Glutamate release inhibiting properties of the novel mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): Complementary in vitro and in vivo evidence

Neuropharmacology

Volumn 41, Issue 4, 2001, Pages 523-527

  Thomas, Lisa S ^a   Jane, David E ^b   Gasparini, Fabrizio ^c   Croucher, Martin J ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b Dept Anat Sch Med Sci U   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Autoreceptors; Glutamate; Metabotropic glutamate receptors; MPEP; Presynaptic

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; AUTORECEPTOR; GLUTAMIC ACID; METABOTROPIC GLUTAMATE 5 RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT;

ANIMALS; BRAIN CHEMISTRY; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; MALE; MICRODIALYSIS; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, KAINIC ACID; RESORCINOLS;

EID: 0034861333     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00091-0     Document Type: Article

References (14)

1. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice
2. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
3. Pharmacology and functions of metabotropic glutamate receptors
4. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
5. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
6. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
7. Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat brain
8. A role for presynaptic group I metabotropic glutamate receptors in the control of glutamate release in the rat striatum: An in vivo microdialysis study
9. Presynaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: A dual-label microdialysis study
10. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
11. The metabotropic glutamate receptor 1 is not involved in the facilitation of glutamate release in cerebrocortical nerve terminals
12. 5 sub-type positively modulate neuronal glutamate release in the rat forebrain in vitro
13. N-Methyl-D-aspartate releases γ-aminobutyric acid from rat striatum in vivo: A microdialysis study using a novel preloading method
14. Preloading in vivo: A rapid and reliable method for measuring γ-aminobutyric acid and glutamate fluxes by microdialysis