-
1
-
-
0020326790
-
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
-
Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 1982; 257: 7847-51.
-
(1982)
J Biol Chem
, vol.257
, pp. 7847-7851
-
-
Castagna, M.1
Takai, Y.2
Kaibuchi, K.3
Sano, K.4
Kikkawa, U.5
Nishizuka, Y.6
-
2
-
-
0023764824
-
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
-
Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988; 334: 661-5.
-
(1988)
Nature
, vol.334
, pp. 661-665
-
-
Nishizuka, Y.1
-
3
-
-
1642421710
-
-
Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117: 131-2.
-
Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117: 131-2.
-
-
-
-
4
-
-
0029610692
-
Lipid mediators and protein kinase C for intra-cellular signalling
-
Nishizuka Y, Nakamura S. Lipid mediators and protein kinase C for intra-cellular signalling. Clin Exp Pharmacol Physiol Suppl 1995; 22: S202-S203.
-
(1995)
Clin Exp Pharmacol Physiol Suppl
, vol.22
-
-
Nishizuka, Y.1
Nakamura, S.2
-
5
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007; 7: 281-94.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
6
-
-
0033601367
-
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein
-
Wang QJ, Bhattacharyya D, Garfield S, Nacro K, Marquez VE, Blumberg PM. Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J Biol Chem 1999; 274: 37233-9.
-
(1999)
J Biol Chem
, vol.274
, pp. 37233-37239
-
-
Wang, Q.J.1
Bhattacharyya, D.2
Garfield, S.3
Nacro, K.4
Marquez, V.E.5
Blumberg, P.M.6
-
7
-
-
0029812896
-
Ubiquitination of protein kinase C-alpha and degradation by the proteasome
-
Lee HW, Smith L, Pettit GR, Vinitsky A, Smith JB. Ubiquitination of protein kinase C-alpha and degradation by the proteasome. J Biol Chem 1996; 271: 20973-6.
-
(1996)
J Biol Chem
, vol.271
, pp. 20973-20976
-
-
Lee, H.W.1
Smith, L.2
Pettit, G.R.3
Vinitsky, A.4
Smith, J.B.5
-
8
-
-
0031907117
-
Activation of protein kinase C triggers its ubiquitination and degradation
-
Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA. Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol 1998; 18: 839-45.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 839-845
-
-
Lu, Z.1
Liu, D.2
Hornia, A.3
Devonish, W.4
Pagano, M.5
Foster, D.A.6
-
9
-
-
1242339601
-
Identification of two distinct pathways of protein kinase C-alpha down-regulation in intestinal epithelial cells
-
Leontieva OV, Black JD. Identification of two distinct pathways of protein kinase C-alpha down-regulation in intestinal epithelial cells. J Biol Chem 2004; 279: 5788-801.
-
(2004)
J Biol Chem
, vol.279
, pp. 5788-5801
-
-
Leontieva, O.V.1
Black, J.D.2
-
10
-
-
0027435064
-
The potential of protein kinase C as a target for anticancer treatment
-
Basu A. The potential of protein kinase C as a target for anticancer treatment. Pharmacol Ther 1993; 59: 257-80.
-
(1993)
Pharmacol Ther
, vol.59
, pp. 257-280
-
-
Basu, A.1
-
11
-
-
0031202791
-
Protein kinase C and tumorigenic potential]
-
Baron-Delage S, Cherqui G. [Protein kinase C and tumorigenic potential]. Bull Cancer 1997; 84: 829-32.
-
(1997)
Bull Cancer
, vol.84
, pp. 829-832
-
-
Baron-Delage, S.1
Cherqui, G.2
-
12
-
-
0027431098
-
Invasive human pituitary tumors express a point-mutated protein kinase C-alpha
-
Alvaro V, Levy L, Dubray C, et al. Invasive human pituitary tumors express a point-mutated protein kinase C-alpha. J Clin Endocrinol Metab 1993; 77: 1125-9.
-
(1993)
J Clin Endocrinol Metab
, vol.77
, pp. 1125-1129
-
-
Alvaro, V.1
Levy, L.2
Dubray, C.3
-
13
-
-
0033551660
-
Involvement of protein kinase C-epsilon (PKC-epsilon) in thyroid cell death. A truncated chimeric PKC-epsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis
-
Knauf JA, Elisei R, Mochly-Rosen D, et al. Involvement of protein kinase C-epsilon (PKC-epsilon) in thyroid cell death. A truncated chimeric PKC-epsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. J Biol Chem 1999; 274: 23414-25.
