메뉴 건너뛰기




Volumn 28, Issue 18, 2008, Pages 5555-5568

A unique protection signal in cubitus interruptus prevents its complete proteasomal degradation

Author keywords

[No Author keywords available]

Indexed keywords

CUBITUS INTERRUPTUS PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 51349156246     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00524-08     Document Type: Article
Times cited : (21)

References (51)
  • 1
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc, P., F. A. Ramirez-Weber, M. P. Laget, C. Schwartz, and T. B. Kornberg. 1997. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89: 1043-1053.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3    Schwartz, C.4    Kornberg, T.B.5
  • 2
    • 0024279384 scopus 로고
    • Ubiquitin-metallothionein fusion protein expression in yeast. A genetic approach for analysis of ubiquitin functions
    • Butt, T. R., M. I. Khan, J. Marsh, D. J. Ecker, and S. T. Crooke. 1988. Ubiquitin-metallothionein fusion protein expression in yeast. A genetic approach for analysis of ubiquitin functions. J. Biol. Chem. 263:16364-16371.
    • (1988) J. Biol. Chem , vol.263 , pp. 16364-16371
    • Butt, T.R.1    Khan, M.I.2    Marsh, J.3    Ecker, D.J.4    Crooke, S.T.5
  • 3
    • 0033529667 scopus 로고    scopus 로고
    • Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
    • Chen, C. H., D. P. von Kessler, W. Park, B. Wang, Y. Ma, and P. A. Beachy. 1999. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98:305-316.
    • (1999) Cell , vol.98 , pp. 305-316
    • Chen, C.H.1    von Kessler, D.P.2    Park, W.3    Wang, B.4    Ma, Y.5    Beachy, P.A.6
  • 4
    • 0032478107 scopus 로고    scopus 로고
    • Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
    • Chen, Y., N. Gallaher, R. H. Goodman, and S. M. Smolik. 1998. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95:2349-2354.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2349-2354
    • Chen, Y.1    Gallaher, N.2    Goodman, R.H.3    Smolik, S.M.4
  • 5
    • 0038617829 scopus 로고    scopus 로고
    • A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci
    • Dai, P., H. Akimaru, and S. Ishii. 2003. A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell 4:917-928.
    • (2003) Dev. Cell , vol.4 , pp. 917-928
    • Dai, P.1    Akimaru, H.2    Ishii, S.3
  • 7
    • 0035871301 scopus 로고    scopus 로고
    • Recruitment of the transcriptional machinery through GAL11P: Structure and interactions of the GAL4 dimerization domain
    • Hidalgo, P., A. Z. Ansari, P. Schmidt, B. Hare, N. Simkovich, S. Farrell, E. J. Shin, M. Ptashne, and G. Wagner. 2001. Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain. Genes Dev. 15:1007-1020.
    • (2001) Genes Dev , vol.15 , pp. 1007-1020
    • Hidalgo, P.1    Ansari, A.Z.2    Schmidt, P.3    Hare, B.4    Simkovich, N.5    Farrell, S.6    Shin, E.J.7    Ptashne, M.8    Wagner, G.9
  • 8
    • 0034268493 scopus 로고    scopus 로고
    • Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
    • Hoppe, T., K. Matuschewski, M. Rape, S. Schlenker, H. D. Ulrich, and S. Jentsch. 2000. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102:577-586.
    • (2000) Cell , vol.102 , pp. 577-586
    • Hoppe, T.1    Matuschewski, K.2    Rape, M.3    Schlenker, S.4    Ulrich, H.D.5    Jentsch, S.6
  • 9
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham, P. W., and A. P. McMahon. 2001. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 10
    • 28444449828 scopus 로고    scopus 로고
    • Phosphorylation by double-time/CKIε and CKIα targets cubitus interruptus for Slimb/β-TRCP-mediated proteolytic processing
    • Jia, J., L. Zhang, Q. Zhang, C. Tong, B. Wang, F. Hou, K. Amanai, and J. Jiang. 2005. Phosphorylation by double-time/CKIε and CKIα targets cubitus interruptus for Slimb/β-TRCP-mediated proteolytic processing. Dev. Cell 9:819-830.
    • (2005) Dev. Cell , vol.9 , pp. 819-830
    • Jia, J.1    Zhang, L.2    Zhang, Q.3    Tong, C.4    Wang, B.5    Hou, F.6    Amanai, K.7    Jiang, J.8
  • 11
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang, J., and G. Struhl. 1998. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 13
