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Volumn 71, Issue 1, 1998, Pages 196-204

Ethanol induces apoptosis in cerebellar granule neurons by inhibiting insulin-like growth factor 1 signaling

Author keywords

Apoptosis; Cerebellar granule neurons; Ethanol; Insulin like growth factor 1

Indexed keywords

ALCOHOL; SOMATOMEDIN C;

EID: 0031812482     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71010196.x     Document Type: Article
Times cited : (111)

References (50)
  • 2
    • 0023933146 scopus 로고
    • Differing expression of insulin-like growth factor I in the developing and in the adult rat cerebellum
    • Andersson I. K., Edwall D., Norstedt G., Rozell B., Skottner A., and Hansson H.-A. (1988) Differing expression of insulin-like growth factor I in the developing and in the adult rat cerebellum. Acta Physiol. Scand. 132, 167-173.
    • (1988) Acta Physiol. Scand. , vol.132 , pp. 167-173
    • Andersson, I.K.1    Edwall, D.2    Norstedt, G.3    Rozell, B.4    Skottner, A.5    Hansson, H.-A.6
  • 3
    • 0025979940 scopus 로고
    • Expression of IGF-I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis
    • Baron-Van Evercooren A., Olichon-Berthe C., Kowalski A., Visciano G., and Van Obberghen E. (1991) Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis. J. Neurosci. Res. 28, 244-253.
    • (1991) J. Neurosci. Res. , vol.28 , pp. 244-253
    • Baron-Van Evercooren, A.1    Olichon-Berthe, C.2    Kowalski, A.3    Visciano, G.4    Van Obberghen, E.5
  • 4
    • 0017338602 scopus 로고
    • The effect of ethanol chronically administered to preweanling rats on cerebellar development: A morphological study
    • Bauer-Moffett C. and Altman J. (1977) The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study. Brain Res. 119, 249-268.
    • (1977) Brain Res. , vol.119 , pp. 249-268
    • Bauer-Moffett, C.1    Altman, J.2
  • 5
    • 0031033269 scopus 로고    scopus 로고
    • Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA
    • Bhave S. V. and Huffman P. L. (1997) Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA. J. Neurochem. 68, 578-586.
    • (1997) J. Neurochem. , vol.68 , pp. 578-586
    • Bhave, S.V.1    Huffman, P.L.2
  • 6
    • 0030772513 scopus 로고    scopus 로고
    • IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner
    • Blair L. A. C. and Marshall J. (1997) IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner. Neuron 19, 421-429.
    • (1997) Neuron , vol.19 , pp. 421-429
    • Blair, L.A.C.1    Marshall, J.2
  • 7
    • 0025718514 scopus 로고
    • Transient IGF-1 gene expression during the maturation of functionally related projection neurons
    • Bondy C. A. (1991) Transient IGF-1 gene expression during the maturation of functionally related projection neurons. J. Neurosci. 11, 3442-3455.
    • (1991) J. Neurosci. , vol.11 , pp. 3442-3455
    • Bondy, C.A.1
  • 8
    • 0025779231 scopus 로고
    • Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt
    • Bonthius D. J. and West J. R. (1991) Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt. Teratology 44, 147-163.
    • (1991) Teratology , vol.44 , pp. 147-163
    • Bonthius, D.J.1    West, J.R.2
  • 9
    • 0028814675 scopus 로고
    • The developing CNS: A scenario for the action of proinsulin, insulin and insulin-like growth factors
    • De Pablo F. and De la Rosa E. J. (1995) The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends Neurosci. 18, 143-150.
    • (1995) Trends Neurosci. , vol.18 , pp. 143-150
    • De Pablo, F.1    De La Rosa, E.J.2
  • 10
    • 0030330547 scopus 로고    scopus 로고
    • The role of the insulin-like growth factors in the central nervous system
    • D'Ercole A. J., Ye P., Calikoglu A. S., and Gutierrez-Ospina G. (1996) The role of the insulin-like growth factors in the central nervous system. Mol. Neurobiol. 13, 227-255.
    • (1996) Mol. Neurobiol. , vol.13 , pp. 227-255
    • D'Ercole, A.J.1    Ye, P.2    Calikoglu, A.S.3    Gutierrez-Ospina, G.4
  • 11
    • 0027483920 scopus 로고
    • Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
    • D'Mello S. R., Galli C, Ciotti T., and Calissano P. (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90, 10989-10993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10989-10993
    • D'Mello, S.R.1    Galli, C.2    Ciotti, T.3    Calissano, P.4
  • 12
    • 0031054670 scopus 로고    scopus 로고
    • Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI3-kinase in IGF-1 signaling
    • D'Mello S. R., Borodezt K., and Soltoff S. P. (1997) Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI3-kinase in IGF-1 signaling. J. Neurosci. 17, 1548-1560.
    • (1997) J. Neurosci. , vol.17 , pp. 1548-1560
    • D'Mello, S.R.1    Borodezt, K.2    Soltoff, S.P.3
  • 13
    • 0343765729 scopus 로고    scopus 로고
    • Rediscovering an old friend, IGF-I: Potential use in the treatment of neurodegenerative diseases
    • Doré S., Kar S., and Quirion R. (1997) Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases. Trends Neurosci. 20, 326-331.
    • (1997) Trends Neurosci. , vol.20 , pp. 326-331
    • Doré, S.1    Kar, S.2    Quirion, R.3
  • 15
    • 0030907987 scopus 로고    scopus 로고
    • P13K: Downstream AKTion blocks apoptosis
    • Franke T. F., Kaplan D. R., and Cantley L. C. (1997) P13K: downstream AKTion blocks apoptosis. Cell 88, 435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 16
    • 0028924891 scopus 로고
    • Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanism of action: The involvement of intracellular calcium and RNA synthesis
    • Galli C., Meucci O., Scorziello A., Werge T. M., Calissano P., and Schettini G. (1995) Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanism of action: the involvement of intracellular calcium and RNA synthesis, J. Neurosci. 15, 1172-1179.
    • (1995) J. Neurosci. , vol.15 , pp. 1172-1179
    • Galli, C.1    Meucci, O.2    Scorziello, A.3    Werge, T.M.4    Calissano, P.5    Schettini, G.6
  • 17
    • 0023244774 scopus 로고
    • The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
    • Gallo V., Kingsbury A., Balázs R., and Jõrgensen O. S. (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
    • (1987) J. Neurosci. , vol.7 , pp. 2203-2213
    • Gallo, V.1    Kingsbury, A.2    Balázs, R.3    Jõrgensen, O.S.4
  • 18
    • 0030971576 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival
    • Gunn-Moore F. J., Williams A. G., Toms N. J., and Tavaré J. M. (1997) Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival. Biochem. J. 324, 365-369.
    • (1997) Biochem. J. , vol.324 , pp. 365-369
    • Gunn-Moore, F.J.1    Williams, A.G.2    Toms, N.J.3    Tavaré, J.M.4
  • 19
    • 0027173306 scopus 로고
    • The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles
    • Hamre K. M. and West J. R. (1993) The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles. Alcohol. Clin. Exp. Res. 17, 610-622.
    • (1993) Alcohol. Clin. Exp. Res. , vol.17 , pp. 610-622
    • Hamre, K.M.1    West, J.R.2
  • 20
    • 0030033547 scopus 로고    scopus 로고
    • The effects of insulin-like growth factor analogues on survival of cultured cerebral cortex and cerebellar granule neurons
    • Harper S. J., Macaulay A. J., Hill R. G., and Priestley T. (1996) The effects of insulin-like growth factor analogues on survival of cultured cerebral cortex and cerebellar granule neurons. Brain Res. 709, 303-310.
    • (1996) Brain Res. , vol.709 , pp. 303-310
    • Harper, S.J.1    Macaulay, A.J.2    Hill, R.G.3    Priestley, T.4
  • 21
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate Tau phosphorylation in cultured human neurons
    • Hong M. and Lee V. M.-Y. (1997) Insulin and insulin-like growth factor-1 regulate Tau phosphorylation in cultured human neurons. J. Biol. Chem. 272, 19547-19553.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.-Y.2
  • 22
    • 0029670038 scopus 로고    scopus 로고
    • Suppression of interleukin-1β-converting enzyme-mediated cell death by insulin-like growth factor
    • Jung Y.-K., Miura M., and Yuan J. (1996) Suppression of interleukin-1β-converting enzyme-mediated cell death by insulin-like growth factor. J. Biol. Chem. 271, 5112-5117.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5112-5117
    • Jung, Y.-K.1    Miura, M.2    Yuan, J.3
  • 23
    • 0027402935 scopus 로고
    • Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-1) receptor
    • Kato H., Faria T. N., Stannard B., Roberts C. T. Jr., and LeRoith D. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-1) receptor. J. Biol. Chem. 268, 2655-2661.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2655-2661
    • Kato, H.1    Faria, T.N.2    Stannard, B.3    Roberts Jr., C.T.4    Leroith, D.5
  • 25
