Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)

FASEB Journal

Volumn 21, Issue 12, 2007, Pages 3063-3074

  Méplan, Catherine ^a   Crosley, Lynne K ^e   Nicol, Fergus ^e   Beckett, Geoffrey J ^b   Howie, Alexander F ^b   Hill, Kristina E ^c   Horgan, Graham ^d   Mathers, John C ^a   Arthur, John R ^e   Hesketh, John E ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BioSS   (United Kingdom)

^e ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

3 untranslated region; BMI; Nutrient gene interaction

Indexed keywords

ALANINE; CELL MARKER; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 4; SELENOPROTEIN P; SODIUM SELENITE; THIOREDOXIN REDUCTASE; THREONINE; TRACE ELEMENT; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GPX3 PROTEIN, HUMAN; OSTEOPROTEGERIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENIUM; TNFRSF11B PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CAUCASIAN; CHINESE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE PREDISPOSITION; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; SEPP GENE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH ASIA; BLOOD; BLOOD CELL; ETHNIC GROUP; GENETICS; METABOLISM; MIDDLE AGED; RANDOMIZATION; UNITED KINGDOM;

ADULT; BIOLOGICAL MARKERS; BLOOD CELLS; DIETARY SUPPLEMENTS; DISEASE SUSCEPTIBILITY; ETHNIC GROUPS; FEMALE; GENOTYPE; GLUTATHIONE PEROXIDASE; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; OSTEOPROTEGERIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOM ALLOCATION; SELENIUM; SELENOPROTEIN P; SEX FACTORS;

EID: 35248826128     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-8166com     Document Type: Article

References (36)

