Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 9, 2008, Pages 1630-1644

  De La Monte, Suzanne M ^a,c   Tong, Ming ^a   Cohen, Ariel C ^a   Sheedy, Donna ^b   Harper, Clive ^b   Wands, Jack R ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Acetylcholine; Alcoholic; Central nervous system; Human; Insulin resistance; Neurodegeneration; Receptor ligand binding

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ADULT; ALCOHOL ABUSE; ALCOHOLISM; ARTICLE; CEREBELLUM VERMIS; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GLIOSIS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; LONG TERM EXPOSURE; MALE; NERVE DEGENERATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ALCOHOLISM; CASE-CONTROL STUDIES; CEREBELLUM; DNA DAMAGE; GYRUS CINGULI; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; RECEPTOR, IGF TYPE 1; RECEPTOR, IGF TYPE 2; RECEPTOR, INSULIN; SOMATOMEDINS;

EPICOCCUM; RATTUS;

EID: 50849117830     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00731.x     Document Type: Article

References (54)

1. Alexander BM, Dugast I, Ercolani L, Kong XF, Giere L, Nasrin N (1992) Multiple insulin-responsive elements regulate transcription of the GAPDH gene. Adv Enzyme Regul 32 : 149 159.
2. Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 : 599 602.
3. Chu J, Tong M, de la Monte SM (2007) Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons. Acta Neuropathol (Berl) 113 : 659 673.
4. Cohen AC, Tong M, Wands JR, de la Monte SM (2007) Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin Exp Res 31 : 1558 1573.
5. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A 95 : 11211 11216.
6. Diamond I, Gordon AS (1997) Cellular and molecular neuroscience of alcoholism. Physiol Rev 77 : 1 20.
7. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt [see comments]. Science 275 : 661 665.
8. Eves EM, Xiong W, Bellacosa A, Kennedy SG, Tsichlis PN, Rosner MR, Hay N (1998) Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol 18 : 2143 2152.
9. Gammeltoft S, Fehlmann M, Van OE (1985) Insulin receptors in the mammalian central nervous system: binding characteristics and subunit structure. Biochimie 67 : 1147 1153.
10. Goodyer CG, De SL, Lai WH, Guyda HJ, Posner BI (1984) Characterization of insulin-like growth factor receptors in rat anterior pituitary, hypothalamus, and brain. Endocrinology 114 : 1187 1195.
11. Guerri C (1998) Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure. Alcohol Clin Exp Res 22 : 304 312.
12. Hallak H, Seiler AE, Green JS, Henderson A, Ross BN, Rubin R (2001) Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells. Alcohol Clin Exp Res 25 : 1058 1064.
13. Harper C (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57 : 101 110.
14. Harper C, Dixon G, Sheedy D, Garrick T (2003) Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Prog Neuropsychopharmacol Biol Psychiatry 27 : 951 961.
15. Herr F, Liang OD, Herrero J, Lang U, Preissner KT, Han VK, Zygmunt M (2003) Possible angiogenic roles of insulin-like growth factor II and its receptors in uterine vascular adaptation to pregnancy. J Clin Endocrinol Metab 88 : 4811 4817.
16. Hill JM, Lesniak MA, Pert CB, Roth J (1986) Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 17 : 1127 1138.
17. Hu JG, Fu SL, Zhang KH, Li Y, Yin L, Lu PH, Xu XM (2004) Differential gene expression in neural stem cells and oligodendrocyte precursor cells: a cDNA microarray analysis. J Neurosci Res 78 : 637 646.
18. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, Dikranian K, Olney JW (2000) Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287 : 1056 1060.
19. Ito D, Tanaka K, Suzuki S, Dembo T, Fukuuchi Y (2001) Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 32 : 1208 1215.
20. Jackson TR, Blader IJ, Hammonds OL, Burga CR, Cooke F, Hawkins PT, Wolf AG, Heldman KA, Theibert AB (1996) Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci 109(Pt 2) : 289 300.
21. Kikuchi A, Takeda A, Onodera H, Kimpara T, Hisanaga K, Sato N, Nunomura A, Castellani RJ, Perry G, Smith MA, Itoyama Y (2002) Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis 9 : 244 248.
22. Kulik G, Klippel A, Weber MJ (1997) Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17 : 1595 1606.
