Anesthetics provide limited but real protection against acute brain injury

Journal of Neurosurgical Anesthesiology

Volumn 16, Issue 4, 2004, Pages 303-307

  Warner, David S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; HALOTHANE; ISOFLURANE; LIDOCAINE; PROPOFOL; THIOPENTAL;

BRAIN INJURY; BRAIN ISCHEMIA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY; TREATMENT OUTCOME;

ACUTE DISEASE; ANESTHETICS; ANIMALS; BRAIN INJURIES; HUMANS; NEUROPROTECTIVE AGENTS; SPINAL CORD INJURIES;

EID: 5044236650     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008506-200410000-00011     Document Type: Review

References (65)

1. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-556.
2. Roberts I, Schierhout G, Alderson P. Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury - a systematic review. J Neurol Neurosurg Psychiat. 1998;65:729-733.
3. Popovic R, Liniger R, Bickler PE. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. Anesthesiology. 2000;92:1343-1349.
4. Sullivan BL, Leu D, Taylor DM, et al. Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. Anesthesiology. 2002;96:189-195.
5. Kudo M, Aono M, Lee Y, et al. Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal/glial cultures. Anesthesiology. 2001;95:756-765.
6. Amorim P, Chambers G, Cottrell J, et al. Propofol reduces neuronal transmission damage and attenuates the changes in calcium, potassium, and sodium during hyperthermic anoxia in the rat hippocampal slice. Anesthesiology. 1995;83:1254-1265.
7. Wise-Faberowski L, Raizada MK, Sumners C. Oxygen and glucose deprivation-induced neuronal apoptosis is attenuated by halothane and isoflurane. Anesth Analg. 2001;93:1281-1287.
8. Wise-Faberowski L, Aono M, Pearlstein RD, et al. Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against NMDA excitotoxicity. Anesth Analg. (in press).
9. Yang J, Zorumski CF. Effects of isoflurane on N-methyl-D-aspartate gated ion channels in cultured rat hippocampal neurons. Ann NY Acad Sci. 1991;625:287-289.
10. Bickler PE, Buck LT, Hansen BM. Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Anesthesiology. 1994;81:1461-1469.
11. Harada H, Kelly PJ, Cole DJ, et al. Isoflurane reduces N-methyl-D-aspartate toxicity in vivo in the rat cerebral cortex. Anesth Analg. 1999;89:1442-1447.
12. Jenkins A, Greenblatt EP, Faulkner HJ, et al. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. J Neurosci. 2001;21:RC136.
13. Harris BD, Moody EJ, Basile AS, et al. Volatile anesthetics bidirectionally and stereospecifically modulate ligand binding to GABA receptors. Eur J Pharmacol. 1994;267:269-274.
14. A-benzodiazepine receptor binding by isoflurane. Anesthesiology. 2001;95:585-593.
15. A neurotransmission and cerebral ischemia. J Neurochem. 2001;77:353-371.
16. Davies LM, MacLellan CL, Corbett DR, et al. Post-ischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection after forebrain ischemia in gerbils. Brain Res. 2004;1013:223-229.
17. Bickler PE, Warner DS, Stratmann G, et al. gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Anesth Analg. 2003;97:564-571.
18. Costa C, Leone G, Saulle E, et al. Coactivation of GABAA and GABAB receptor results in neuroprotection during in vitro ischemia. Stroke. 2004; 35:596-600.
19. Sugimura M, Kitayama S, Morita K, et al. Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice. Pharmacol Biochem Behav. 2002;72:111-116.
20. B receptors in are CA1 of rat hippocampus. Br J Anaesth. 1997;78:60-65.
21. Kudo M, Aono M, Lee Y, et al. Absence of direct anti-oxidant effects from volatile anesthetics in primary mixed neuronal/glial cultures. Anesthesiology. 2001;94:303-312.
22. Wilson JX, Gelb AW. Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics. J Neurosurg Anesthesiol. 2002;14:66-79.
23. Patel P, Drummond JC, Cole DJ, et al. Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats. Anesth Analg. 1998;86:773-780.
24. Ochiai C, Asano T, Takakura K, et al. Mechanisms of cerebral protection by pentobarbital and nizofenone correlated with the course of local cerebral blood flow changes. Stroke. 1982;13:788-795.
25. Warner DS, Hansen TD, Vust L, et al. The effects of isoflurane and pentobarbital on the distribution of cerebral blood flow during focal cerebral ischemia in the rat. J Neurosurg Anesth. 1989;1:219-226.
26. Kahraman S, Demiryürek AT. Propofol is a peroxynitrite scavenger. Anesth Analg. 1997;84:1127-1129.
27. Todd MM, Warner DS. A comfortable hypothesis reevaluated-Cerebral metabolic depression and brain protection during ischemia (editorial). Anesthesiology. 1992;76:161-164.
28. Verhaegen M, Todd MM, Warner DS. Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia - An examination of cerebral blood flow thresholds and times to depolarization. Anesthesiology. 1994;81:965-973.
29. Harris RJ, Symon L. Extracellular pH, potassium, and calcium activities in progressive ischaemia of rat cortex. J Cereb Blood Flow Metab. 1984; 4:178-186.
30. Nellgard B, Mackensen GB, Pineda J, et al. Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 2000;93:431-436.
31. Michenfelder JD, Sundt TM, Fode N, et al. Isoflurane when compared to enflurane and halothane decreases the frequency of cerebral ischemia during carotid endarterectomy. Anesthesiology. 1987;67:336-340.
