메뉴 건너뛰기




Volumn 446, Issue , 2008, Pages 189-204

Chapter 11 Purification and Bioassay of Hedgehog Ligands for the Study of Cell Death and Survival

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; CHOLESTEROL; HYBRID PROTEIN; ISOLEUCINE; LIGAND; PALMITIC ACID; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN;

EID: 50349087678     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)01611-X     Document Type: Review
Times cited : (13)

References (49)
  • 1
    • 0033581876 scopus 로고    scopus 로고
    • Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
    • Ahlgren S.C., and Bronner-Fraser M. Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death. Curr. Biol. 9 (1999) 1304-1314
    • (1999) Curr. Biol. , vol.9 , pp. 1304-1314
    • Ahlgren, S.C.1    Bronner-Fraser, M.2
  • 3
    • 33847009559 scopus 로고    scopus 로고
    • Hedgehog signaling promotes medulloblastoma survival via BclII
    • Bar E.E., Chaudhry A., Farah M.H., and Eberhart C.G. Hedgehog signaling promotes medulloblastoma survival via BclII. Am. J. Pathol. 170 (2007) 347-355
    • (2007) Am. J. Pathol. , vol.170 , pp. 347-355
    • Bar, E.E.1    Chaudhry, A.2    Farah, M.H.3    Eberhart, C.G.4
  • 4
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy P.A., Karhadkar S.S., and Berman D.M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432 (2004) 324-331
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 6
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood M.J., and McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172 (1995) 126-138
    • (1995) Dev. Biol. , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 9
    • 0034752055 scopus 로고    scopus 로고
    • Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis
    • Charrier J.B., Lapointe F., Le Douarin N.M., and Teillet M.A. Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis. Development 128 (2001) 4011-4020
    • (2001) Development , vol.128 , pp. 4011-4020
    • Charrier, J.B.1    Lapointe, F.2    Le Douarin, N.M.3    Teillet, M.A.4
  • 10
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    • Chen M.H., Li Y.J., Kawakami T., Xu S.M., and Chuang P.T. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18 (2004) 641-659
    • (2004) Genes Dev. , vol.18 , pp. 641-659
    • Chen, M.H.1    Li, Y.J.2    Kawakami, T.3    Xu, S.M.4    Chuang, P.T.5
  • 11
    • 33751337806 scopus 로고    scopus 로고
    • Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis
    • Chen X., Horiuchi A., Kikuchi N., Osada R., Yoshida J., Shiozawa T., and Konishi I. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis. Cancer Sci. 98 (2007) 68-76
    • (2007) Cancer Sci. , vol.98 , pp. 68-76
    • Chen, X.1    Horiuchi, A.2    Kikuchi, N.3    Osada, R.4    Yoshida, J.5    Shiozawa, T.6    Konishi, I.7
  • 12
  • 13
    • 16844370419 scopus 로고    scopus 로고
    • Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
    • Colnot C., de la Fuente L., Huang S., Hu D., Lu C., St-Jacques B., and Helms J.A. Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132 (2005) 1057-1067
    • (2005) Development , vol.132 , pp. 1057-1067
    • Colnot, C.1    de la Fuente, L.2    Huang, S.3    Hu, D.4    Lu, C.5    St-Jacques, B.6    Helms, J.A.7
  • 16
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., and McMahon A.P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75 (1993) 1417-1430
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 17
    • 0041731665 scopus 로고    scopus 로고
    • Longing for ligand: Hedgehog, patched, and cell death
    • Guerrero I., and Ruiz i Altaba A. Longing for ligand: Hedgehog, patched, and cell death. Science 301 (2003) 774-776
    • (2003) Science , vol.301 , pp. 774-776
    • Guerrero, I.1    Ruiz i Altaba, A.2
  • 18
    • 0012466695 scopus 로고    scopus 로고
    • Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
    • Guy R.K. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc. Natl. Acad. Sci. USA 97 (2000) 7307-7312
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7307-7312
    • Guy, R.K.1
  • 19
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • Harfe B.D., Scherz P.J., Nissim S., Tian H., McMahon A.P., and Tabin C.J. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118 (2004) 517-528
    • (2004) Cell , vol.118 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 20
    • 19944429892 scopus 로고    scopus 로고
    • Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: Conditional skin tumorigenesis recapitulates the hair growth cycle
    • Hutchin M.E., Kariapper M.S., Grachtchouk M., Wang A., Wei L., Cummings D., Liu J., Michael L.E., Glick A., and Dlugosz A.A. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: Conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 19 (2005) 214-223
    • (2005) Genes Dev. , vol.19 , pp. 214-223
    • Hutchin, M.E.1    Kariapper, M.S.2    Grachtchouk, M.3    Wang, A.4    Wei, L.5    Cummings, D.6    Liu, J.7    Michael, L.E.8    Glick, A.9    Dlugosz, A.A.10
  • 21
    • 38049115661 scopus 로고    scopus 로고
    • PKA, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells
    • Ji Z., Mei F.C., Johnson B.H., Thompson E.B., and Cheng X. PKA, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells. J. Biol. Chem. Epub Sept 25 (2007)
    • (2007) J. Biol. Chem. Epub Sept , vol.25
    • Ji, Z.1    Mei, F.C.2    Johnson, B.H.3    Thompson, E.B.4    Cheng, X.5
  • 23
    • 33646247878 scopus 로고    scopus 로고
    • Cholesterol modification restricts the spread of Shh gradient in the limb bud
    • Li Y., Zhang H., Litingtung Y., and Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl. Acad. Sci. USA 103 (2006) 6548-6553
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6548-6553
    • Li, Y.1    Zhang, H.2    Litingtung, Y.3    Chiang, C.4
  • 24
    • 33645085841 scopus 로고    scopus 로고
    • AlphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
