Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 318-327

  Hwang, Yong Pil ^a   Kim, Hyung Gyun ^a   Han, Eun Hee ^a   Jeong, Hye Gwang ^a  

^a Chosun University   (South Korea)

Author keywords

ERK kinase; Heme oxygenase 1; Metallothionein III; neuroprotection; NF E2 related factor 2; Parkinson's disease; Phosphatidylinositol 3 kinase

Indexed keywords

BETA ACTIN; CASPASE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; METALLOTHIONEIN III; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTOXIN; OXIDOPAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ZINC BINDING PROTEIN;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NERVE CELL LESION; NEUROPROTECTION; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HUMANS; NERVE TISSUE PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDOPAMINE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 51049095124     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.04.019     Document Type: Article

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