32. Bhardwaj A, Castro IA, Alkayed NJ, et al. Anesthetic choice of halothane versus propofol: impact on experimental perioperative stroke. Stroke. 2001;32:1920-1925.
33. Kapinya KJ, Lowl D, Futterer C, et al. Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke. 2002;33:1889-1898.
34. Zheng S, Zuo Z. Isoflurane preconditioning reduces Purkinje cell death in an in vitro model of rat cerebellar ischemia. Neuroscience. 2003;118:99-106.
35. Homi HM, Mixco JM, Sheng H, et al. Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice. Anesthesiology. 2003;99:1145-1151.
36. Soonthon-Brant V, Patel P, Drummond JC, et al. Fentanyl does not increase brain injury after focal cerebral ischemia in rats. Anesth Analg. 1999;88:49-55.
37. Warner DS, McFarlane C, Todd MM, et al. Sevoflurane and halothane reduce focal ischemic brain damage in the rat: Possible influence on thermoregulation. Anesthesiology. 1993;79:985-992.
38. Saito R, Graf R, Hubel K, et al. Reduction of infarct volume by halothane: Effect on cerebral blood flow or perifocal spreading depression-like depolarizations. J Cereb Blood Flow Metab. 1997;17:857-864.
39. Blanck TJ, Haile M, Xu F, et al. Isoflurane pretreatment ameliorates post-ischemic neurologic dysfunction and preserves hippocampal Ca2+ /Calmodulin-dependent protein kinase in a canine cardiac arrest model. Anesthesiology. 2000;93:1285-1293.
40. Kurth CD, Priestley M, Watzman HM, et al. Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs. Anesthesiology. 2001;95:959-964.
41. Cole DJ, Shapiro HM, Drummond JC, et al. Halothane, fentanyl/nitrous oxide, and spinal lidocaine protect against spinal cord injury in the rat. Anesthesiology. 1989;70:967-972.
42. Oldfield E, Friedman R, Kinsella T, et al. Reduction in radiation-induced brain injury by use of pentobarbital or lidocaine protection. J Neurosurg. 1990;72:737-744.
43. Statler KD, Kochanek PM, Dixon CE, et al. Isoflurane improves long-term neurologic outcome vs. fentanyl after traumatic brain injury in rats. J Neurotrauma. 2000;17:1179-1190.
44. Statler KD, Janesko KL, Melick JA, et al. Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. Brain Res. 2003;994:37-43.
45. Warner DS, Ludwig PS, Pearlstein R, et al. Halothane reduces focal ischemic injury in the rat when brain temperature is controlled. Anesthesiology. 1995;82:1237-1245.
46. Sarraf-Yazdi S, Sheng H, Brinkhous A, et al. Effects of post-ischemic halothane administration on outcome from focal cerebral ischemia in the rat. J Neurosurg Anesth. 1999;11:31-36.
47. Brain Resuscitation Clinical I Study Group. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med. 1986;314:397-441.
48. Eisenberg HM, Frankowski RF, Contant CF, et al. High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg. 1988;69:15-23.
49. Ward JD, Becker DP, Miller JD, et al. Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg. 1985;62:383-388.
50. Zaidan J, Klochany A, Martin W, et al. Effect of thiopental on neurologic outcome following coronary artery bypass grafting. Anesthesiology. 1991;74:406-411.
51. Roach GW, Newman MF, Murkin JM, et al. Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Anesthesiology. 1999;90:1255-1264.
52. Mitchell SJ, Pellett O, Gorman DF. Cerebral protection by lidocaine during cardiac operations. Ann Thorac Surg. 1999;67:1117-1124.
53. Wang D, Wu X, Li J, et al. The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery. Anesth Analg. 2002;95:1134-1141.
54. Nussmeier NA, Arlund C, Slogoff S. Neuropsychiatric complications after cardiopulmonary bypass: Cerebral protection by a barbiturate. Anesthesiology. 1986;64:165-170.
55. Grigore AM, Mathew J, Grocott HP, et al. Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery. Anesthesiology. 2001; 95:1110-1119.
56. Larsen S, Zaric D, Boysen G. Postoperative cerebrovascular accidents in general surgery. Acta Anaesth Scand. 1988;32:698-701.
57. Warner DS. Perioperative neuroprotection: Are we asking the right questions. Anesth Analg. 2004;98:563-565.
58. Dietrich WD, Busto R, Alonso O, et al. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metabol. 1993;13:541-549.
59. Block F, Bozdag I, Nolden-Koch M. Inflammation contributes to postponed neuronal damage following treatment with a glutamate antagonist in rats. Neurosci Lett. 2001;298:103-106.
60. Valtysson J, Hillered L, Andine P, et al. Neuropathologic endpoints in experimental pharmacotherapy: the importance of both early and late evaluation. Acta Neurochir (Wien). 1994;129:58-63.
61. Colbourne F, Li H, Buchan AM. Continuing postischemic neuronal death in CA1 - Influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats. Stroke. 1999;30:662-667.
62. Kawaguchi M, Kimbro JR, Drummond JC, et al. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. Anesthesiology. 2000;92:1335-1342.
63. Kawaguchi M, Drummond JC, Cole DJ, et al. Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth Analg. 2004;98:798-805.
64. Inoue S, Drummond JC, Davis DP, et al. Combination of isoflurane and caspase inhibition reduces cerebral injury in rats subjected to focal cerebral ischemia. Anesthesiology. 2004;101:75-81.
65. Lei B, Popp S, Capuano-Waters C, et al. Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats. Neuroscience. 2004;125:691-701.