Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cδ

Cancer Research

Volumn 66, Issue 14, 2006, Pages 7261-7269

  Choi, Sung Hee ^a   Hyman, Tehila ^a   Blumberg, Peter M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN 1; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA;

ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL FRACTIONATION; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARCINOMA, NON-SMALL-CELL LUNG; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MACROLIDES; PROTEIN KINASE C-DELTA; TETRADECANOYLPHORBOL ACETATE;

EID: 33746912263     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4177     Document Type: Article

References (56)

1. Dekker LV, Parker PJ. Protein kinase C-a question of specificity. Trends Biochem Sci 1994;19:73-7.
2. Toker A. Signaling through protein kinase C. Front Biosci 1998;3:D1134-47.
3. Parker PJ, Kour G, Marais RM, et al. Protein kinase C-a family affair. Mol Cell Endocrinol 1989;65:1-11.
4. Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Sci 1998;6:477-80.
5. Mischak H, Goodnight JA, Kolch W, et al. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 1993;268:6090-6.
6. Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphorylation of protein kinase Cδ is essential for its apoptotic effect in response to etoposide. Mol Cell Biol 2002;22:182-95.
7. Zrachia A, Dobroslav M, Blass M, et al. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase Cδ. Implications for Sindbis virus-induced apoptosis. J Biol Chem 2002;277:23693-701.
8. Okhrimenko H, Lu W, Xiang C, et al. Roles of tyrosine phosphorylation and cleavage of protein kinase Cδ in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J Biol Chem 2005;280:23643-52.
9. Blumberg PM. Complexities of the protein kinase C pathway. Mol Carcinog 1991;4:339-44.
10. Mochly-Rosen D, Gordon AS. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 1998;12:35-42.
11. Wang QJ, Bhattacharyya D, Garfield S, Nacro K, Marquez VE, Blumberg PM. Differential localization of protein kinase Cδ by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J Biol Chem 1999;274:37233-9.
12. Sakai N, Sasaki K, Ikegaki N, Shirai Y, Ono Y, Saito N. Direct visualization of the translocation of the γ-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J Cell Biol 1997;139:1465-76.
13. Harada K, Maekawa T, Abu Shama KM, Yamashima T, Yoshida K. Translocation and down-regulation of protein kinase C-α, -β, and -γ isoforms during ischemia-reperfusion in rat brain. J Neurochem 1999;72:2556-64.
14. Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA. Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol 1998;18:839-45.
15. Kishimoto A, Mikawa K, Hashimoto K, et al. Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J Biol Chem 1989;264:4088-92.
16. Jalava A, Lintunen M, Heikkila J. Protein kinase C-α but not protein kinase C-ε is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells. Biochem Biophys Res Commun 1993;191:472-8.
17. MacKenzie S, Fleming I, Houslay MD, Anderson NG, Kilgour E. Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-442A cells. Biochem J 1997;324:159-65.
18. Zonder JA, Shields AF, Zalupski M, et al. A phase II trial of bryostatin 1 in the treatment of metastatic colorectal cancer. Clin Cancer Res 2001;7:38-42.
19. Pagliaro L, Daliani D, Amato R, et al. A Phase II trial of bryostatin-1 for patients with metastatic renal cell carcinoma. Cancer 2000;89:615-8.
20. Dowlati A, Lazarus HM, Hartman P, et al. Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies. Clin Cancer Res 2003;9:5929-35.
21. Kraft AS, Smith JB, Berkow RL. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc Natl Acad Sci U S A 1986;83:1334-8.
22. Szallasi Z, Denning MF, Smith CB, et al. Bryostatin 1 protects protein kinase C-δ from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Mol Pharmacol 1994;46:840-50.
23. Stone RM, Sariban E, Pettit GR, Kufe DW. Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood 1988;72:208-13.
24. Dell'Aquila ML, Nguyen HT, Herald CL, Pettit GR, Blumberg PM. Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells. Cancer Res 1987;47:6006-9.
