Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 7, 2002, Pages 605-613

  Schaper, Manuela ^a   Gergely, Suzanne ^a   Lykkesfeldt, Jens ^a   Zbären, Jakob ^a   Leib, Stephen L ^a   Täuber, Martin G ^a   Christen, Stephan ^a  

^a Institute for Infectious Diseases   (Switzerland)

Author keywords

Brain injury; Cerebral arteries; Lipid peroxidation; Reactive oxygen species; Vascular smooth muscle cells

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ANTIOXIDANT; CARBONYL DERIVATIVE; GLUTAMATE AMMONIA LIGASE; MANGANESE SUPEROXIDE DISMUTASE; N TERT BUTYL ALPHA PHENYLNITRONE; PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL MENINGITIS; BRAIN CIRCULATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOCHEMISTRY; LIPID PEROXIDATION; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0036290266     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.7.605     Document Type: Article

References (43)

1. Outcomes of bacterial meningitis in children: A meta-analysis
2. Adverse outcomes of bacterial meningitis in school-age survivors
3. Meningitis in infancy in England and Wales: Follow up at age 5 years
4. Pathogenesis of bacterial meningitis
5. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
6. Effects of clinically used antioxidants in experimental pneumococcal meningitis
7. Oxidative stress in brain during experimental bacterial meningitis: Differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment
8. Uptake and distribution of N-acetylcysteine in mice: Tissue-specific effects on glutathione concentrations
9. Multiple role of reactive oxygen species in the arterial wall
10. Oxidative stress in brain ischemia
11. Reactive oxygen-mediated protein oxidation in aging and disease
12. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/ reperfusion-induced injury to gerbil brain
13. Oxidative damage in Alzheimer's
14. 3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: Insights into Huntington's disease
15. Oxidative damage induced by the injection of HIV-1 Tat protein in the rat striatum
16. Widespread peroxynitrite-mediated damage in Alzheimer's disease
17. Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis
18. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis
19. Determination of carbonyl content in oxidatively modified proteins
20. Protein carbonyl measurement by a sensitive ELISA method
21. Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine
22. Determination of malondialdehyde as dithiobarbituric acid adduct in biological samples by HPLC with fluorescence detection: Comparison with ultraviolet-visible spectrophotometry
23. Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies
24. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine
25. Determination of protein carbonyl groups by immunoblotting
26. Labeling of proteins by reductive methylation using sodium cyanoborohydride
27. Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain
28. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci
29. Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis
30. Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats
31. Oxygen free radicals and the cerebral arteriolar response to group B streptococci
32. Nitric oxide insufficiency, platelet activation, and arterial thrombosis
33. Cerebral vasospasm and lipid peroxidation-Lipid peroxides in the cerebrospinal fluid after subarachnoid hemorrhage
34. Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a)
35. Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins
36. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium
37. Oxidative stress increases synthesis of big endothelin-1 by activation of the endothelin-1 promoter
38. Brain injury in experimental neonatal meningitis due to group B streptococci
39. Loss of cerebrovascular autoregulation in experimental meningitis in rabbits
40. Cerebral arteritis and phlebitis in pneumococcal meningitis
41. Abnormalities of cerebral blood flow in the acute phase of bacterial meningitis in adults
42. Cerebrovascular complications of bacterial meningitis in adults
43. Oxidative stress in bacterial meningitis in humans