Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase: Engineering effective butyrylcholinesterase mutants for cocaine detoxication

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 9330-9336

  Sun, Hong ^a   El Yazal, Jamal ^a   Lockridge, Oksana ^c   Schopfer, Lawrence M ^c   Brimijoin, Stephen ^a   Pang, Yuan Ping ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC CANCER CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CATALYSIS; COMPLEXATION; DETOXIFICATION; HYDROLYSIS; MUTAGENESIS; PH EFFECTS;

CATALYTIC SITES;

BIOCHEMISTRY;

BENZOIC ACID DERIVATIVE; CHOLINESTERASE; COCAINE; ESTER DERIVATIVE; LIGAND; MUTANT PROTEIN; PHENYL GROUP; PHENYLALANINE; SERINE; TRYPTOPHAN;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; COCAINE DEPENDENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG DETOXIFICATION; DRUG HYDROLYSIS; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME MECHANISM; ENZYME STRUCTURE; MICHAELIS MENTEN KINETICS; MOLECULAR INTERACTION; MOLECULAR MODEL; PH; PRIORITY JOURNAL; ROTATION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; HYDROLYSIS; METABOLISM; MUTATION; PROTEIN CONFORMATION;

BUTYRYLCHOLINESTERASE; COCAINE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PROTEIN CONFORMATION;

EID: 0035937713     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006676200     Document Type: Article

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