    • 33646875414 scopus 로고    scopus 로고
    • Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    • Kent, D., E. W. Bush, and J. E. Hooper. 2006. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133: 2001-2010.
    • (2006) Development , vol.133 , pp. 2001-2010
    • Kent, D.1    Bush, E.W.2    Hooper, J.E.3
  • 15
    • 0032549815 scopus 로고    scopus 로고
    • Cotranslational biogenesis of NF-κB p50 by the 26S proteasome
    • Lin, L., G. N. DeMartino, and W. C. Greene. 1998. Cotranslational biogenesis of NF-κB p50 by the 26S proteasome. Cell 92:819-828.
    • (1998) Cell , vol.92 , pp. 819-828
    • Lin, L.1    DeMartino, G.N.2    Greene, W.C.3
  • 16
    • 0034283010 scopus 로고    scopus 로고
    • Cotranslational dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production
    • Lin, L., G. N. DeMartino, and W. C. Greene. 2000. Cotranslational dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production. EMBO J. 19:4712-4722.
    • (2000) EMBO J , vol.19 , pp. 4712-4722
    • Lin, L.1    DeMartino, G.N.2    Greene, W.C.3
  • 17
    • 0029924035 scopus 로고    scopus 로고
    • A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit
    • Lin, L., and S. Ghosh. 1996. A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit. Mol. Cell. Biol. 16:2248-2254.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 2248-2254
    • Lin, L.1    Ghosh, S.2
  • 18
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • Lum, L., S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, M. Nirenberg, and P. A. Beachy. 2003. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299:2039-2045.
    • (2003) Science , vol.299 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    Von Kessler, D.5    Nirenberg, M.6    Beachy, P.A.7
  • 19
    • 0033582908 scopus 로고    scopus 로고
    • Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
    • Methot, N., and K. Basler. 1999. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96:819-831.
    • (1999) Cell , vol.96 , pp. 819-831
    • Methot, N.1    Basler, K.2
  • 20
    • 23844552405 scopus 로고    scopus 로고
    • Cooperative requirement of the Gli proteins in neurogenesis
    • Nguyen, V., A. L. Chokas, B. Stecca, and A. R. Altaba. 2005. Cooperative requirement of the Gli proteins in neurogenesis. Development 132:3267-3279.
    • (2005) Development , vol.132 , pp. 3267-3279
    • Nguyen, V.1    Chokas, A.L.2    Stecca, B.3    Altaba, A.R.4
  • 21
    • 0036083677 scopus 로고    scopus 로고
    • Drosophila Roc1a encodes a R1NG-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase
    • Noureddine, M. A., T. D. Donaldson, S. A. Thacker, and R. J. Duronio. 2002. Drosophila Roc1a encodes a R1NG-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev. Cell 2:757-770.
    • (2002) Dev. Cell , vol.2 , pp. 757-770
    • Noureddine, M.A.1    Donaldson, T.D.2    Thacker, S.A.3    Duronio, R.J.4
  • 22
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • Ohlmeyer, J. T., and D. Kalderon. 1998. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396:749-753.
    • (1998) Nature , vol.396 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 23
    • 0032954038 scopus 로고    scopus 로고
    • Structural motifs involved in ubiquitin-mediated processing of the NF-κB precursor p105: Roles of the glycine-rich region and a downstream ubiquitination domain
    • Orian, A., A. L. Schwartz, A. Israel, S. Whiteside, C. Kahana, and A. Ciechanover. 1999. Structural motifs involved in ubiquitin-mediated processing of the NF-κB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain. Mol. Cell. Biol. 19:3664-3673.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 3664-3673
    • Orian, A.1    Schwartz, A.L.2    Israel, A.3    Whiteside, S.4    Kahana, C.5    Ciechanover, A.6
  • 24
    • 0029847806 scopus 로고    scopus 로고
    • Crystal structure of the Aequorea victoria green fluorescent protein
    • Ormo, M., A. B. Cubitt, K. Kallio, L. A. Gross, R. Y. Tsien, and S. J. Remington. 1996. Crystal structure of the Aequorea victoria green fluorescent protein. Science 273:1392-1395.