1. Rayman, M. P. (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc. Nutr. Soc. 64, 527-542
2. Beckett, G. J., and Arthur, J. R. (2005) Selenium and endocrine systems. J. Endocrinol. 184, 455-465
3. Stadtman, T. C. (1990) Selenium biochemistry. Annu. Rev. Biochem. 59, 111-127
4. Méplan, C., Pagmantidis, V., and Hesketh, J. E. (2006) Advances in selenoprotein expression - patterns and individual variations. In Nutritional Genomics, Nutrients, Genes and Genetic Variation in Health and Diseas. (Brigelius-Flohe, R. and Joost H.-G., eds) pp. 132-158, Wiley-VCH, Weinheim, Germany
5. Small-Howard, A. L., and Berry, M. J. (2005) Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes. Biochem. Soc. Trans. 33, 1493-1497
6. Allan, C. B., Lacourciere, G. M., and Stadtman, T. C. (1999) Responsiveness of selenoproteins to dietary selenium. Annu. Rev. Nutr. 19, 1-16
7. Bermano, G., Nicol, F., Dyer, J. A., Sunde, R. A., Beckett, G. J., Arthur, J. R., and Hesketh, J. E. (1995) Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem. J. 311, 425-430
8. Combs, G. F., Jr. (2005) Current evidence and research needs to support a health claim for selenium and cancer prevention. J. Nutr. 135, 343-347
9. Whanger, P. D. (2004) Selenium and its relationship to cancer: an update dagger. Br. J. Nutr. 91, 11-28
10. Akbaraly, N. T., Arnaud, J., Hininger-Favier, I., Gourlet, V., Roussel, A. M., and Berr, C. (2005) Selenium and mortality in the elderly: results from the EVA study. Clin. Chem. 51, 2117-2123
11. Ray, A. L., Semba, R. D., Walston, J., Ferrucci, L., Cappola, A. R., Ricks, M. O., Xue, Q. L., and Fried, L. P. (2006) Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studies. J. Nutr. 136, 172-176
12. Xia, Y., Hill, K. E., Byrne, D. W., Xu, J., and Burk, R. F. (2005) Effectiveness of selenium supplements in a low-selenium area of China. Am. J. Clin. Nutr. 81, 829-834
13. Rayman, M. P. (2000) The importance of selenium to human health. Lancet 356, 233-241
14. Wolters, M., Hermann, S., Golf, S., Katz, N., and Hahn, A. (2006) Selenium and antioxidant vitamin status of elderly German women. Eur. J. Clin. Nutr. 60, 85-91
15. Hill, K. E., Zhou, J., McMahan, W. J., Motley, A. K., Atkins, J. F., Gesteland, R. F., and Burk, R. F. (2003) Deletion of selenoprotein P alters distribution of selenium in the mouse. J. Biol. Chem. 278, 13640-13646
16. Schomburg, L., Schweizer, U., Holtmann, B., Flohe, L., Sendtner, M., and Kohrle, J. (2003) Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem. J. 370, 397-402
17. Hill, K. E., Zhou, J., McMahan, W. J., Motley, A. K., and Burk, R. F. (2004) Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J. Nutr. 134, 157-161
18. Schweizer, U., Brauer, A. U., Kohrle, J., Nitsch, R., and Savaskan, N. E. (2004) Selenium and brain function: a poorly recognized liaison. Brain Res. Rev. 45, 164-178
19. Schweizer, U., Streckfuss, F., Pelt, P., Carlson, B. A., Hatfield, D. L., Kohrle, J., and Schomburg, L. (2005) Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. Biochem. J. 386, 221-226
20. Burk, R. F., and Hill, K. E. (2005) Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu. Rev. Nutr. 25, 215-235
21. Maehara, S., Tanaka, S., Shimada, M., Shirabe, K., Saito, Y., Takahashi, K., and Maehara, Y. (2004) Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells. Int. J. Cancer 112, 184-189
22. Steinbrenner, H., Alili, L., Bilgic, E., Sies, H., and Brenneisen, P. (2006) Involvement of selenoprotein P in protection of human astrocytes from oxidative damage. Free Radic. Biol. Med. 40, 1513-1523
23. Saito, Y., Sato, N., Hirashima, M., Takebe, G., Nagasawa, S., and Takahashi, K. (2004) Domain structure of bi-functional selenoprotein P. Biochem. J. 381, 841-846
24. Hirashima, M., Naruse, T., Maeda, H., Nozaki, C., Saito, Y., and Takahashi, K. (2003) Identification of selenoprotein P fragments as a cell-death inhibitory factor. Biol. Pharm Bull 26, 794-798
25. Al-Taie, O. H., Uceyler, N., Eubner, U., Jakob, F., Mork, H., Scheurlen, M., Brigelius-Flohe, R., Schottker, K., Abel, J., Thalheimer, A., et al. (2004) Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutr. Cancer 48, 6-14
26. Bhopal, R., Unwin, N., White, M., Yallop, J., Walker, L., Alberti, K. G., Harland, J., Patel, S., Ahmad, N., Turner, C., et al. (1999) Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ 319, 215-220
27. Fischbacher, C. M., White, M., Bhopal, R., Unwin, N., and Alberti, K. G. (2002) Newcastle heart project. J. Epidemiol. Community Health 56, 79
28. Paglia, D. E., and Valentine, W. N. (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158-169
29. Brown, K. M., Pickard, K., Nicol, F., Beckett, G. J., Duthie, G. G., and Arthur, J. R. (2000) Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphoctyes, granulocytes, platelets and erythrocytes. Clin. Sci. (Lond.) 98, 593-599
30. Weitzel, F., Ursini, F., and Wendel, A. (1990) Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion. Biochim. Biophys. Acta 1036, 88-94
31. Miller, S., Walker, S. W., Arthur, J. R., Nicol, F., Pickard, K., Lewin, M. H., Howie, A. F., and Beckett, G. J. (2001) Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin. Sci. (Lond). 100, 543-550
32. Burk, R. F., Norsworthy, B. K., Hill, K. E., Motley, A. K., and Byrne, D. W. (2006) Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol. Biomarkers Prev. 15, 804-810
33. Broome, C. S., McArdle, F., Kyle, J. A., Andrews, F., Lowe, N. M., Hart, C. A., Arthur, J. R., and Jackson, M. J. (2004) An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am. J. Clin. Nutr. 80, 154-162
34. Rayman, M. P. (2004) The use of high-selenium yeast to raise selenium status: how does it measure up? Br. J. Nutr. 92, 557-573
35. Weiss, S. L., Evenson, J. K., Thompson, K. M., and Sunde, R. A. (1996) The selenium requirement for glutathione peroxidase mRNA level is half of the selenium requirement for glutathione peroxidase activity in female rats. J. Nutr. 126, 2260-2267
36. Riese, C., Michaelis, M., Mentrup, B., Gotz, F., Kohrle, J., Schweizer, U., and Schomburg, L. (2006) Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues. Endocrinology 147, 5883-5892