.76 , pp. 1439-1454
    • Eilers, A.1
  • 16
    • 38449096443 scopus 로고    scopus 로고
    • c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons
    • Eminel S., et al. c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons. J. Neurochem. 104 (2008) 957-969
    • (2008) J. Neurochem. , vol.104 , pp. 957-969
    • Eminel, S.1
  • 17
    • 22244479745 scopus 로고    scopus 로고
    • Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase
    • Gaillard P., et al. Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J. Med. Chem. 48 (2005) 4596-4607
    • (2005) J. Med. Chem. , vol.48 , pp. 4596-4607
    • Gaillard, P.1
  • 18
    • 0041620580 scopus 로고    scopus 로고
    • Increased neurogenesis after experimental Streptococcus pneumoniae meningitis
    • Gerber J., et al. Increased neurogenesis after experimental Streptococcus pneumoniae meningitis. J. Neurosci. Res. 73 (2003) 441-446
    • (2003) J. Neurosci. Res. , vol.73 , pp. 441-446
    • Gerber, J.1
  • 19
    • 0038388989 scopus 로고    scopus 로고
    • Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis
    • Gianinazzi C., et al. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol. (Berl). 105 (2003) 499-507
    • (2003) Acta Neuropathol. (Berl). , vol.105 , pp. 499-507
    • Gianinazzi, C.1
  • 20
    • 0033152450 scopus 로고    scopus 로고
    • Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
    • Gleeson J.G., et al. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23 (1999) 257-271
    • (1999) Neuron , vol.23 , pp. 257-271
    • Gleeson, J.G.1
  • 21
    • 33845592316 scopus 로고    scopus 로고
    • Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats
    • Grandgirard D., et al. Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats. Dev. Neurosci. 29 (2007) 134-142
    • (2007) Dev. Neurosci. , vol.29 , pp. 134-142
    • Grandgirard, D.1
  • 22
    • 0029076439 scopus 로고
    • Adverse outcomes of bacterial meningitis in school-age survivors
    • Grimwood K., et al. Adverse outcomes of bacterial meningitis in school-age survivors. Pediatrics 95 (1995) 646-656
    • (1995) Pediatrics , vol.95 , pp. 646-656
    • Grimwood, K.1
  • 23
    • 0035836656 scopus 로고    scopus 로고
    • Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
    • Jin K., et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 4710-4715
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4710-4715
    • Jin, K.1
  • 24
    • 0021742157 scopus 로고
    • Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models
    • Krawisz J.E., et al. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87 (1984) 1344-1350
    • (1984) Gastroenterology , vol.87 , pp. 1344-1350
    • Krawisz, J.E.1
  • 25
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan C.Y., et al. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22 (1999) 667-676
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1
  • 26
    • 10744229507 scopus 로고    scopus 로고
    • A critical role of neural-specific JNK3 for ischemic apoptosis
    • Kuan C.Y., et al. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15184-15189
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15184-15189
    • Kuan, C.Y.1
  • 27
    • 0034845846 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis
    • Leib S.L., et al. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124 (2001) 1734-1742
    • (2001) Brain , vol.124 , pp. 1734-1742
    • Leib, S.L.1
  • 28
    • 0035863578 scopus 로고    scopus 로고
    • The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis
    • Loeffler J.M., et al. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. J. Infect. Dis. 183 (2001) 247-252
    • (2001) J. Infect. Dis. , vol.183 , pp. 247-252
    • Loeffler, J.M.1
  • 29
    • 0038004740 scopus 로고    scopus 로고
    • Targeting JNK for therapeutic benefit: from junk to gold?
