Nutrigenomics and selenium: Gene expression patterns, physiological targets, and genetics

Annual Review of Nutrition

Volumn 28, Issue , 2008, Pages 157-177

  Hesketh, John ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Nutrient gene interactions; Selenoproteins; SNP; Transcriptomics

Indexed keywords

ALPHA TOCOPHEROL; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE PEROXIDASE 6; METHYLSELENINIC ACID; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROSTAGLANDIN E RECEPTOR; SELENIUM; SELENIUM DERIVATIVE; SELENOCYSTEINE; SELENOMETHIONINE; SELENOPROTEIN; SELENOPROTEIN H; SELENOPROTEIN L; SELENOPROTEIN N; SELENOPROTEIN S; SELENOPROTEIN W; SEPP PROTEIN; SODIUM SELENITE; T CELL FACTOR PROTEIN; T CELL FACTOR PROTEIN 7; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; BREAST CANCER; CANCER MORTALITY; CELL CYCLE REGULATION; CELL GROWTH; DIETARY INTAKE; DISEASE PREDISPOSITION; ESOPHAGUS DISEASE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENETIC VARIABILITY; GROWTH INHIBITION; HEALTH STATUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MISSENSE MUTATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUTRIENT DYNAMICS; NUTRIENT GENE INTERACTION; NUTRIGENOMICS; ONCOGENE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN SYNTHESIS; RAT; RECOMMENDED DRUG DOSE; REVIEW; SBP2 GENE; SECIS GENE; SELENIUM INTAKE; SELENOCYSTEINE INSERTION SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; VAV2 GENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NUTRIGENOMICS; NUTRITIONAL REQUIREMENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; SELENIUM; SELENOPROTEINS;

ANIMALIA;

EID: 50949099632     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.28.061807.155446     Document Type: Review

References (108)

1. Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. 2007. Structural analysis of seleno-protein W and NMR analysis of its interaction with 14-3-3 proteins. J. Biol. Chem. 282:37036-44
2. Akbaraly NT, Arnaud J, Hininger-Favier I, Gourlet V, Roussel AM, et al. 2005. Selenium and mortality in the elderly: results from the EVA study. Clin. Chem. 51:2117-23
3. Al-Taie OH, Seufert J, Mork H, Treis H, Mentrup B, et al. 2002. A complex DNA-repeat structure within the selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency. Eur. J. Hum. Genet. 10:499-504
4. Al-Taie OH, Uceyler N, Eubner U, Jakob F, Mork H, et al. 2004. Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutr. Cancer 48:6-14
5. Allamand V, Richard P, Lescure A, Ledeuil C, Desjardin D, et al. 2006. A single homozygous point mutation in a 3′untranslated region motif of selenoprotein N mRNA causes SEPN1-related myopathy. EMBO Rep. 7:450-54
6. Arbones-Mainar JM, Ross K, Rucklidge GJ, Reid M, Duncan G, et al. 2007. Extra virgin olive oils increase hepatic fat accumulation and hepatic antioxidant protein levels in APOE(-/-) mice. J. Proteome Res. 6:4041-54
7. Apostolou S, Klein JO, Mitsuuchi Y, Shetler JN, Poulikakos PI, et al. 2004. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. Oncogene 23:5032-40
8. Arnér ES, Holmgren A. 2006. The thioredoxin system in cancer. Semin. Cancer Biol. 16:420-26
9. Beck MA, Esworthy RS, Ho YS, Chu FF. 1998. Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J. 12:1143-49
10. Beck MA, Levander OA, Handy J. 2003. Selenium deficiency and viral infection. J. Nutr. 133:1463-67S
11. Beckett GJ, Arthur JR. 2005. Selenium and endocrine systems. J. Endocrinol. 184:455-65
12. Behne D, Hilmert H, Scheid S, Gessner H, Elger W. 1988. Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim. Biophys. Acta 966:12-21
13. Bermano G, Nicol F, Dyer JA, Sunde RA, Beckett GJ, et al. 1995. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem. J. 311:425-30
14. Bermano G, Arthur JR, Hesketh JE. 1996. Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply. FEBS Lett. 387:157-60
15. Bermano G, Arthur JR, Hesketh JE. 2006. Role of the 3′ untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply. Biochem. J. 320:891-95
16. Bermano G, Pagmanditis V, Holloway N, Kadri S, Mowat NAG, et al. 2007. Evidence that a polymorphism within the 3′UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Genes Nutr. 2:227-32
17. Brigelius-Flohé R. 1999. Tissue-specific functions of individual glutathione peroxidases. Free Radic. Biol. Med. 27:951-65
18. Brigelius-Flohé R. 2006. Glutathione peroxidases and redox-regulated transcription factors. Biol. Chem. 387:1329-35
19. Brigelius-Flohé R, Joost H-G, eds. 2006. Nutritional Genomics. Weinheim, Germ.: Wiley-VCH Verlag
20. Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, et al. 2004. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am. J. Clin. Nutr. 80:154-62
21. Burk RF, Hill KE. 2005. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu. Rev. Nutr. 25:215-35
22. Burk RF, Hill KE, Motley AK. 2003. Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J. Nutr. 133:1517-20S
23. Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, et al. 2007. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J. Neurosci. 27:6207-11
24. Cao TM, Hua FY, Xu CM, Han BS, Dong H, et al. 2006. Distinct effects of different concentrations of sodium selenite on apoptosis, cell cycle, and gene expression profile in acute promyelocytic leukemia-derived NB4 cells. Ann. Hematol. 85:434-42
25. Carlson BA, Moustafa ME, Sengupta A, Schweizer U, Shrimali R, et al. 2007. Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J. Biol. Chem. 282:32591-602
26. Chavatte L, Brown BA, Driscoll DM. 2005. Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes. Nat. Struct. Mol. Biol. 12:408-16
27. Chu FF, Esworthy RS, Chu PG, Longmate JA, Huycke MM, et al. 2004. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res. 64:962-68
28. Clark LC, Combs GF Jr, Turnbull BW, Slate EH, Chalker DK, et al. 1996. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276:1957-63
29. Copeland PR, Stepanik VA, Driscoll DM. 2001. Insight into mammalian selenocysteine insertion: domain structure and ribosome binding properties of Sec insertion sequence binding protein 2. Mol. Cell Biol. 21:1491-98
30. Cox DG, Hankinson SE, Kraft P, Hunter DJ. 2004. No association between GPX1 Pro198Leu and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 13:1821-22
31. Cox DG, Tamimi RM, Hunter DJ. 2006. Gene x gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study. BMC Cancer 6:217
32. Curran JE, Jowett JB, Elliott KS, Gao Y, Gluschenko K, et al. 2005. Genetic variation in selenoprotein S influences inflammatory response. Nat. Genet. 37:1234-41
33. Crosley LK, Méplan C, Nicol F, Rundlöf AK, Arnér ES, et al. 2007. Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney. Arch. Biochem. Biophys. 459:178-88
34. Diaconu M, Tangat Y, Böhm D, Kühn H, Michelmann HW, et al. 2006. Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene. Andrologia 38:152-57
35. Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, et al. 2007. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry 46:6871-82
36. Diwadkar-Navsariwala V, Prins GS, Swanson SM, Birch LA, Ray VH, et al. 2006. Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. Proc. Natl. Acad. Sci. USA 103:8179-84
37. Dong Y, Ganther HE, Stewart C, Ip C. 2002. Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Res. 62:708-14
38. Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C. 2003. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res. 63:52-59
39. Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, et al. 2005. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat. Genet. 37:1247-52
40. El-Bayoumy K, Sinha R. 2005. Molecular chemoprevention by selenium: a genomic approach. Mut. Res. 591:224-36
41. Elliott R, Pico C, Dommels Y, Wybranska I, Hesketh J, Keijer J. 2007. Nutrigenomic approaches for benefit-risk analysis of foods and food components: defining markers of health. Br. J. Nutr. 98:1095-100
42. Evenson JK, Wheeler AD, Blake SM, Sunde RA. 2004. Selenoprotein mRNA is expressed in blood at levels comparable to major tissues in rats. J. Nutr. 134:2640-45
43. Fagegaltier D, Hubert N, Yamada K, Mizutani T, Carbon P, et al. 2000. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. EMBO J. 19:4796-805
44. Fan TW, Higashi RM, Lane AN. 2006. Integrating metabolomics and transcriptomics for probing Se anticancer mechanisms. Drug Metab. Rev. 38:707-32
45. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, et al. 2006. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J. Biol. Chem. 281:3536-43
46. Fischer A, Pallauf J, Gohil K, Weber SU, Packer L, et al. 2001. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochem. Biophys. Res. Commun. 285:470-75
47. Forsberg L, de Faire U, Marklund SL, Andersson PM, Stegmayr B, Morgenstern R. 2000. Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. Blood Cells Mol. Dis. 26:423-26
48. Foster CB, Aswath K, Chanock SJ, McKay HF, Peters U. 2006. Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations. BMC Genet. 7:56
49. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, et al. 2004. Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. FEBS Lett. 563:185-90
50. Gu QP, Ream W, Whanger PD. 2002. Selenoprotein W gene regulation by selenium in L8 cells. Biometals 15:411-20
51. Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, et al. 2004. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes 53:2455-60
52. Hatfield DL, Gladyshev VN. 2002. How selenium has altered our understanding of the genetic code. Mol. Cell Biol. 22:3565-76
53. Hill KE, Zhou J, Austin LM, Motley AK, Ham AJ, et al. 2007. The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium. J. Biol. Chem. 282:10972-80
54. Hoffmann PR, Höge SC, Li PA, Hoffmann FW, Hashimoto AC, et al. 2007. The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Nucleic Acids Res. 35:3963-73
55. Hooven LA, Buder J, Ream LW, Whanger PD. 2006. Microarray analysis of selenium-depleted and selenium-supplemented mice. Biol. Trace Elem. Res. 109:173-79
56. Hu YJ, Diamond AM. 2003. Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer Res. 63:3347-51
57. Hu YJ, Korotkov KV, Mehta R, Hatfield DL, Rotimi CN, et al. 2001. Distribution and functional consequences of nucleotide polymorphisms in the 3′-untranslated region of the human Sep15 gene. Cancer Res. 61:2307-10
58. Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C, et al. 2004. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. J. Urol. 172:728-32
59. Irons R, Carlson BA, Hatfield DL, Davis CD. 2006. Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression. J. Nutr. 136:1311-17
60. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY. 2002. Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Lett. 517:225-28
61. Joshi N, Johnson LL, Wei WQ, Abnet CC, Dong ZW, et al. 2006. Selenomethionine treatment does not alter gene expression in normal squamous esophageal mucosa in a high-risk Chinese population. Cancer Epidemiol. Biomarkers Prev. 15:1046-47
62. Joost HG, Gibney MJ, Cashman KD, Gorman U, Hesketh JE, et al. 2007. Personalised nutrition: status and perspectives. Br. J. Nutr. 98:26-31
63. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, et al. 2003. Characterization of mammalian selenoproteomes. Science 300:1439-43
64. Lei XG, Cheng WH, McClung JP. 2007. Metabolic regulation and function of glutathione peroxidase-1. Annu. Rev. Nutr. 27:41-61
65. Lei XG, Evenson JK, Thompson KM, Sunde RA. 1995. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J. Nutr. 125:1438-46
66. Low SC, Berry MJ. 1996. Knowing when not to stop: selenocysteine incorporation in eukaryotes. Trends Biochem. Sci. 21:203-8
67. Low SC, Grundner-Culemann E, Harney JW, Berry MJ. 2000. SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. EMBO J. 19:6882-90
68. Maiorino M, Bosello V, Ursini F, Foresta C, Garolla A, et al. 2003. Genetic variations of gpx-4 and male infertility in humans. Biol. Reprod. 68:1134-41
69. Méplan C, Crosley LK, Nicol F, Beckett GJ, Howie AF, et al. 2007. Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study). FASEB J. 21:3063-74
70. Méplan C, Crosley LK, Nicol F, Horgan G, Mathers JC, et al. 2008. Functional effectf of a common single nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with gender. Am. J. Clin. Nutr. 87:1019-27
71. Méplan C, Pagmantidis V, Hesketh JE. 2006. Advances in selenoprotein expression-patterns and individual variations. In Nutritional Genomics, ed. R Brigelius-Flohé, H-G Joost, pp 132-58. Weinheim. Germ.: Wiley-VCH Verlag
72. Moghadaszadeh B, Petit N, Jaillard C, Brockington M, Roy SQ, et al. 2001. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Nat. Genet. 29:17-18