-
(1999)
J Biol Chem
, vol.274
, pp. 23414-23425
-
-
Knauf, J.A.1
Elisei, R.2
Mochly-Rosen, D.3
-
14
-
-
19644364146
-
The PKC-alpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals
-
Zhu Y, Dong Q, Tan BJ, Lim WG, Zhou S, Duan W. The PKC-alpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. Cancer Res 2005; 65: 4520-4.
-
(2005)
Cancer Res
, vol.65
, pp. 4520-4524
-
-
Zhu, Y.1
Dong, Q.2
Tan, B.J.3
Lim, W.G.4
Zhou, S.5
Duan, W.6
-
15
-
-
4444275128
-
Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas
-
Varga A, Czifra G, Tallai B, et al. Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. Eur Urol 2004; 46: 462-5.
-
(2004)
Eur Urol
, vol.46
, pp. 462-465
-
-
Varga, A.1
Czifra, G.2
Tallai, B.3
-
16
-
-
25144466151
-
Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma
-
Hans CP, Weisenburger DD, Greiner TC, et al. Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma. Mod Pathol 2005; 18: 1377-84.
-
(2005)
Mod Pathol
, vol.18
, pp. 1377-1384
-
-
Hans, C.P.1
Weisenburger, D.D.2
Greiner, T.C.3
-
17
-
-
24944563309
-
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
-
Pan Q, Ban LW, Kleer CG, et al. Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 2005; 65: 8366-71.
-
(2005)
Cancer Res
, vol.65
, pp. 8366-8371
-
-
Pan, Q.1
Ban, L.W.2
Kleer, C.G.3
-
18
-
-
0028815491
-
Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms
-
Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. J Biol Chem 1995; 270: 78-86.
-
(1995)
J Biol Chem
, vol.270
, pp. 78-86
-
-
Borner, C.1
Ueffing, M.2
Jaken, S.3
Parker, P.J.4
Weinstein, I.B.5
-
19
-
-
0027418816
-
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
-
Mischak H, Goodnight JA, Kolch W, et al. Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 1993; 268: 6090-6.
-
(1993)
J Biol Chem
, vol.268
, pp. 6090-6096
-
-
Mischak, H.1
Goodnight, J.A.2
Kolch, W.3
-
20
-
-
5344265130
-
Protein kinase C-alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma
-
Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR. Protein kinase C-alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. Eur J Cancer 2004; 40: 2269-73.
-
(2004)
Eur J Cancer
, vol.40
, pp. 2269-2273
-
-
Ainsworth, P.D.1
Winstanley, J.H.2
Pearson, J.M.3
Bishop, H.M.4
Garrod, D.R.5
-
21
-
-
1242273836
-
Immunohistochemical analysis of advanced human breast carcinomas reveals down regulation of protein kinase C-alpha
-
Kerfoot C, Huang W, Rotenberg SA. Immunohistochemical analysis of advanced human breast carcinomas reveals down regulation of protein kinase C-alpha. J Histochem Cytochem 2004; 52: 419-22.
-
(2004)
J Histochem Cytochem
, vol.52
, pp. 419-422
-
-
Kerfoot, C.1
Huang, W.2
Rotenberg, S.A.3
-
22
-
-
0028883765
-
Altered expression of cyclins and c-fos in R6 cells that overproduce PKC-epsilon
-
Han EK, Cacace AM, Sgambato A, Weinstein IB. Altered expression of cyclins and c-fos in R6 cells that overproduce PKC-epsilon. Carcinogenesis 1995; 16: 2423-8.
-
(1995)
Carcinogenesis
, vol.16
, pp. 2423-2428
-
-
Han, E.K.1
Cacace, A.M.2
Sgambato, A.3
Weinstein, I.B.4
-
23
-
-
0029086492
-
Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells
-
Basu A, Weixel KM. Comparison of protein kinase C activity and isoform expression in cisplatin-sensitive and -resistant ovarian carcinoma cells. Int J Cancer 1995; 62: 457-60.