    • (1996) Science , vol.273 , pp. 1392-1395
    • Ormo, M.1    Cubitt, A.B.2    Kallio, K.3    Gross, L.A.4    Tsien, R.Y.5    Remington, S.J.6
  • 25
    • 0037106185 scopus 로고    scopus 로고
    • Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development
    • Ou, C. Y., Y. F. Lin, Y. J. Chen, and C. T. Chien. 2002. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16:2403-2414.
    • (2002) Genes Dev , vol.16 , pp. 2403-2414
    • Ou, C.Y.1    Lin, Y.F.2    Chen, Y.J.3    Chien, C.T.4
  • 26
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κ
    • Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κ. Cell 78:773-785.
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 27
    • 33646270662 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    • Pan, Y., C. B. Bai, A. L. Joyner, and B. Wang. 2006. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26:3365-3377.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 3365-3377
    • Pan, Y.1    Bai, C.B.2    Joyner, A.L.3    Wang, B.4
  • 28
    • 34249717798 scopus 로고    scopus 로고
    • A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
    • Pan, Y., and B. Wang. 2007. A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem. 282:10846-10852.
    • (2007) J. Biol. Chem , vol.282 , pp. 10846-10852
    • Pan, Y.1    Wang, B.2
  • 30
    • 0032756914 scopus 로고    scopus 로고
    • Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
    • Price, M. A., and D. Kalderon. 1999. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 126: 4331-4339.
    • (1999) Development , vol.126 , pp. 4331-4339
    • Price, M.A.1    Kalderon, D.2
  • 31
    • 0037155737 scopus 로고    scopus 로고
    • Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1
    • Price, M. A., and D. Kalderon. 2002. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell 108:823-835.
    • (2002) Cell , vol.108 , pp. 823-835
    • Price, M.A.1    Kalderon, D.2
  • 32
    • 0035977095 scopus 로고    scopus 로고
    • Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone
    • Rape, M., T. Hoppe, I. Gorr, M. Kalocay, H. Richly, and S. Jentsch. 2001. Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107:667-677.
    • (2001) Cell , vol.107 , pp. 667-677
    • Rape, M.1    Hoppe, T.2    Gorr, I.3    Kalocay, M.4    Richly, H.5    Jentsch, S.6
  • 33
    • 33748296367 scopus 로고    scopus 로고
    • Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics
    • Robert, B., and Y. Lallemand. 2006. Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics. Dev. Dyn. 235:2337-2352.
    • (2006) Dev. Dyn , vol.235 , pp. 2337-2352
    • Robert, B.1    Lallemand, Y.2
  • 34
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin, L. L., and F. J. de Sauvage. 2006. Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov. 5:1026-1033.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 35
    • 0027441807 scopus 로고
    • Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability
    • Serrano, L., A. G. Day, and A. R. Fersht. 1993. Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability. J. Mol. Biol. 233:305-312.
    • (1993) J. Mol. Biol , vol.233 , pp. 305-312
    • Serrano, L.1    Day, A.G.2    Fersht, A.R.3
  • 36
    • 41149180853 scopus 로고    scopus 로고
    • An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates
    • Shimeld, S. M., M. van den Heuvel, R. Dawber, and J. Briscoe. 2007. An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates. PLoS ONE 2:c864.
    • (2007) PLoS ONE , vol.2 , Issue.C864
    • Shimeld, S.M.1    van den Heuvel, M.2    Dawber, R.3    Briscoe, J.4
  • 37
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
    • Sisson, J. C., K. S. Ho, K. Suyama, and M. P. Scott. 1997. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90:235-245.
    • (1997) Cell , vol.90 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 38
    • 30044442183 scopus 로고    scopus 로고
    • Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
    • Smelkinson, M. G., and D. Kalderon. 2006. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr. Biol. 16:110-116.
    • (2006) Curr. Biol , vol.16 , pp. 110-116
    • Smelkinson, M.G.1    Kalderon, D.2