    • Manning A.M., and Davis R.J. Targeting JNK for therapeutic benefit: from junk to gold?. Nat Rev. Drug Discov. 2 (2003) 554-565
    • (2003) Nat Rev. Drug Discov. , vol.2 , pp. 554-565
    • Manning, A.M.1    Davis, R.J.2
  • 30
    • 0033929477 scopus 로고    scopus 로고
    • Cognitive outcome after bacterial meningitis
    • Merkelbach S., et al. Cognitive outcome after bacterial meningitis. Acta Neurol. Scand. 102 (2000) 118-123
    • (2000) Acta Neurol. Scand. , vol.102 , pp. 118-123
    • Merkelbach, S.1
  • 31
    • 9444269315 scopus 로고    scopus 로고
    • Dual phases of apoptosis in pneumococcal meningitis
    • Mitchell L., et al. Dual phases of apoptosis in pneumococcal meningitis. J. Infect. Dis. 190 (2004) 2039-2046
    • (2004) J. Infect. Dis. , vol.190 , pp. 2039-2046
    • Mitchell, L.1
  • 32
    • 0033030429 scopus 로고    scopus 로고
    • Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis
    • Nau R., et al. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J. Neuropathol. Exp. Neurol. 58 (1999) 265-274
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 265-274
    • Nau, R.1
  • 33
    • 4544255383 scopus 로고    scopus 로고
    • The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia
    • Okuno S., et al. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J. Neurosci. 24 (2004) 7879-7887
    • (2004) J. Neurosci. , vol.24 , pp. 7879-7887
    • Okuno, S.1
  • 34
    • 9444245015 scopus 로고    scopus 로고
    • Linking JNK signaling to NF-kappaB: a key to survival
    • Papa S., et al. Linking JNK signaling to NF-kappaB: a key to survival. J. Cell. Sci. 117 (2004) 5197-5208
    • (2004) J. Cell. Sci. , vol.117 , pp. 5197-5208
    • Papa, S.1
  • 35
    • 0034009119 scopus 로고    scopus 로고
    • Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis
    • Pfister L.A., et al. Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann. Neurol. 47 (2000) 329-335
    • (2000) Ann. Neurol. , vol.47 , pp. 329-335
    • Pfister, L.A.1
  • 36
    • 33845730329 scopus 로고    scopus 로고
    • Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage
    • Ren H., et al. Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage. J. Neurochem. 100 (2007) 532-544
    • (2007) J. Neurochem. , vol.100 , pp. 532-544
    • Ren, H.1
  • 37
    • 0036290266 scopus 로고    scopus 로고
    • Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis
    • Schaper M., et al. Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. J. Neuropathol. Exp. Neurol. 61 (2002) 605-613
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 605-613
    • Schaper, M.1
  • 38
    • 0030779037 scopus 로고    scopus 로고
    • Bacterial meningitis in the United States in 1995. Active Surveillance Team
    • Schuchat A., et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N. Engl. J. Med. 337 (1997) 970-976
    • (1997) N. Engl. J. Med. , vol.337 , pp. 970-976
    • Schuchat, A.1
  • 39
    • 33749049130 scopus 로고    scopus 로고
    • Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen-and stress-activated protein kinase
    • Sury M.D., et al. Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen-and stress-activated protein kinase. Free. Radic. Biol. Med. 41 (2006) 1372-1383
    • (2006) Free. Radic. Biol. Med. , vol.41 , pp. 1372-1383
    • Sury, M.D.1
  • 40
    • 23944466208 scopus 로고    scopus 로고
    • Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage
    • Waetzig V., and Herdegen T. Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage. Trends. Pharmacol. Sci. 26 (2005) 455-461
    • (2005) Trends. Pharmacol. Sci. , vol.26 , pp. 455-461
    • Waetzig, V.1    Herdegen, T.2
  • 41
    • 0030827809 scopus 로고    scopus 로고
    • Sequential expression and role of Hu RNA-binding proteins during neurogenesis
    • Wakamatsu Y., and Weston J.A. Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development 124 (1997) 3449-3460
    • (1997) Development , vol.124 , pp. 3449-3460
    • Wakamatsu, Y.1    Weston, J.A.2
  • 42
  • 43
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1
  • 44
    • 0030780804 scopus 로고    scopus 로고
    • Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • Yang D.D., et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 (1997) 865-870
    • (1997) Nature , vol.389 , pp. 865-870
    • Yang, D.D.1
  • 45
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang Z.Y., et al. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 26 (2006) 3551-3560
    • (2006) J. Neurosci. , vol.26 , pp. 3551-3560
    • Zhuang, Z.Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.