-
(1995)
Int J Cancer
, vol.62
, pp. 457-460
-
-
Basu, A.1
Weixel, K.M.2
-
24
-
-
0037144492
-
Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway
-
Ding L, Wang H, Lang W, Xiao L. Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. J Biol Chem 2002; 277: 35305-13.
-
(2002)
J Biol Chem
, vol.277
, pp. 35305-35313
-
-
Ding, L.1
Wang, H.2
Lang, W.3
Xiao, L.4
-
25
-
-
1842454982
-
The enigmatic protein kinase C-delta: Complex roles in cell proliferation and survival
-
Jackson DN, Foster DA. The enigmatic protein kinase C-delta: complex roles in cell proliferation and survival. FASEB J 2004; 18: 627-36
-
(2004)
FASEB J
, vol.18
, pp. 627-636
-
-
Jackson, D.N.1
Foster, D.A.2
-
26
-
-
23844521568
-
The protein kinase C-beta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff JR, McNulty AM, Hanna KR, et al. The protein kinase C-beta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005; 65: 7462-9.
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
-
27
-
-
29444437443
-
Enzastaurin and pemetrexed exert synergistic antitumor activity in thyroid cancer cell lines in vitro
-
Oberschmidt O, Eismann U, Schulz L, et al. Enzastaurin and pemetrexed exert synergistic antitumor activity in thyroid cancer cell lines in vitro. Int J Clin Pharmacol Ther 2005; 43: 603-4.
-
(2005)
Int J Clin Pharmacol Ther
, vol.43
, pp. 603-604
-
-
Oberschmidt, O.1
Eismann, U.2
Schulz, L.3
-
28
-
-
34248631942
-
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in vitro [corrected] soft-agar cloning experiments
-
Hanauske AR, Oberschmidt O, Hanauske-Abel H, Lahn MM, Eismann U. Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in vitro [corrected] soft-agar cloning experiments. Invest New Drugs 2007; 25: 205-10.
-
(2007)
Invest New Drugs
, vol.25
, pp. 205-210
-
-
Hanauske, A.R.1
Oberschmidt, O.2
Hanauske-Abel, H.3
Lahn, M.M.4
Eismann, U.5
-
29
-
-
33748670455
-
Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C-beta inhibitor, in patients with advanced cancer
-
Carducci MA, Musib L, Kies MS, et al. Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C-beta inhibitor, in patients with advanced cancer. J Clin Oncol 2006; 24: 4092-9.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4092-4099
-
-
Carducci, M.A.1
Musib, L.2
Kies, M.S.3
-
30
-
-
51349140650
-
Comparison of enzastaurin pharmacokinetics and safety in the once daily (QD) and twice daily (BID) dose regimens: A phase I study
-
Hanauske A, Musib L, Weigang-Kohler K, et al. Comparison of enzastaurin pharmacokinetics and safety in the once daily (QD) and twice daily (BID) dose regimens: A phase I study. ASCO Meeting Abstracts 2007; 25: 14021.
-
(2007)
ASCO Meeting Abstracts
, vol.25
, pp. 14021
-
-
Hanauske, A.1
Musib, L.2
Weigang-Kohler, K.3
-
31
-
-
34249075706
-
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma
-
Robertson MJ, Kahl BS, Vose JM, et al. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol 2007; 25: 1741-6.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1741-1746
-
-
Robertson, M.J.1
Kahl, B.S.2
Vose, J.M.3
-
32
-
-
38949178850
-
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma
-
Morschhauser F, Seymour JF, Kluin-Nelemans HC, et al. A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Ann Oncol 2007; 19: 247-53.
-
(2007)
Ann Oncol
, vol.19
, pp. 247-253
-
-
Morschhauser, F.1
Seymour, J.F.2
Kluin-Nelemans, H.C.3
-
33
-
-
33646555670
-
-
Results from phase II trial of enzastaurin LY317615, patients with recurrent high-grade gliomas, Meeting Abstracts
-
Fine HA, Kim L, Royce C, et al. Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high-grade gliomas. J Clin Oncol 2005; 23: 1504; (Meeting Abstracts).
