Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers

Heart Rhythm

Volumn 5, Issue 9, 2008, Pages 1310-1317

  Lieu, Deborah K ^a,b,c   Chan, Yau Chi ^d   Lau, Chu Pak ^d   Tse, Hung Fat ^d   Siu, Chung Wah ^a,b,d   Li, Ronald A ^a,b,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NSF Center for Biophotonics Science and Technology   (United States)

^d Department of Medicine   (Hong Kong)

^e SHRINERS HOSPITALS FOR CHILDREN NORTHERN CALIFORNIA   (United States)

Author keywords

Gene transfer; HCN channel; Pacemaker

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE MODULATED CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; ION CHANNEL; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL HEART PACEMAKER; BIOARTIFICIAL ORGAN; CHANNEL GATING; CONTROLLED STUDY; DIASTOLE; ELECTROSTIMULATION; FEMALE; GENE DELETION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSDUCTION; GUINEA PIG; HEART ATRIUM; HEART AUTOMATICITY; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART VENTRICLE; MATHEMATICAL MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE ENGINEERING;

ACTION POTENTIALS; ANIMALS; ATRIAL FUNCTION; CARDIAC PACING, ARTIFICIAL; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; GENE TRANSFER TECHNIQUES; GUINEA PIGS; HEART ATRIA; HEART VENTRICLES; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; PACEMAKER, ARTIFICIAL; POTASSIUM CHANNELS; TISSUE ENGINEERING; UP-REGULATION; VENTRICULAR FUNCTION;

EID: 50849099151     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2008.05.010     Document Type: Article

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