Propofol is a peroxynitrite scavenger

Anesthesia and Analgesia

Volumn 84, Issue 5, 1997, Pages 1127-1129

  Kahraman, Sibel ^b   Demiryürek, Abdullah T ^a  

^a GAZI UNIVERSITY   (Turkey)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITROGEN DIOXIDE; PROPOFOL; REACTIVE OXYGEN METABOLITE;

ANESTHESIA INDUCTION; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN SYNAPTOSOME; CHEMOLUMINESCENCE; ENDOTHELIUM CELL; GENERAL ANESTHESIA; LIPID PEROXIDATION; LUNG INJURY; PRIORITY JOURNAL; SCAVENGING SYSTEM;

EID: 0342618486     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199705000-00032     Document Type: Article

References (17)

1. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-4.
2. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 1995;268:L699-722.
3. Bryson HM, Fulton BR, Faulds D. Propofol: an update of its use in anaesthesia and conscious sedation. Drugs 1995;50:513-59.
4. Aarts L, van der Hee R, Dekker I, et al. The widely used anesthetic agent propofol can replace α-tocopherol as an anti-oxidant. FEBS Lett 1995;357:83-5.
5. Murphy PG, Bennett JR, Myers DS, et al. The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes. Eur J Anaesth 1993;10:261-6.
6. Musacchio E, Rizzoli V, Bianchi M, et al. Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat. Pharmacol Toxicol 1991;69:75-7.
7. Green TR, Bennett SR, Nelson VM. Specificity and properties of propofol as an antioxidant free radical scavenger. Toxicol Appl Pharmacol 1994;129:163-9.
8. Demiryürek AT, Wainwright CL, Wadsworth RM, Kane KA. Characterization of a method for the detection of drugs with free radical scavenging activity using porcine leukocytes. J Pharmacol Toxicol Methods 1994;32:35-40.
9. 2 species in vitro and in rat lungs by chemiluminescence. J Appl Physiol 1989;67:1912-21.
10. Beckman JS, Chen J, Ischiropoulos H, Crow JP. Oxidative chemistry of peroxynitrite. In: Packer L, ed. Oxygen radicals in biological systems. Part C. Methods in enzymology. San Diego: Academic Press, 1994:229-40.
11. Radi R, Cosgrove TP, Beckman JS, Freeman BA. Peroxynitrite-induced luminol chemiluminescence. Biochem J 1993;290:51-7.
12. Kooy NW, Royall JA. Agonist-induced peroxynitrite production from endothelial cells. Arch Biochem Biophys 1994;310:352-9.
13. Kanto J, Gepts E. Pharmacokinetic implications for the clinical use of propofol. Clin Pharmacokinet 1989;17:308-26.
14. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 1991;288: 481-7.
15. Krumholz W, Endrass J, Hempelmann G. Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro. Can J Anaesth 1994;41:446-9.
16. Zhu L, Gunn C, Beckman JS. Bactericidal activity of peroxynitrite. Arch Biochem Biophys 1992;298:452-7.
17. Kooy NW, Royall JA, Ye YZ, et al. Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 1995;151:1250-4.