73. Moscow JA, Morrow CS, He R, Mullenbach GT, Cowan KH. 1992. Structure and function of the 5′-flanking sequence ofthe human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). J. Biol. Chem. 267:5949-58
74. Moustafa ME, Carlson BA, El-Saadani MA, Kryukov GV, Sun QA, et al. 2001. Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Mol. Cell Biol. 21:3840-52
75. Müller C, Wingler K, Brigelius-Flohé R. 2003. 3′UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency. Biol. Chem. 384:11-18
76. Ordovas JM. 2006. Nutrigenetics, plasma lipids, and cardiovascular risk. J. Am. Diet. Assoc. 106:1074-81
77. Pagmantidis V, Bermano G, Villette S, Broom I, Arthur J, Hesketh J. 2005. Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 579:792-96
78. Pagmantidis V, Méplan C, van Schothorst EM, Keijer J, Hesketh J. 2008. Supplementation of healthy volunteers with nutritionally relevant levels of selenium increases expression of lymphocyte protein biosynthesis genes. Am. J. Clin. Nutr. 87:181-89
79. Panee J, Stoytcheva ZR, Liu W, Berry MJ. 2007. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. J. Biol. Chem. 282:23759-65
80. Qatatsheh A, Seal CJ, Jowet SL, Welfare MR, Hesketh JE. 2005. Patients with ulcerative colitis show an altered frequency distribution of a single nucleotide polymorphism (SNP) in the gene encoding phospholipid hydroperoxide glutathione peroxidise (GPx4). Proc. Nutr. Soc. 64:20A (Abst.)
81. Raaschou-Nielsen O, Sørensen M, Hansen RD, Frederiksen K, Tjønneland A, et al. 2007. GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Cancer Lett. 247:293-300
82. Ran Q, Liang H, Gu M, Qi W, Walter CA, et al. 2004. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J. Biol. Chem. 279:55137-46
83. Ratnasinghe D, Tangrea JA, Andersen MR, Barrett MJ, Virtamo J, et al. 2000. Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Cancer Res. 60:6381-83
84. Ravn-Haren G, Olsen A, Tjønneland A, Dragsted LO, Nexø BA, et al. 2006. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis 27:820-25
85. Ray AL, Semba RD, Walston J, Ferrucci L, Cappola AR, et al. 2006. Low serum selenium and total carotenoids predict mortality among older women living in the community: the Women's Health and Aging Studies. J. Nutr. 136:172-76
86. Rayman MP. 2002. The argument for increasing selenium intake. Proc. Nutr. Soc. 61:203-15
87. Renko K, Werner M, Renner-Müller I, Cooper TG, Yeung CH, et al. 2008. Hepatic selenoprotein P (Sepp) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Biochem. J. 409:741-49
88. Saito Y, Sato N, Hirashima M, Takebe G, Nagasawa S, et al. 2004. Domain structure of bi-functional selenoprotein P. Biochem. J. 381:841-46
89. Saito Y, Takahashi K. 2002. Characterization of selenoprotein P as a selenium supply protein. Eur. J. Biochem. 269:5746-51
90. Schlicht M, Matysiak B, Brodzeller T, Wen X, Liu H, et al. 2004. Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. BMC Genomics 5:58
91. Seiderer J, Dambacher J, Kühnlein B, Pfennig S, Konrad A, et al. 2007. The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. Tissue Antigens 70:238-46
92. Shchedrina VA, Novoselov SV, Malinouski MY, Gladyshev VN. 2007. Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc. Natl. Acad. Sci. USA 104:13919-24
93. Sheridan PA, Zhong N, Carlson BA, Perella CM, Hatfield DL, et al. 2007. Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J. Nutr. 137:1466-71
94. Stadtman TC. 1996. Selenocysteine. Annu. Rev. Biochem. 65:83-100
95. Udler M, Maia AT, Cebrian A, Brown C, Greenberg D, et al. 2007. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J. Clin. Oncol. 25:3015-23
96. van Erk MJ, Blom WA, van Ommen B, Hendriks HF. 2006. High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells. Am. J. Clin. Nutr. 84:1233-41
97. Villette S, Kyle JA, Brown KM, Pickard K, Milne JS, et al. 2002. A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells Mol. Dis. 29:174-78
98. Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, et al. 2007. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke 38:41-49
99. Whanger PD. 2004. Selenium and its relationship to cancer: an update dagger. Br. J. Nutr. 91:11-28
100. Wingler K, Bocher M, Flohe L, Kollmus H, Brigelius-Flohe R. 1999. mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins. Eur. J. Biochem. 259:149-57
101. Xu XM, Carlson BA, Irons R, Mix H, Zhong N, et al. 2007. Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem. J. 404:115-20
102. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, et al. 2007. Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 5:e4
103. Yoo MH, Xu XM, Turanov AA, Carlson BA, Gladyshev VN, et al. 2007. A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3′-UTR. RNA 13:921-29
104. Zeisel SH. 2007. Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am. J. Clin. Nutr. 86:542-48
105. Zhao H, Whitfield ML, Xu T, Botstein D, Brooks JD. 2004. Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Mol. Biol. Cell 15:506-19
106. Bleys J, Navas-Acien A, Guallar E. 2008. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch. Intern. Med. 168:404-10. Suggests that the optimal Se intake is one that gives a serum Se of ∼130 ng/ml
107. Haggarty P. 2007. B-vitamins, genotype and disease causality. Proc. Nutr. Soc. 66:539-47. Discusses approaches to study of nutrient-gene interactions
108. Jablonska E, Gromadzinska J, Sobala W, Reszka E, Wasowicz W. 2008. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. Eur. J. Nutr. 47:47-54. Suggests that in smokers, SNPs in the selenoprotein 15 gene influence lung cancer risk