-
(2005)
J Clin Oncol
, vol.23
, pp. 1504
-
-
Fine, H.A.1
Kim, L.2
Royce, C.3
-
34
-
-
34848870215
-
A phase II study of enzastaurin as second- or third-line treatment of non-small cell lung cancer (NSCLC)
-
Bepler G, Oh Y, Burris H, Cleverly A, Lahn M, Herbst RS. A phase II study of enzastaurin as second- or third-line treatment of non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 2007; 25: 7543.
-
(2007)
ASCO Meeting Abstracts
, vol.25
, pp. 7543
-
-
Bepler, G.1
Oh, Y.2
Burris, H.3
Cleverly, A.4
Lahn, M.5
Herbst, R.S.6
-
35
-
-
33846914141
-
Targeting PKC in multiple myeloma: In vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
-
Podar K, Raab MS, Zhang J, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood 2007; 109: 1669-77.
-
(2007)
Blood
, vol.109
, pp. 1669-1677
-
-
Podar, K.1
Raab, M.S.2
Zhang, J.3
-
36
-
-
34249746834
-
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia
-
Moreau AS, Jia X, Ngo HT, et al. Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia. Blood 2007; 109: 4964-72.
-
(2007)
Blood
, vol.109
, pp. 4964-4972
-
-
Moreau, A.S.1
Jia, X.2
Ngo, H.T.3
-
37
-
-
34548215654
-
Phase I and pharmacokinetic evaluation of enzastaurin combined with gemcitabine and cisplatin in advanced cancer
-
Beerepoot L, Rademaker-Lakhai J, Witteveen E, et al. Phase I and pharmacokinetic evaluation of enzastaurin combined with gemcitabine and cisplatin in advanced cancer. ASCO Meeting Abstracts 2006; 24: 2046.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 2046
-
-
Beerepoot, L.1
Rademaker-Lakhai, J.2
Witteveen, E.3
-
38
-
-
34848883049
-
Phase I/II study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM) or gliosarcoma
-
Butowski NA, Lamborn K, Chang S, et al. Phase I/II study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM) or gliosarcoma. ASCO Meeting Abstracts 2007; 25: 12511.
-
(2007)
ASCO Meeting Abstracts
, vol.25
, pp. 12511
-
-
Butowski, N.A.1
Lamborn, K.2
Chang, S.3
-
39
-
-
34250836160
-
A phase I dose-escalation and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced cancer
-
Leong S, Camidge R, Eckhardt G, et al. A phase I dose-escalation and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced cancer. ASCO Meeting Abstracts 2006; 24: 2048.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 2048
-
-
Leong, S.1
Camidge, R.2
Eckhardt, G.3
-
40
-
-
34250827591
-
Pharmacokinetic interaction and safety of enzastaurin and pemetrexed in patients with advanced or metastatic cancer
-
Hanauske A, Weigang Koehler K, Yilmaz E, et al. Pharmacokinetic interaction and safety of enzastaurin and pemetrexed in patients with advanced or metastatic cancer. ASCO Meeting Abstracts 2006; 24: 2047.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 2047
-
-
Hanauske, A.1
Weigang Koehler, K.2
Yilmaz, E.3
-
41
-
-
0031827507
-
Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer
-
discussion 223-4
-
Denham DW, Franz MG, Denham W, et al. Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer. Surgery 1998; 124: 218-23; (discussion 223-4).
-
(1998)
Surgery
, vol.124
, pp. 218-223
-
-
Denham, D.W.1
Franz, M.G.2
Denham, W.3
-
42
-
-
0032486223
-
Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha
-
Dennis JU, Dean NM, Bennett CF, Griffith JW, Lang CM, Welch DR. Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha. Cancer Lett 1998; 128: 65-70.
