Use of human tissue in ADME and safety profiling of development candidates

Drug Discovery Today

Volumn 6, Issue 21, 2001, Pages 1116-1126

  Coleman, Robert A ^a   Bowen, Wayne P ^a   Baines, Ian A ^a   Woodrooffe, Amanda J ^a   Brown, Anthony M ^a  

^a Pharmagene Laboratories   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CARBON MONOXIDE; CARBON TETRACHLORIDE; CHLOROFORM; CYTOCHROME P450; DICHLOROMETHANE; DRUG METABOLIZING ENZYME; FLUOROCITRIC ACID; GALACTOSAMINE; GLYCOPROTEIN P; LANSOPRAZOLE; MACROGOL 400; MENADIONE; MUSCARINIC AGENT; OMEPRAZOLE; PANADIPLON; PARACETAMOL; PROPRANOLOL DERIVATIVE; RIFAMPICIN; ROSIGLITAZONE; SUMATRIPTAN; SUPEROXIDE; TROGLITAZONE; XENOBIOTIC AGENT;

CATARACT; CATARACTOGENESIS; CELL LINE; CYTOTOXICITY; DONOR; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DRUG UPTAKE; ENZYME INDUCTION; EXPERIMENTAL MODEL; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL TRACT; HUMAN; LIVER CELL; LIVER METABOLISM; MIGRAINE; NONHUMAN; REVIEW; RISK ASSESSMENT; THORAX PAIN; TOXICITY; XENOBIOTIC METABOLISM;

EID: 0035499939     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01977-8     Document Type: Review

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