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 26
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D., Werner H., Beitner-Johnson D., and Roberts C. T. Jr. (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16, 143-163.
    • (1995) Endocr. Rev. , vol.16 , pp. 143-163
    • Leroith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts Jr., C.T.4
  • 27
    • 0031050651 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance
    • Leventhal P. S., Shelden E. A., Kim B., and Feldman E. L. (1997) Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance. J. Biol. Chem. 272, 5214-5218.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5214-5218
    • Leventhal, P.S.1    Shelden, E.A.2    Kim, B.3    Feldman, E.L.4
  • 28
    • 0029998442 scopus 로고    scopus 로고
    • Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and neurotrophins BDNF, NT-3 and NT-4
    • Lindholm D., Carroll P., Tzimagiorgis G., and Thoenen H. (1996) Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and neurotrophins BDNF, NT-3 and NT-4. Eur. J. Neurosci. 8, 1452-1460.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1452-1460
    • Lindholm, D.1    Carroll, P.2    Tzimagiorgis, G.3    Thoenen, H.4
  • 29
    • 0022686460 scopus 로고
    • An automated colorimetric microassay for neuronotrophic factors
    • Manthorpe M., Fagnani R., Skaper S. D., and Varon S. (1986) An automated colorimetric microassay for neuronotrophic factors. Dev. Brain Res. 25, 191-198.
    • (1986) Dev. Brain Res. , vol.25 , pp. 191-198
    • Manthorpe, M.1    Fagnani, R.2    Skaper, S.D.3    Varon, S.4
  • 30
    • 0030052757 scopus 로고    scopus 로고
    • Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death
    • Matthews C. C. and Feldman E. (1996) Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death. J. Cell. Physiol. 166, 323-331.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 323-331
    • Matthews, C.C.1    Feldman, E.2
  • 31
    • 0029909560 scopus 로고    scopus 로고
    • Metabolic and genetic analyses of apoptosis in potassium/serum-dependent rat cerebeliar granule cells
    • Miller T. M. and Johnson E. M. Jr. (1996) Metabolic and genetic analyses of apoptosis in potassium/serum-dependent rat cerebeliar granule cells. J. Neurosci. 16, 7487-7495.
    • (1996) J. Neurosci. , vol.16 , pp. 7487-7495
    • Miller, T.M.1    Johnson Jr., E.M.2
  • 32
    • 0030938816 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells
    • Miller T. M., Tansey M. G., Johnson E. M. Jr., and Creedon D. J. (1997) Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells. J. Biol. Chem. 272, 9847-9853.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9847-9853
    • Miller, T.M.1    Tansey, M.G.2    Johnson Jr., E.M.3    Creedon, D.J.4
  • 33
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim R. W. (1991) Cell death during development of the nervous system. Anna. Rev. Neurosci. 14, 453-501.
    • (1991) Anna. Rev. Neurosci. , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 35
    • 0031014651 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
    • Párrizas M., Saltiel A. R., and LeRoith D. (1997) Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272, 154-161.
    • (1997) J. Biol. Chem. , vol.272 , pp. 154-161
    • Párrizas, M.1    Saltiel, A.R.2    Leroith, D.3
  • 36
    • 0027373764 scopus 로고
    • Programmed cell death and the control of cell survival: Lessons from the nervous system
    • Raff M. C., Barres B. A., Burne J. F., Coles H. S. R., Ischizaki Y., and Jacobson M. D. (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262, 695-700.
    • (1993) Science , vol.262 , pp. 695-700
    • Raff, M.C.1    Barres, B.A.2    Burne, J.F.3    Coles, H.S.R.4    Ischizaki, Y.5    Jacobson, M.D.6
  • 37
    • 0027376366 scopus 로고
    • Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and the IGF-1-mediated proliferation of 3T3 cells
    • Resnicoff M., Sell C., Ambrose D., Baserga R., and Rubin R. (1993) Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and the IGF-1-mediated proliferation of 3T3 cells. J. Biol. Chem. 268, 21777-21782.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21777-21782
    • Resnicoff, M.1    Sell, C.2    Ambrose, D.3    Baserga, R.4    Rubin, R.5
  • 38
    • 0028043870 scopus 로고
    • Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells
    • Resnicoff M., Rubini M., Baserga R., and Rubin R. (1994) Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells. Lab. Invest. 71, 657-662.
    • (1994) Lab. Invest. , vol.71 , pp. 657-662
    • Resnicoff, M.1    Rubini, M.2    Baserga, R.3    Rubin, R.4
  • 40
    • 0029954311 scopus 로고    scopus 로고
    • Potassium deprivation-induced apoptosis of cerebellar granule neurons: A sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
    • Schultz J. B., Weller M., and Klockgether T. (1996) Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J. Neurosci. 16, 4696-4706.
    • (1996) J. Neurosci. , vol.16 , pp. 4696-4706
    • Schultz, J.B.1    Weller, M.2    Klockgether, T.3
  • 41
    • 0028238794 scopus 로고
    • Insulin-like growth factor-I induces a rapid increase in calcium currents and spontaneous membrane activity in clonal pituitary cells
    • Selinfreund R. H. and Blair L. A. C. (1994) Insulin-like growth factor-I induces a rapid increase in calcium currents and spontaneous membrane activity in clonal pituitary cells. Mol. Pharmacol. 45, 1215-1220.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 1215-1220
    • Selinfreund, R.H.1    Blair, L.A.C.2
  • 42
    • 0029738916 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis
    • Singleton J. R., Randolph A. E., and Feldman E. L. (1996a) Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis. Cancer Res. 56, 4522-4529.
    • (1996) Cancer Res. , vol.56 , pp. 4522-4529
    • Singleton, J.R.1    Randolph, A.E.2    Feldman, E.L.3
  • 43
    • 0029778530 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor activation regulates apoptotic proteins
    • Singleton J. R., Dixit V. M., and Feldman E. L. (1996b) Type I insulin-like growth factor receptor activation regulates apoptotic proteins. J. Biol. Chem. 271, 31791-31794.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31791-31794
    • Singleton, J.R.1    Dixit, V.M.2    Feldman, E.L.3
  • 44
    • 0030924231 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats
    • Tagami M., Ikeda K., Nara Y., Fujino H., Kubota A., Numano F., and Yamori Y. (1997a) Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats. Lab. Invest. 76, 613-617.
    • (1997) Lab. Invest. , vol.76 , pp. 613-617
    • Tagami, M.1    Ikeda, K.2    Nara, Y.3    Fujino, H.4    Kubota, A.5    Numano, F.6    Yamori, Y.7
  • 45
    • 0030922613 scopus 로고    scopus 로고
    • Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats
    • Tagami M., Yamagata K., Nara Y., Fujino H., Kubota A., Numano F., and Yamori Y. (1997b) Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Lab. Invest. 76, 603-612.
    • (1997) Lab. Invest. , vol.76 , pp. 603-612
    • Tagami, M.1    Yamagata, K.2    Nara, Y.3    Fujino, H.4    Kubota, A.5    Numano, F.6    Yamori, Y.7
  • 46
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos C. J., Matter W. F., Hui K. Y., and Brown R. F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 47
    • 0029005919 scopus 로고
    • Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells
    • Wegelius K. and Korpi E. R. (1995) Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells. Acta Physiol. Scand. 154, 25-34.
    • (1995) Acta Physiol. Scand. , vol.154 , pp. 25-34
    • Wegelius, K.1    Korpi, E.R.2
  • 48
    • 0030272687 scopus 로고    scopus 로고
    • Diverse molecular provocation of programmed cell death
    • Wertz I. E. and Hanley M. R. (1996) Diverse molecular provocation of programmed cell death. Trends Biol. Sci. 21, 359-364.
    • (1996) Trends Biol. Sci. , vol.21 , pp. 359-364
    • Wertz, I.E.1    Hanley, M.R.2
  • 49
    • 0029744687 scopus 로고    scopus 로고
    • Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death
    • Wu Y., Tewari M., Cui S., and Rubin R. (1996) Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death. J. Cell. Physiol. 168, 499-509.
    • (1996) J. Cell. Physiol. , vol.168 , pp. 499-509
    • Wu, Y.1    Tewari, M.2    Cui, S.3    Rubin, R.4
  • 50
    • 0028133050 scopus 로고
    • Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons
    • Yan G.-M., Ni B., Weller M., Wood K. A., and Paul S. M. (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656, 43-51.
    • (1994) Brain Res. , vol.656 , pp. 43-51
    • Yan, G.-M.1    Ni, B.2    Weller, M.3    Wood, K.A.4    Paul, S.M.5


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