-
(1998)
Cancer Lett
, vol.128
, pp. 65-70
-
-
Dennis, J.U.1
Dean, N.M.2
Bennett, C.F.3
Griffith, J.W.4
Lang, C.M.5
Welch, D.R.6
-
43
-
-
0029833019
-
Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide
-
Yazaki T, Ahmad S, Chahlavi A, et al. Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. Mol Pharmacol 1996; 50: 236-42.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 236-242
-
-
Yazaki, T.1
Ahmad, S.2
Chahlavi, A.3
-
44
-
-
0033019842
-
Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multi-forme cells by a protein kinase C-alpha antisense oligonucleotide
-
Shen L, Dean NM, Glazer RI. Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multi-forme cells by a protein kinase C-alpha antisense oligonucleotide. Mol Pharmacol 1999; 55: 396-402.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 396-402
-
-
Shen, L.1
Dean, N.M.2
Glazer, R.I.3
-
45
-
-
0032730429
-
Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer
-
Nemunaitis J, Holmlund JT, Kraynak M, et al. Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer. J Clin Oncol 1999; 17: 3586-95.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3586-3595
-
-
Nemunaitis, J.1
Holmlund, J.T.2
Kraynak, M.3
-
46
-
-
0032730633
-
Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer
-
Yuen AR, Halsey J, Fisher GA, et al. Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer. Clin Cancer Res 1999; 5: 3357-63.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3357-3363
-
-
Yuen, A.R.1
Halsey, J.2
Fisher, G.A.3
-
47
-
-
23844504109
-
A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer
-
Advani R, Lum BL, Fisher GA, et al. A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer. Invest New Drugs 2005; 23: 467-77.
-
(2005)
Invest New Drugs
, vol.23
, pp. 467-477
-
-
Advani, R.1
Lum, B.L.2
Fisher, G.A.3
-
48
-
-
4644305430
-
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma
-
Rao S, Watkins D, Cunningham D, et al. Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma. Ann Oncol 2004; 15: 1413-8.
-
(2004)
Ann Oncol
, vol.15
, pp. 1413-1418
-
-
Rao, S.1
Watkins, D.2
Cunningham, D.3
-
49
-
-
0035992350
-
Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: A National Cancer Institute of Canada Clinical Trials Group Study
-
Cripps MC, Figueredo AT, Oza AM, et al. Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada Clinical Trials Group Study. Clin Cancer Res 2002; 8: 2188-92.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2188-2192
-
-
Cripps, M.C.1
Figueredo, A.T.2
Oza, A.M.3
-
50
-
-
19944422076
-
A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer
-
Marshall JL, Eisenberg SG, Johnson MD, et al. A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer. Clin Colorectal Cancer 2004; 4: 268-74.
-
(2004)
Clin Colorectal Cancer
, vol.4
, pp. 268-274
-
-
Marshall, J.L.1
Eisenberg, S.G.2
Johnson, M.D.3
-
51
-
-
14644438523
-
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas
-
Grossman SA, Alavi JB, Supko JG, et al. Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. Neuro-oncol 2005; 7: 32-40.
-
(2005)
Neuro-oncol
, vol.7
, pp. 32-40
-
-
Grossman, S.A.1
Alavi, J.B.2
Supko, J.G.3
-
52
-
-
9144226837
-
A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C-alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma
-
Advani R, Peethambaram P, Lum BL, et al. A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C-alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma. Cancer 2004; 100: 321-6.
-
(2004)
Cancer
, vol.100
, pp. 321-326
-
-
Advani, R.1
Peethambaram, P.2
Lum, B.L.3
-
53
-
-
0036023413
-
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer
-
Tolcher AW, Reyno L, Venner PM, et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res 2002; 8: 2530-5.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2530-2535
-
-
Tolcher, A.W.1
Reyno, L.2
Venner, P.M.3
-
54
-
-
0036554842
-
Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer
-
Mani S, Rudin CM, Kunkel K, et al. Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer. Clin Cancer Res 2002; 8: 1042-8.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1042-1048
-
-
Mani, S.1
Rudin, C.M.2
Kunkel, K.3
-
55
-
-
4644262519
-
A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
-
Villalona-Calero MA, Ritch P, Figueroa JA, et al. A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. Clin Cancer Res 2004; 10: 6086-93.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6086-6093
-
-
Villalona-Calero, M.A.1
Ritch, P.2
Figueroa, J.A.3
-
56
-
-
18844365940
-
Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer
-
Vansteenkiste J, Canon JL, Riska H, et al. Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer. Invest New Drugs 2005; 23: 263-9.
-
(2005)
Invest New Drugs
, vol.23
, pp. 263-269
-
-
Vansteenkiste, J.1
Canon, J.L.2
Riska, H.3
-
57
-
-
33645962526
-
Phase II study of PKC-alpha anti-sense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer
-
Ritch P, Rudin CM, Bitran JD, et al. Phase II study of PKC-alpha anti-sense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer. Lung Cancer 2006; 52: 173-80.