  • 39
    • 34848892735 scopus 로고    scopus 로고
    • Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
    • Smelkinson, M. G., Q. Zhou, and D. Kalderon. 2007. Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev. Cell 13:481-495.
    • (2007) Dev. Cell , vol.13 , pp. 481-495
    • Smelkinson, M.G.1    Zhou, Q.2    Kalderon, D.3
  • 40
    • 0033674452 scopus 로고    scopus 로고
    • A ubiquitin-based tagging system for controlled modulation of protein stability
    • Stack, J. H., M. Whitney, S. M. Rodems, and B. A. Pollok. 2000. A ubiquitin-based tagging system for controlled modulation of protein stability. Nat. Biotechnol. 18:1298-1302.
    • (2000) Nat. Biotechnol , vol.18 , pp. 1298-1302
    • Stack, J.H.1    Whitney, M.2    Rodems, S.M.3    Pollok, B.A.4
  • 42
    • 28544434064 scopus 로고    scopus 로고
    • A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB
    • Tian, L., R. A. Holmgren, and A. Matouschek. 2005. A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB. Nat. Struct. Mol. Biol. 12:1045-1053.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 1045-1053
    • Tian, L.1    Holmgren, R.A.2    Matouschek, A.3
  • 43
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang, B., J. F. Fallon, and P. A. Beachy. 2000. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100:423-434.
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 44
    • 30444437000 scopus 로고    scopus 로고
    • Evidence for the direct involvement of βTrCP in GH3 protein processing
    • Wang, B., and Y. Li. 2006. Evidence for the direct involvement of βTrCP in GH3 protein processing. Proc. Natl. Acad. Sci. USA 103:33-38.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 33-38
    • Wang, B.1    Li, Y.2
  • 45
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
    • Wang, G., K. Amanai, B. Wang, and J. Jiang. 2000. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev. 14:2893-2905.
    • (2000) Genes Dev , vol.14 , pp. 2893-2905
    • Wang, G.1    Amanai, K.2    Wang, B.3    Jiang, J.4
  • 46
    • 1942518275 scopus 로고    scopus 로고
    • Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
    • Wang, G., and J. Jiang. 2004. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Dev. Biol. 268:493-505.
    • (2004) Dev. Biol , vol.268 , pp. 493-505
    • Wang, G.1    Jiang, J.2
  • 47
    • 0029901640 scopus 로고    scopus 로고
    • Analysis of compositionally biased regions in sequence databases
    • Wootton, J. C., and S. Federhen. 1996. Analysis of compositionally biased regions in sequence databases. Methods Enzymol. 266:554-571.
    • (1996) Methods Enzymol , vol.266 , pp. 554-571
    • Wootton, J.C.1    Federhen, S.2
  • 48
    • 0035860090 scopus 로고    scopus 로고
    • RNA interference of gene expression (RNAi) in cultured Drosophila cells
    • Worby, C. A., N. Simonson-Leff, and J. E. Dixon. 2001. RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci. STKE 2001:PL1.
    • (2001) Sci. STKE , vol.2001
    • Worby, C.A.1    Simonson-Leff, N.2    Dixon, J.E.3
  • 49
    • 0037012847 scopus 로고    scopus 로고
    • Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    • Zacharias, D. A., J. D. Violin, A. C. Newton, and R. Y. Tsien. 2002. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-916.
    • (2002) Science , vol.296 , pp. 913-916
    • Zacharias, D.A.1    Violin, J.D.2    Newton, A.C.3    Tsien, R.Y.4
  • 50
    • 33646893705 scopus 로고    scopus 로고
    • A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    • Zhang, Q., L. Zhang, B. Wang, C. Y. Ou, C. T. Chien, and J. Jiang. 2006. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10:719-729.
    • (2006) Dev. Cell , vol.10 , pp. 719-729
    • Zhang, Q.1    Zhang, L.2    Wang, B.3    Ou, C.Y.4    Chien, C.T.5    Jiang, J.6
  • 51
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    • Zhang, W., Y. Zhao, C. Tong, G. Wang, B. Wang, J. Jia, and J. Jiang. 2005. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8:267-278.
    • (2005) Dev. Cell , vol.8 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5    Jia, J.6    Jiang, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.