25. Lee HW, Smith L, Pettit GR, Bingham Smith J. Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin. Am J Physiol 1996;271:C304-11.
26. Isakov N, Galron D, Mustelin T, Pettit GR, Altman A. Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol 1993;150:1195-204.
27. Szallasi Z, Smith CB, Pettit GR, Blumberg PM. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem 1994;269:2118-24.
28. Szallasi Z, Du L, Levine R, et al. The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1. Cancer Res 1996;56:2105-11.
29. Basu A, Akkaraju GR. Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. Biochemistry 1999;38:4245-51.
30. Lorenzo PS, Bogi K, Acs P, Pettit GR, Blumberg PM. The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J Biol Chem 1997;272:33338-43.
31. Lorenzo PS, Bogi K, Hughes KM, et al. Differential roles of the tandem C1 domains of protein kinase Cδ in the biphasic down-regulation induced by bryostatin 1. Cancer Res 1999;59:6137-44.
32. Salge U, Kilian P, Neumann K, Elsasser HP, Havemann K, Heidtmann HH. Differentiation capacity of human non-small-cell lung cancer cell lines after exposure to phorbol ester. Int J Cancer 1990;45:1143-50.
33. Shao L, Lewin NE, Lorenzo PS, et al. Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. J Med Chem 2001;44:3872-80.
34. Gschwend JE, Fair WR, Powell CT. Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase Cα. Mol Pharmacol 2000;57:1224-34.
35. Newton AC. Regulation of protein kinase C. Curr Opin Cell Biol 1997;9:161-7.
36. Axmann A, Seidel D, Reimann T, Hempel U, Wenzel KW. Transforming growth factor-β1-induced activation of the Raf-MEK-MAPK signaling pathway in rat lung fibroblasts via a PKC-dependent mechanism. Biochem Biophys Res Commun 1998;249:456-60.
37. 2+. Biochem J 2001;353:503-12.
38. Hofmann J. Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 2004;4:125-46.
39. Fields AP, Gustafson WC. Protein kinase C in disease: cancer. Methods Mol Biol 2003;233:519-37.
40. Szallasi Z, Krsmanovic L, Blumberg PM. Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res 1993;53:2507-12.
41. Paull KD, Shoemaker RH, Hodes L, et al. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 1989;81:1088-92.
42. Watanabe T, Ono Y, Taniyama Y, et al. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-δ subspecies. Proc Natl Acad Sci U S A 1992;89:10159-63.
43. 1 cyclin expression. J Biol Chem 1997;272:13816-22.
44. Mishima K, Ohno S, Shitara N, Yamaoka K, Suzuki K. Opposite effects of the overexpression of protein kinase C γ and δ on the growth properties of human glioma cell line U251 MG. Biochem Biophys Res Commun 1994;201:363-72.
45. Harrington EO, Loffler J, Nelson PR, Kent KC, Simons M, Ware JA. Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells. J Biol Chem 1997;272:7390-7.
46. Ashton AW, Watanabe G, Albanese C, Harrington EO, Ware JA, Pestell RG. Protein kinase Cδ inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1). J Biol Chem 1999;274:20805-11.
47. Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase Cδ. Apoptosis 2003;8:19-27.
48. Skaletz-Rorowski A, Eschert H, Leng J, et al. PKCδ-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. Cardiovasc Res 2005;67:142-50.
49. Xu J, Rockow S, Kim S, Xiong W, Li W. Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells. Mol Cell Biol 1994;14:8018-27.
50. 1 is required for DNA synthesis in serum-induced cell cycle progression. Genes Cells 2003;8:311-24.
51. Clark AS, West KA, Blumberg PM, Dennis PA. Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance. Cancer Res 2003;63:780-6.
52. Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. J Dermatol Sci 1998;17:1-7.
53. Steinberg SF. Distinctive activation mechanisms and functions for protein kinase Cδ. Biochem J 2004;384:449-59.
54. Kikkawa U, Matsuzaki H, Yamamoto T. Protein kinase Cδ (PKCδ): activation mechanisms and functions. J Biochem (Tokyo) 2002;132:831-9.
55. Tortora G, Ciardiello F. Antisense strategies targeting protein kinase C: preclinical and clinical development. Semin Oncol 2003;30:26-31.
56. Pu Y, Perry NA, Yang D, et al. A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms α and δ as well as selectivity for RasGRP compared with PKCα. J Biol Chem 2005;280:27329-38.