-
(2006)
Lung Cancer
, vol.52
, pp. 173-180
-
-
Ritch, P.1
Rudin, C.M.2
Bitran, J.D.3
-
58
-
-
0242455819
-
Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: Initial report
-
abstr 2504
-
Lynch TJ, Raju R, Lind M, et al. Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: initial report. Proc Am Soc Clin Oncol 2003; 22; [(abstr 2504) 2003].
-
(2003)
Proc Am Soc Clin Oncol
, vol.2003
, pp. 22
-
-
Lynch, T.J.1
Raju, R.2
Lind, M.3
-
59
-
-
33645453677
-
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer
-
Paz-Ares L, Douillard JY, Koralewski P, et al. Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2006; 24: 1428-34.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1428-1434
-
-
Paz-Ares, L.1
Douillard, J.Y.2
Koralewski, P.3
-
60
-
-
0032829936
-
Pkt 412]
-
Lansiaux A, Fabbro D, Meyer T, Hamy F, Bailly C. [Pkt 412]. Bull Cancer 1999; 86: 614-7.
-
(1999)
Bull Cancer
, vol.86
, pp. 614-617
-
-
Lansiaux, A.1
Fabbro, D.2
Meyer, T.3
Hamy, F.4
Bailly, C.5
-
61
-
-
18844478996
-
PKC412 - a protein kinase inhibitor with a broad therapeutic potential
-
Fabbro D, Ruetz S, Bodis S, et al. PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des 2000; 15: 17-28.
-
(2000)
Anticancer Drug Des
, vol.15
, pp. 17-28
-
-
Fabbro, D.1
Ruetz, S.2
Bodis, S.3
-
62
-
-
0035281737
-
Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
-
Propper DJ, McDonald AC, Man A, et al. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol 2001; 19: 1485-92.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1485-1492
-
-
Propper, D.J.1
McDonald, A.C.2
Man, A.3
-
63
-
-
10744221763
-
A phase I trial of daily oral 4′- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluoro-uracil in patients with advanced solid malignancies
-
Eder Jr. JP, Garcia-Carbonero R, Clark JW, et al. A phase I trial of daily oral 4′- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluoro-uracil in patients with advanced solid malignancies. Invest New Drugs 2004; 22: 139-50.
-
(2004)
Invest New Drugs
, vol.22
, pp. 139-150
-
-
Eder Jr., J.P.1
Garcia-Carbonero, R.2
Clark, J.W.3
-
64
-
-
1342310067
-
Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer
-
Monnerat C, Henriksson R, Le Chevalier T, et al. Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer. Ann Oncol 2004; 15: 316-23.
-
(2004)
Ann Oncol
, vol.15
, pp. 316-323
-
-
Monnerat, C.1
Henriksson, R.2
Le Chevalier, T.3
-
65
-
-
33751177110
-
The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: The induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases
-
Knapper S, Mills KI, Gilkes AF, Austin SJ, Walsh V, Burnett AK. The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases. Blood 2006; 108: 3494-503.
-
(2006)
Blood
, vol.108
, pp. 3494-3503
-
-
Knapper, S.1
Mills, K.I.2
Gilkes, A.F.3
Austin, S.J.4
Walsh, V.5
Burnett, A.K.6
-
66
-
-
30144432781
-
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain
-
Heidel F, Solem FK, Breitenbuecher F, et al. Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood 2006; 107: 293-300.
-
(2006)
Blood
, vol.107
, pp. 293-300
-
-
Heidel, F.1
Solem, F.K.2
Breitenbuecher, F.3
-
67
-
-
19944427559
-
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
-
Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 2005; 105: 54-60.
-
(2005)
Blood
, vol.105
, pp. 54-60
-
-
Stone, R.M.1
DeAngelo, D.J.2
Klimek, V.3
-
68
-
-
33845601781
-
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity
-
Weisberg E, Wright RD, Jiang J, et al. Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology 2006; 131: 1734-42.
-
(2006)
Gastroenterology
, vol.131
, pp. 1734-1742
-
-
Weisberg, E.1
Wright, R.D.2
Jiang, J.3
-
69
-
-
0024542411
-
-
Takahashi I, Saitoh Y, Yoshida M, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo) 1989; 42: 571-6.
