New technique for high-throughput synthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 9, 1999, Pages 1305-1310

  Lebl, Michal ^a  

^a Spyder Instruments Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPROPYLENE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CENTRIFUGATION; CHEMICAL REACTION; FILTRATION; PHASE SEPARATION; SYNTHESIS;

CENTRIFUGATION; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; QUINOLONES;

EID: 0033519181     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00176-6     Document Type: Article

References (9)

1. Leblova, Z.; Lebl, M. Compilation of Papers in Molecular Diversity Field. Internet: http://www.5z.com/divinfo.
2. Cargill, J. F.; Lebl, M. Curr. Opin. Chem. Biol. 1997, 1, 67.
3. Lebl, M.; Krchnák, V. Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries; Epton, R. Ed. Mayflower Scientific Limited: Birmingham, 1998, in press.
4. Krchnák, V.; Weichsel, A. S.; Lebl, M.; Felder, S. Bioorg. Med. Chem. Lett. 1997, 7, 1013.
5. Technique was first presented at LabAutomation 98 conference: Lebl, M. J. Assoc. Lab. Autom. 1998, 3, 59.
6. Griffith, M. C.; Dooley, C. T.; Houghten, R. A.; Kiely, J. S. In: Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. Chaiken, I. M., Janda. K. D., editors. Washington, DC: American Chemical Society; 1996. p 50-7.
7. Houghten, R. A. Proc. Natl. Acad. Sci. USA 1985, 82, 5131.
8. List of building blocks used in the first and the second step of the synthesis of 380 tetrahydroisoquinolinones. Amino acids: glycine, 3-aminopropionic acid, 5-aminopentanoic acid, 7-aminoheptanoic acid, (S)2,3-diaminopropionic acid, (S)2,6-diaminohexanoic acid, (S/R)-3-amino-2-methylpropionic acid, 2-(2-aminoethoxy)acetic acid, trans-4-(aminomethyl)cyclohexanecarboxylic acid, 4-(aminomethyl)benzoic acid; Aldehydes: benzaldehyde, 1,4-benzodioxan-6-carboxaldehyde,1-methylindole-3-carboxaldehyde, 2,3-difluorobenzaldehyde, 2-bromobenzaldehyde, 2-chloro-5-nitrobenzaldehyde, 2-furaldehyde, 2-imidazolecarboxaldehyde, 2-naphthaldehyde, 2-pyridinecarboxaldehyde, 2-thiophenecarboxaldehyde, 3,4-dichlorobenzaldehyde, 3,5-bis(trifluoromethyl)benzaldehyde, 3,5-dihydroxybenzaldehyde, 3,5-dimethoxybenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 3-(4-methoxyphenoxy)benzaldehyde, 3-furaldehyde, 3-hydroxybenzaldehyde, 3-methyl-4-methoxybenzaldehyde, 3-methylbenzaldehyde, 3-nitrobenzaldehyde, 3-pyridinecarboxaldehyde, 3-thiophenecarboxaldehyde, 4-(3-dimethylaminopropoxy)benzaldehyde, 4-(dimethylamino)benzaldehyde, 4-(methylthio)benzaldehyde, 4-(trifluoromethyl)benzaldehyde, 4-biphenylcarboxaldehyde, 4-bromo-2-thiophenecarboxaldehyde, 4-cyanobenzaldehyde, 4-methoxy-1-naphthaldehyde, 4-nitrobenzaldehyde, 4-pyridinecarboxaldehyde, 5-(hydroxymethyl)-2-furaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 5-nitro-2-furaldehyde, 6-methyl-2-pyridinecarboxaldehyde.
9. Krchnák, V.; Vágner, J.; Safár, P.; Lebl, M. Collect. Czech. Chem. Commun. 1988, 53, 2542.