Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 2, 2006, Pages 739-743

  Fujita, Masaki ^a   Ye, Qing ^a   Ouchi, Hiroshi ^a   Harada, Eiji ^a   Inoshima, Ichiro ^a   Kuwano, Kazuyoshi ^a   Nakanishi, Yoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; DOXYCYCLINE; GELATINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; LUNG FIBROSIS; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; BLEOMYCIN; DOXYCYCLINE; FEMALE; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS;

EID: 31944448350     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.2.739-743.2006     Document Type: Article

References (24)

1. Abe, S., H. Nakamura, S. Inoue, H. Takeda, H. Saito, S. Kato, N. Mukaida, K. Matsushima, and H. Tomoike. 2001. Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding sites in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 22:51-60.
2. Atkinson, J. J., and R. M. Senior. 2003. Matrix metalloproteinase-9 in lung remodeling. Am. J. Respir. Cell Mol. Biol. 28:12-24.
3. Azoulay, E., S. Herigault, M. Levame, L. Brochard, B. Schlemmer, A. Harf, and C. Deldaux. 2003. Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis. Crit. Care Med. 31:1442-1448.
4. Bakowska, J., and I. Y. Adamson. 1998. Collagenase and gelatinase activities in bronchoalveolar lavage fluids during bleomycin-induced lung injury. J. Pathol. 185:319-323.
5. Carney, D., C. Lutz, A. Picone, L. Gatto, N. Ramamurthy, L. Golub, S. Simon, B. Searles, A. Paskanik, K. Snyder, C. Finck, H. Schiller, and G. Nieman. 1999. Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass. Circulation 100:400-406.
6. Clark, J. G., and C. Kuhn III. 1982. Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis. Am. Rev. Respir. Dis. 126:737-739.
7. Corbel, M., S. Caulet-Maugendre, N. Germain, S. Molet, V. Lagente, and E. Boichot. 2001. Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat. J. Pathol. 193:538-545.
8. Curci, J., D. Mao, D. Bohner, B. Allen, B. Rubin, J. Reilly, G. Sicard, and R. Thompson. 2000. Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms. J. Vasc. Surg. 31:325-342.
9. Fujita, M., J. M. Shannon, C. G. Irvin, K. A. Fagan, C. Cool, A. Augustin, and R. J. Mason. 2001. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L39-L49.
10. Fujita, M., J. M. Shannon, O. Morikawa, J. Gauldie, N. Hara, and R. J. Mason. 2003. Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta. Am. J. Respir. Cell Mol. Biol. 29:669-676.
11. Fujita, M., J. M. Shannon, H. Ouchi, D. R. Voelker, Y. Nakanishi, and R. J. Mason. 2005. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 31:25-33.
12. Fukuda, Y., M. Ishizaki, S. Kudoh, M. Kitaichi, and N. Yamanaka. 1998. Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. Lab. Investig. 78:687-698.
13. Iwasaki, H., H. Inoue, Y. Mituke, A. Badran, S. Ikegaya, and T. Ueda. 2002. Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells. J. Lab. Clin. Med. 140:382-386.
14. Jain, A., L. Sangal, E. Basal, G. P. Kaushal, and S. K. Agarwal. 2002. Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. Dermatol. Online J. 8:2. [Online.] http: //dermatology.cdlib. org/DOJvol8num2/original/antibiotics2/jain.html.
15. Kuwano, K., N. Hagimoto, T. Maeyama, M. Fujita, M. Yoshimi, I. Inoshima, N. Nakashima, N. Hamada, K. Watanabe, and N. Hara. 2002. Mitochondria-mediated apoptosis of lung epithelial cells in idiopathic interstitial pneumonias. Lab. Investig. 82:1695-1706.
16. Lemjabbar, H., P. Gosset, E. Lechapt-Zalcman, M. L. Franco-Montoya, B. Wallaert, A. Harf, and C. Lafuma. 1999. Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis. Effect of steroid and immunosuppressive treatment. Am. J. Respir. Cell Mol. Biol. 20:903-913.
17. Li, Y., A. Azuma, S. Takahashi, J. Usuki, K. Matsuda, A. Aoyama, and S. Kudoh. 2002. Fourteen-membered ring macrolides inhibit vascular cell adhesion molecule 1 messenger RNA induction and leukocyte migration: role in preventing lung injury and fibrosis in bleomycin-challenged mice. Chest 122:2137-2145.
18. Nettelbladt, O., K. Lundberg, A. Tengblad, and R. Hallgren. 1990. Accumulation of hyaluronan in bronchoalveolar lavage fluid is independent of iron-, complement- and granulocyte-depletion in bleomycin-induced alveolitis in the rat. Eur. Respir. J. 3:765-771.
19. Oishi, K., F. Sonoda, S. Kobayashi, A. Iwagaki, T. Nagatake, and K. Matsushima. 1994. Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect. Immun. 62:4145-4152.
20. Owens, G. R., I. L. Paradis, S. Gryzan, T. A. Medsger, Jr., W. P. Follansbee, H. A. Klein, and J. H. Dauber. 1986. Role of inflammation in the lung disease of systemic sclerosis: comparison with idiopathic pulmonary fibrosis. J. Lab. Clin. Med. 107:253-260.
21. Piguet, P. F., M. A. Collart, G. E. Grau, Y. Kapanci, and P. Vassali. 1989. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneu-mopathy and fibrosis. J. Exp. Med. 170:655-663.
22. Shapira, L., V. Barak, W. A. Soskolne, A. Halabi, and A. Stabholz. 1998. Effects of tetracyclines on the pathologic activity of endotoxin: in vitro and in vivo studies. Adv. Dent. Res. 12:119-122.
23. Sisson, T. H., K. E. Hanson, N. Subbotina, A. Patwardhan, N. Hattori, and R. H. Simon. 2002. Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L1023-L1032.
24. Tanino, Y., H. Makita, K. Miyamoto, T. Betsuyaku, Y. Ohtsuka, J. Nishihira, and M. Nishimura. 2002. Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L156-L162.