-
Takahashi I, Saitoh Y, Yoshida M, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo) 1989; 42: 571-6.
-
-
-
-
70
-
-
0029871688
-
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line
-
Kawakami K, Futami H, Takahara J, Yamaguchi K. UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. Biochem Biophys Res Commun 1996; 219: 778-83.
-
(1996)
Biochem Biophys Res Commun
, vol.219
, pp. 778-783
-
-
Kawakami, K.1
Futami, H.2
Takahara, J.3
Yamaguchi, K.4
-
71
-
-
0030615323
-
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells
-
Akiyama T, Yoshida T, Tsujita T, et al. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res 1997; 57: 1495-501.
-
(1997)
Cancer Res
, vol.57
, pp. 1495-1501
-
-
Akiyama, T.1
Yoshida, T.2
Tsujita, T.3
-
72
-
-
0032145499
-
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein
-
Fuse E, Tanii H, Kurata N, et al. Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein. Cancer Res 1998; 58: 3248-53.
-
(1998)
Cancer Res
, vol.58
, pp. 3248-3253
-
-
Fuse, E.1
Tanii, H.2
Kurata, N.3
-
74
-
-
0035871444
-
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms
-
Sausville EA, Arbuck SG, Messmann R, et al. Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J Clin Oncol 2001; 19: 2319-33.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2319-2333
-
-
Sausville, E.A.1
Arbuck, S.G.2
Messmann, R.3
-
75
-
-
20144373035
-
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxy-staurosporine in combination with fluorouracil in patients with advanced solid tumors
-
Kortmansky J, Shah MA, Kaubisch A, et al. Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxy-staurosporine in combination with fluorouracil in patients with advanced solid tumors. J Clin Oncol 2005; 23: 1875-84.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1875-1884
-
-
Kortmansky, J.1
Shah, M.A.2
Kaubisch, A.3
-
76
-
-
0033868507
-
Chemistry and clinical biology of the bryostatins
-
Mutter R, Wills M. Chemistry and clinical biology of the bryostatins. Bioorg Med Chem 2000; 8: 1841-60.
-
(2000)
Bioorg Med Chem
, vol.8
, pp. 1841-1860
-
-
Mutter, R.1
Wills, M.2
-
77
-
-
33746912263
-
Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase C-delta
-
Choi SH, Hyman T, Blumberg PM. Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase C-delta. Cancer Res 2006; 66: 7261-9.
-
(2006)
Cancer Res
, vol.66
, pp. 7261-7269
-
-
Choi, S.H.1
Hyman, T.2
Blumberg, P.M.3
-
78
-
-
0000852678
-
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
-
Wender PA, Cribbs CM, Koehler KF, et al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci USA 1988; 85: 7197-201.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 7197-7201
-
-
Wender, P.A.1
Cribbs, C.M.2
Koehler, K.F.3
-
79
-
-
0029150243
-
Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2
-
Asiedu C, Biggs J, Lilly M, Kraft AS. Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2. Cancer Res 1995; 55: 3716-20.
-
(1995)
Cancer Res
, vol.55
, pp. 3716-3720
-
-
Asiedu, C.1
Biggs, J.2
Lilly, M.3
Kraft, A.S.4
-
80
-
-
0027326957
-
A phase I study of intravenous bryostatin 1 in patients with advanced cancer
-
Prendiville J, Crowther D, Thatcher N, et al. A phase I study of intravenous bryostatin 1 in patients with advanced cancer. Br J Cancer 1993; 68: 418-24.
-
(1993)
Br J Cancer
, vol.68
, pp. 418-424
-
-
Prendiville, J.1
Crowther, D.2
Thatcher, N.3
-
81
-
-
0027489606
-
Phase I study of bryostatin 1: Assessment of interleukin-6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee
-
Philip PA, Rea D, Thavasu P, et al. Phase I study of bryostatin 1: assessment of interleukin-6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee. J Natl Cancer Inst 1993; 85: 1812-8.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1812-1818
-
-
Philip, P.A.1
Rea, D.2
Thavasu, P.3
-
82
-
-
0029084804
-
A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24-hour intravenous infusion
-
Jayson GC, Crowther D, Prendiville J, et al. A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24-hour intravenous infusion. Br J Cancer 1995; 72: 461-8.
