Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases

Molecular Pharmacology

Volumn 53, Issue 1, 1998, Pages 112-122

  Saxena, Ashima ^a   Ashani, Yacov ^b   Raveh, Lily ^b   Stevenson, David ^c   Patel, Thakor ^c   Doctor, B P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^c Oxford GlycoSciences   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ASPARAGINE LINKED OLIGOSACCHARIDE; CARBOHYDRATE; CHOLINESTERASE; GALACTOSE; GLYCAN DERIVATIVE; OLIGOSACCHARIDE; RECOMBINANT ENZYME; SIALIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; ENZYME GLYCOSYLATION; ENZYME METABOLISM; FETAL CALF SERUM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031890563     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.1.112     Document Type: Article

References (40)

1. Ashani Y, Shapira S, Levy D, Wolfe AD, Doctor BP, and Raveh L (1991) Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice. Biochem Pharmacol 41:37-41.
2. Ashwell G and Harford J (1982) Carbohydrate-specific receptors of the liver, Annu Rev Biochem 51:531-554.
3. Ashwell G and Morell AG (1974) The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adu Enzymol 41:99-128.
4. Bigge JC, Patel TP, Bruce JA, Goulding PN, Charles SM, and Parekh RB (1995) Non-selective and efficient fluorescent labeling of glycans using 2-amino benzamide and anthranilic acid. Anal Biochem 230:229-238.
5. Bon S, Bader M-F, Aunis D, Massoulié J, and Henry J-P (1990) Subcellular distribution of acetylcholinesterase forms in chromaffin cells. Eur J Biochem 190:221-232.
6. Brandeis R, Raveh L, Grunwald J, Cohen E, and Ashani Y (1993) Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats. Pharmacol Biochem Behav 46:889-896.
7. Broomfield CA, Maxwell DM, Solana RP, Castro CA, Finger AV, and Lenz DE (1991) Protection by butyrylcholinesterase against organophosphorus poisoning in non-human primates. J Pharmacol Exp Ther 259:633-638.
8. Chaplin MF (1982) A rapid and sensitive method for the analysis of carbohydrate components in glycoproteins using gas-liquid chromatography. Anal Biochem 123: 336-341.
9. Day JF, Thornburg RW, Thorpe SR, and Baynes JW (1980) Carbohydrate-mediated clearance of antibody antigen complexes from the circulation. J Biol Chem 255: 2360-2365.
10. De La Hoz D, Doctor BP, Ralston JS, Rush RS, and Wolfe AD (1986) A simplified procedure for the purification of large quantities of mammalian acetylcholinesterase. Life Sci 39:195-199.
11. Doctor BP, Chapman TC, Christner CE, Deal CC, De La Hoz D, Gentry MK, Ogert RA, Rush RS, Smyth KK, and Wolfe AD (1990) Complete amino acid sequence of fetal bovine serum acetylcholinesterase and its comparison in various regions with other cholinesterases. FEBS Lett 266:123-127.
12. Doctor BP, Toker L, Roth E, and Silman I (1987) Microtiter assay for acetylcholinesterase. Anal Biochem 166:399-403.
13. Douchet J-Ch, Masson P, and Morélis P (1982) Elimination de la cholinestérase plasmatique humaine purifiée injectée au rat. Sci Works 3:342-347.
14. Ellman GL, Courtney KD, Andres V Jr, and Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95.
15. Gauny SS, Andya J, Thomson J, Young JD, and Winklehake JL (1991) Effect of production method on the systemic clearance rate of a human monoclonal antibody in the rat. Hum Antibod Hybridomas 2:33-38.
16. Gibaldi M and Ferner D (1982) Pharmacokinetics. Marcel Dekker Inc., New York.
17. Goochee CF(1992) Bioprocess factors affecting glycoprotein oligosaccharide structure. Dev Biol Standard 76:95-104.
18. Heider H, Meyer P, Liao J, Stieger S, and Brodbeck U (1991) Studies on the tetrameric amphiphilic acetylcholinesterase from bovine caudate nucleus: hydrophobic domains, membrane anchoring, and state of glycosylation, in Cholinesterases: Structure, Function, Mechanism, Genetics and Cell Biology (Massoulié J, Bacou F, Barnard EA, Doctor BP, and Quinn DM, eds) pp 32-36, American Chemical Society, Washington, D. C.
