Pharmacogenetic and metabolic differences between dog breeds: Their impact on canine medicine and the use of the dog as a preclinical animal model

AAPS Journal

Volumn 10, Issue 1, 2008, Pages 110-119

  Fleischer, Steven ^a   Sharkey, Michele ^a   Mealey, Katrina ^a   Ostrander, Elaine A ^a   Martinez, Marilyn ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bioavailability; Breed related differences; Canine pharmacodynamics; Canine pharmacogenetics; Canine pharmacokinetics; Drug response; Population diversity

Indexed keywords

ATROPINE; CISAPRIDE; COLECALCIFEROL; GLYCOPYRRONIUM BROMIDE; METOCLOPRAMIDE; SOMATOMEDIN C; SULFONAMIDE;

ANIMAL GENETICS; BREED DIFFERENCE; DOG; DRUG DOSE COMPARISON; DRUG RESPONSE; GENETIC DISORDER; GENETIC PREDISPOSITION; GENETIC TRAIT; GENOME ANALYSIS; GENOTYPE; HUMAN VERSUS ANIMAL COMPARISON; INHERITANCE; LOW DRUG DOSE; METABOLIC PARAMETERS; NONHUMAN; PEDIGREE; PHARMACOGENETICS; PHENOTYPE; POPULATION GENETICS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TOXICITY TESTING; VITAMIN METABOLISM;

ANIMALS; DOGS; DRUG EVALUATION, PRECLINICAL; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; PHARMACOGENETICS; SPECIES SPECIFICITY; VETERINARY MEDICINE;

EID: 51249095834     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-008-9011-1     Document Type: Review

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