-
(1995)
Br J Cancer
, vol.72
, pp. 461-468
-
-
Jayson, G.C.1
Crowther, D.2
Prendiville, J.3
-
83
-
-
0031982782
-
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia
-
Varterasian ML, Mohammad RM, Eilender DS, et al. Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia. J Clin Oncol 1998; 16: 56-62.
-
(1998)
J Clin Oncol
, vol.16
, pp. 56-62
-
-
Varterasian, M.L.1
Mohammad, R.M.2
Eilender, D.S.3
-
84
-
-
0037283184
-
Perspectives on the oncologist pharmacopoeia]
-
Lansiaux A, Bailly C. [Perspectives on the oncologist pharmacopoeia]. Bull Cancer 2003; 90: 25-30.
-
(2003)
Bull Cancer
, vol.90
, pp. 25-30
-
-
Lansiaux, A.1
Bailly, C.2
-
85
-
-
0034887884
-
Cell cycle-mediated drug resistance: An emerging concept in cancer therapy
-
Shah MA, Schwartz GK. Cell cycle-mediated drug resistance: an emerging concept in cancer therapy. Clin Cancer Res 2001; 7: 2168-81.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2168-2181
-
-
Shah, M.A.1
Schwartz, G.K.2
-
86
-
-
0007863172
-
A Phase II Trial of Weekly One-Hour Paclitaxel Followed by Bryostatin-1 in Patients with Advanced Esophageal Cancer: An Active New Drug Combination
-
abstr 633
-
Ilson D, Shah M, O'Reilly E, et al. A Phase II Trial of Weekly One-Hour Paclitaxel Followed by Bryostatin-1 in Patients with Advanced Esophageal Cancer: an Active New Drug Combination. Proc Am Soc Clin Oncol 2001; 20: 159a (abstr 633).
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Ilson, D.1
Shah, M.2
O'Reilly, E.3
-
87
-
-
0003239584
-
Phase II Study of Bryostatin-1 in Combination with Paclitaxel for Advanced Non-Small Cell Lung Cancer (NSCLC)
-
abstr 2834
-
Charoentum C, Maeur AM, Gajewsky TF, et al. Phase II Study of Bryostatin-1 in Combination with Paclitaxel for Advanced Non-Small Cell Lung Cancer (NSCLC). Proc Am Soc Clin Oncol 2001; 20:271b (abstr 2834).
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Charoentum, C.1
Maeur, A.M.2
Gajewsky, T.F.3
-
88
-
-
51349085274
-
Enzastaurin safety review: Data from phase I and phase II trials
-
Watkins V, Hong S, Lin B. Enzastaurin safety review: Data from phase I and phase II trials. ASCO Meeting Abstracts 2006; 24: 13077.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 13077
-
-
Watkins, V.1
Hong, S.2
Lin, B.3
-
89
-
-
33745204140
-
Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor
-
Green LJ, Marder P, Ray C, et al. Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor. Clin Cancer Res 2006; 12: 3408-15.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3408-3415
-
-
Green, L.J.1
Marder, P.2
Ray, C.3
-
90
-
-
51349138158
-
In vitro chemosensitivity against enzastaurin correlates with gene expression of IL8 and GSK3-beta
-
Oberschmidt O, Eismann U, Lahn MM, et al. In vitro chemosensitivity against enzastaurin correlates with gene expression of IL8 and GSK3-beta. ASCO Meeting Abstracts 2006; 24: 13046.
-
(2006)
ASCO Meeting Abstracts
, vol.24
, pp. 13046
-
-
Oberschmidt, O.1
Eismann, U.2
Lahn, M.M.3
-
91
-
-
51349124197
-
Effects of PKC beta inhibitor enzastaurin on chemoresistant ovarian cancer cell lines
-
Meinhold-Heerlein I, Brautigam K, Bauerschlag D, et al. Effects of PKC beta inhibitor enzastaurin on chemoresistant ovarian cancer cell lines. ASCO Meeting Abstracts 2007; 25: 16030.
-
(2007)
ASCO Meeting Abstracts
, vol.25
, pp. 16030
-
-
Meinhold-Heerlein, I.1
Brautigam, K.2
Bauerschlag, D.3
|