19. Kronman C, Velan B, Marcus D, Ordentlich A, Reuveny S, and Shafferman A (1995) Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation. Biochem J 311:959-967.
20. Laub PB and Gallo JM (1996) N-COMP: A Windows-based program for noncompartmental analysis of pharmacokinetic data. J Pharm Sci 85:393-395.
21. Lehrman MA, Pizzo SV, Imber MJ, and Hill RL (1986) The binding of fucose-containing glycoproteins by hepatic lectins. J Biol Chem 261:7412-7418.
22. Liao J, Heider H, Sun MC, and Brodbeck U (1992) Different glycosylation in acetylcholinesterases from mammalian brain and erythrocytes. J Neurochem 58:1230-1238.
23. Liao J, Norgaard-Pedersen B, and Brodbeck U (1993) Subunit association and glycosylation of acetylcholinesterase from monkey brain. J Neurochem 61:1127-1134.
24. Lockridge O, Bartels CF, Vaughan TA, Wong CK, Norton SE, and Johnson LL (1987) Complete amino acid sequence of human serum cholinesterase. J Biol Chem 262:549-557 .
25. Lockridge O (1990) Genetic variants of human serum cholinesterase influence metabolism of muscle relaxant succinylcholine. Pharmacol Ther 47:35-60.
26. Maiorella BL, Winklehake J, Young J, Moyer B, Bauer K, Hora M, Andya J, Thomson J, Patel T, and Parekh R (1993) Effect of culture conditions on IgM antibody structure, pharmacokinetics and activity. Biotechnology 11:387-392.
27. Mattes C, Bradely R, Slaughter E, and Browne S (1996) Cocaine and butyrylcholinesterase determination of enzymatic parameters. Life Sci 58:257-261.
28. Maxwell DM, Castro CA, De La Hoz DM, Gentry MK, Gold MB, Solana RP, Wolfe AD, and Doctor BP (1992) Protection of rhesus monkeys against soman and prevention of performance decrement by pretreatment with acetylcholinesterase. Toxicol Appl Pharmacol 115:44-49.
29. Ohkura T, Hada T, Higashino K, Ohue T, Kochibe N, and Yamashita K (1994) Increase of fucosylated serum cholinesterase in relation to high risk groups for hepatocellular carcinomas. Cancer Res 54:55-61.
30. Parekh RB, Dwek RA, Rudd PM, Thomas JR, and Rademacher TW (1989) N-glycosylation and in vitro enzymatic activity of human recombinant tissue plasminogen activator expressed in Chinese hamster ovary cells and a murine cell line. Biochemistry 28:7670-7679.
31. Rachinsky TL, Camp S, Li Y, Ekstrom TJ, Newton M, and Taylor P (1990) Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Neuron 5:317-327.
32. Raveh L, Ashani Y, Levy D, De La Hoz DM, Wolfe AD, and Doctor BP (1989) Acetylcholinesterase prophylaxis against organophosphate poisoning: quantitative correlation between protection and blood enzyme level in mice. Biochem Pharmacol 38:529-534.
33. Raveh L, Grauer E, Grunwald J, Cohen E, and Ashani Y (1997) The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase. Toxicol Appl Pharmacol 145:43-53.
34. Raveh L, Grunwald J, Marcus D, Papier Y, Cohen E, and Ashani Y (1993) Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity, in vitro and in vivo quantitative characterization. Biochem Pharmacol 45:2465-2474.
35. Rudd PM, Morgan BP, Wormald MR, Harvey DJ, van den Berg CW, Davis SJ, Ferguson MAJ, and Dwek RA (1997) The glycosylation of complement regulatory protein, human erythrocyte CD59. J Biol Chem 272:7229-7244.
36. Saxena A, Raveh L, Ashani Y, and Doctor BP (1997) Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase. Biochemistry 36: 7481-7489.
37. Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedman T, and Taylor P (1986) Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature (Lond) 319:407-409.
38. Scott LJ and Sanes JR (1984) A lectin that selectively stains neuromuscular junctions binds to collagen-tailed acetylcholinesterase. Neurosci Abstr 10:546.
39. Takeuchi M, Inoue N, Strickland TW, Kubota M, Wada M, Shimizu R, Hoshi S, Kozutsumi H, Takasaki S, and Kobata A (1989) Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells. Proc Natl Acad Sci USA 86:7819-7822.
40. Wolfe AD, Blick DW, Murphy MR, Miller SA, Gentry MK, Hartgraves SL, and Doctor BP (1992) Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity. Toxicol Appl Pharmacol 117:189-193.