Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 5, 2008, Pages 805-811

  Fujita, Masaki ^a,b   Mizuta, Yuichi ^a   Ikegame, Satoshi ^a   Ouchi, Hiroshi ^a   Ye, Qing ^a   Harada, Eiji ^a   Inoshima, Ichiro ^a   Yoshimi, Michihiro ^a   Watanabe, Kentaro ^b   Nakanishi, Yoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

DNA damage; Lung injury; Oxygen radical

Indexed keywords

BLEOMYCIN; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYPROLINE; NORPHENAZONE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DNA DAMAGE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; FLOW CYTOMETRY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; ANTIPYRINE; APOPTOSIS; BLEOMYCIN; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; DEOXYGUANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FREE RADICAL SCAVENGERS; HYDROXYPROLINE; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; INTUBATION, INTRATRACHEAL; LIPID PEROXIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; TIME FACTORS;

EID: 50849141668     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.06.006     Document Type: Article

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