23. Kumagai T, Kitagawa Y, Hirose G, Sakai K (1999) Antibody recognition and RNA binding of a neuronal nuclear autoantigen associated with paraneoplastic neurological syndromes and small cell lung carcinoma. J Neuroimmunol 93 : 37 44.
24. Kurihara S, Hakuno F, Takahashi S (2000) Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway. Endocr J 47 : 739 751.
25. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL (1994) The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem 269 : 20648 20652.
26. Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM (2006) Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis 9 : 13 33.
27. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res 24 : 1873 1882.
28. Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31 : 1574 1582.
29. Markus A, Zhong J, Snider WD (2002) Raf and akt mediate distinct aspects of sensory axon growth. Neuron 35 : 65 76.
30. de la Monte SM (1988) Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch Neurol 45 : 990 992.
31. de la Monte SM, Ganju N, Banerjee K, Brown NV, Luong T, Wands JR (2000) Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase. Alcohol Clin Exp Res 24 : 716 726.
32. de la Monte SM, Jhaveri A, Maron BA, Wands JR (2007) Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery. J Neuropathol Exp Neurol 66 : 272 283.
33. de la Monte SM, Neely TR, Cannon J, Wands JR (2001) Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons. Cell Mol Life Sci 58 : 1950 1960.
34. de la Monte SM, Tong M, Lester-Coll N, Plater M Jr., Wands JR (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease. J Alzheimers Dis 10 : 89 109.
35. de la Monte SM, Wands JR (2001) Mitochondrial DNA damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells. Alcohol Clin Exp Res 25 : 898 906.
36. de la Monte SM, Wands JR (2002) Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons. Cell Mol Life Sci 59 : 882 893.
37. de la Monte SM, Wands JR (2005) Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis 7 : 45 61.
38. de la Monte SM, Wands JR (2006) Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis 9 : 167 181.
39. de la Monte SM, Xu XJ, Wands JR (2005) Ethanol inhibits insulin expression and actions in the developing brain. Cell Mol Life Sci 62 : 1131 1145.
40. Myers MG, White MF (1993) The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 42 : 643 650.
41. Patel TB (2004) Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades. Pharmacol Rev 56 : 371 385.
42. Payao SL, Smith MA, Winter LM, Bertolucci PH (1998) Ribosomal RNA in Alzheimer's disease and aging. Mech Ageing Dev 105 : 265 272.
43. Puro DG, Agardh E (1984) Insulin-mediated regulation of neuronal maturation. Science 225 : 1170 1172.
44. Ramachandran V, Perez A, Chen J, Senthil D, Schenker S, Henderson GI (2001) In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4- hydroxynonenal. Alcohol Clin Exp Res 25 : 862 871.
45. Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM (2005) Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 8 : 247 268.
46. da Silva AM, Payao SL, Borsatto B, Bertolucci PH, Smith MA (2000) Quantitative evaluation of the rRNA in Alzheimer's disease. Mech Ageing Dev 120 : 57 64.
47. Soscia SJ, Tong M, Xu XJ, Cohen AC, Chu J, Wands JR, de la Monte SM (2006) Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Cell Mol Life Sci 63 : 2039 2056.
48. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimers Dis 7 : 63 80.
49. Sun XJ, Crimmins DL, Myers MJ, Miralpeix M, White MF (1993) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13 : 7418 7428.
50. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner JB, Furneaux HM (1991) HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell 67 : 325 333.
51. Virdee K, Xue L, Hemmings BA, Goemans C, Heumann R, Tolkovsky AM (1999) Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons. Brain Res 837 : 127 142.
52. Xu J, Yeon JE, Chang H, Tison G, Chen GJ, Wands J, de la Monte S (2003) Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem 278 : 26929 26937.
53. Zhang FX, Rubin R, Rooney TA (1998) Ethanol induces apoptosis in cerebellar granule neurons by inhibiting insulin-like growth factor 1 signaling. J Neurochem 71 : 196 204.
54. Zygmunt M, McKinnon T, Herr F, Lala PK, Han VK (2005) HCG increases trophoblast migration in vitro via the insulin-like growth factor-II/mannose-6 phosphate receptor. Mol Hum Reprod 11 : 261 267.