    • Lien W.H., Klezovitch O., Fernandez T.E., Delrow J., and Vasioukhin V. AlphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311 (2006) 1609-1612
    • (2006) Science , vol.311 , pp. 1609-1612
    • Lien, W.H.1    Klezovitch, O.2    Fernandez, T.E.3    Delrow, J.4    Vasioukhin, V.5
  • 25
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung Y., and Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3 (2000) 979-985
    • (2000) Nat. Neurosci. , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 26
    • 2942742564 scopus 로고    scopus 로고
    • Novel lipid modifications of secreted protein signals
    • Mann R.K., and Beachy P.A. Novel lipid modifications of secreted protein signals. Annu. Rev. Biochem. 73 (2004) 891-923
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 891-923
    • Mann, R.K.1    Beachy, P.A.2
  • 27
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V., Davey R.A., Zuo Y., Cunningham J.M., and Tabin C.J. Biochemical evidence that patched is the Hedgehog receptor. Nature 384 (1996) 176-179
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 28
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon A.P., Ingham P.W., and Tabin C.J. Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53 (2003) 1-114
    • (2003) Curr. Top. Dev. Biol. , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 29
    • 4143142328 scopus 로고    scopus 로고
    • Dependence receptors: Between life and death
    • Mehlen P., and Thibert C. Dependence receptors: Between life and death. Cell. Mol. Life Sci. 61 (2004) 1854-1866
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 1854-1866
    • Mehlen, P.1    Thibert, C.2
  • 30
    • 0030793114 scopus 로고    scopus 로고
    • Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro
    • Miao N., Wang M., Ott J.A., D'Alessandro J.S., Woolf T.M., Bumcrot D.A., Mahanthappa N.K., and Pang K. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro. J. Neurosci. 17 (1997) 5891-5899
    • (1997) J. Neurosci. , vol.17 , pp. 5891-5899
    • Miao, N.1    Wang, M.2    Ott, J.A.3    D'Alessandro, J.S.4    Woolf, T.M.5    Bumcrot, D.A.6    Mahanthappa, N.K.7    Pang, K.8
  • 31
    • 0024254534 scopus 로고
    • Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
    • Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120 (1988) 1061-1072
    • (1988) Genetics , vol.120 , pp. 1061-1072
    • Mohler, J.1
  • 32
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C., and Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 287 (1980) 795-801
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 33
    • 0032990662 scopus 로고    scopus 로고
    • Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog
    • Oppenheim R.W., Homma S., Marti E., Prevette D., Wang S., Yaginuma H., and McMahon A.P. Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog. Mol. Cell. Neurosci. 13 (1999) 348-361
    • (1999) Mol. Cell. Neurosci. , vol.13 , pp. 348-361
    • Oppenheim, R.W.1    Homma, S.2    Marti, E.3    Prevette, D.4    Wang, S.5    Yaginuma, H.6    McMahon, A.P.7
  • 35
  • 36
    • 33747827890 scopus 로고    scopus 로고
    • Hedgehog signal transduction: Signal integration and cross talk in development and cancer
    • Riobo N.A., Lu K., and Emerson Jr. C.P. Hedgehog signal transduction: Signal integration and cross talk in development and cancer. Cell Cycle 5 (2006) 1612-1615
    • (2006) Cell Cycle , vol.5 , pp. 1612-1615
    • Riobo, N.A.1    Lu, K.2    Emerson Jr., C.P.3
  • 37
    • 34247857432 scopus 로고    scopus 로고
    • Pathways of signal transduction employed by vertebrate Hedgehogs
    • Riobo N.A., and Manning D.R. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem. J. 403 (2007) 369-379
    • (2007) Biochem. J. , vol.403 , pp. 369-379
    • Riobo, N.A.1    Manning, D.R.2
  • 40
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H., Hui C., Nakafuku M., and Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124 (1997) 1313-1322
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 42
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J., and Beachy P.A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411 (2001) 349-354
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 43
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • Taipale J., Cooper M.K., Maiti T., and Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature 418 (2002) 892-897
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 45
    • 0031806560 scopus 로고    scopus 로고
    • Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages
    • Teillet M., Watanabe Y., Jeffs P., Duprez D., Lapointe F., and Le Douarin N.M. Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages. Development 125 (1998) 2019-2030
    • (1998) Development , vol.125 , pp. 2019-2030
    • Teillet, M.1    Watanabe, Y.2    Jeffs, P.3    Duprez, D.4    Lapointe, F.5    Le Douarin, N.M.6
  • 46
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • Tenzen T., Allen B.L., Cole F., Kang J.S., Krauss R.S., and McMahon A.P. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell. 10 (2006) 647-656
    • (2006) Dev. Cell. , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3    Kang, J.S.4    Krauss, R.S.5    McMahon, A.P.6
  • 48
    • 31744436876 scopus 로고    scopus 로고
    • Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
    • Varjosalo M., Li S.P., and Taipale J. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell. 10 (2006) 177-186
    • (2006) Dev. Cell. , vol.10 , pp. 177-186
    • Varjosalo, M.1    Li, S.P.2    Taipale, J.3
  • 49
    • 33646120095 scopus 로고    scopus 로고
    • Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    • Zhang W., Kang J.S., Cole F., Yi M.J., and Krauss R.S. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell 10 (2006) 657-665
    • (2006) Dev. Cell , vol.10 , pp. 657-665
    • Zhang, W.1    Kang, J.S.2    Cole, F.3    Yi, M.J.4    Krauss, R.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.