Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence

Proceedings of the SICE Annual Conference

Volumn , Issue , 2007, Pages 1353-1358

  Witt, Johannes ^a   Husser, Sebastian ^a   Kulms, Dagmar ^a   Barisic, Sandra ^a   Sawodny, Oliver ^a   Sauter, Thomas ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Apoptosis; I B ; IL 1; Mathematical modeling; NF B; Signal transduction; UVB

Indexed keywords

CELL DEATH;

ANNUAL CONFERENCE; APOPTOSIS; CONTROL ENGINEERS; EXPERIMENTAL DATA; FIT PARAMETERS; FUNCTIONAL DEPENDENCIES; IL-1; INDUCED APOPTOSIS; LITERATURE DATA; MATHEMATICAL MODELING; PARAMETER IDENTIFICATIONS; PARAMETERIZED; SIGNAL TRANSDUCTION; UVB;

ELECTRIC LOAD MANAGEMENT;

EID: 50249115198     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/SICE.2007.4421193     Document Type: Conference Paper

References (25)

1. A. Lawen, "Apoptosis-an introduction", Bioessays, Vol. 25, No. 9, pp. 888-896, 2003.
2. A. Ashkenazi and V. M. Dixit, "Death receptors: signaling and modulation", Science No. 281, Vol. 5381, pp. 1305-1308, 1998.
3. D. Kulms, H. Düssmann, B. Pöppelmann, S. Ständer, A. Schwarz, and T. Schwarz, "Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1)", Cell Death and Differentiation, Vol. 9, No. 6, pp. 598-608, 2002.
4. D. Kulms, E. Zeise, B. Pöppelmann and T. Schwarz, "DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way", Oncogene, Vol. 21, No. 38, pp. 5844-5851, 2002.
5. H. Walczak, R. E. Miller, K. Ariail, B. Gliniak, T. S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, C. Smith, P. Smolak, R. G. Goodwin, C. T. Rauch, J. C. Schuh and D. H. Lynch, "Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo", Nature Medicine, Vol. 5, No. 2, pp. 157-163, 1999.
6. B. Pöppelmann, K. Klimmek, E. Strozyk, R. Voss, T. Schwarz and D. Kulms, "NFκB-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis", Journal of Biological Chemistry, Vol. 280, No. 16, pp. 15635-15643, 2005.
7. J.A. DiDonato, M. Hayakawa, D. M. Rothwarf, E. Zandi and M. Karin, "A cytokine-responsive IκB kinase that activates the transcription factor NF-κB.", Nature Vol. 388, No. 6642, pp. 548-554, 1997.
8. G. Kothny-Wilkes, D. Kulms, B. Pöppelmann, T. A. Luger, M. Kubin and T. Schwarz, "Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand", Journal of Biological Chemistry, Vol. 273, No. 44, pp. 29247-29253, 1998.
9. S. Maeda, L. Chang, Z. Li, J. Luo, H. Leffert and M. Karin, "IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα.", Immunity, Vol. 19, No. 5, pp. 725-737, 2003.
10. M. Karin, Y. Yamamoto and Q. M. Wang, "The IKK NF-κB system: a treasure trove for drug development", Nature Reviews Drug Discovery, Vol. 3, No. 1, pp. 17-26, 2004.
11. H. Conzelmann, J. Saez-Rodriguez, T. Sauter, E. Bullinger, F. Allgöwer and E. D. Gilles, "Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.", Systems Biology (Stevenage), Vol. 1 No. 1, pp. 159-169, 2004.
12. A. Hoffmann, A. Levchenko, M.L. Scott and D. Baltimore, "The IκB-NF-κB signaling module: temporal control and selective gene activation", Science, Vol. 298, No. 5596, pp. 1241-1245, 2000.
13. T. Lipniacki, P. Paszek, A. R. A. R. Brasier, B. Luxon and M. Kimmel, "Mathematical model of NF-κB regulatory module", Journal of Theoretical Biology, Vol. 228, No. 2, pp. 195-215, 2004.
14. S. L. Werner, D. Barken and A. Hoffmann, "Stimulus specificity of gene expression programs determined by temporal control of IKK activity", Science, Vol. 309, No. 5742, pp. 1857-1861, 2005.
15. S. G. Park, T. Lee, H. Y. Kang, K. Park, K. Cho and G. Jung, "The influence of the signal dynamics of activated form of IKK on NF-κB and anti-apoptotic gene expressions: A systems biology approach", FEBS Letters Vol. 580, pp. 822-830, 2006.
16. S. Basak, H. Kim, J.D. Kearns, V. Tergaonkar, E. O'Dea, S. L. Werner, C. A. Benedict, C.F. Ware, G. Ghosh, I. M. Verma and A. Hoffmann "A fourth IκB protein within the NF-κB signaling module", Cell No. 128, Vol. 2, pp. 369-381, 2007.
17. T. Eissing, H. Conzelmann, E.D. Gilles, F. Allgöwer, E. Bullinger and P. Scheurich, "Bistability analyses of a caspase activation model for receptor-induced apoptosis", Journal of Biological Chemistry, Vol. 279 No. 35, pp. 36892-36897, 2004.
18. M. Fussenegger, J. E. Bailey, and J. Varner, "A mathematical model of caspase function in apoptosis", Nature Biotechnology, Vol. 18, No. 7, pp. 768-774, 2000.
19. K. Cho, S. Shin, H. Lee and O. Wolkenhauer, "Investigations Into the Analysis and Modeling of the TNFα-mediated NF-κB-Signaling Pathway", Genome Research Vol. 13, pp. 2413-2422, 2003.
20. M. Delhase, M. Hayakawa, Y. Chen and M. Karin, "Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation", Science Vol. 284, No. 5412, pp. 309-313, 1999
21. E. E. Qwarnstrom, R. C. Page, S. Gillis and S. K. Dower, "Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts", Journal of Biological Chemistry, Vol. 263, No. 17, pp. 8261-8269, 1988.
22. M. Grell, H. Wajant, G Zimmermann, and P. Scheurich, "The type 1 receptor (CD 120a) is the high-affinity receptor for soluble tumor necrosis factor", Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 2, pp. 570-575, 1998.
23. H. Hirai, T. Murakami, A. Urabe and F. Takaku, "Increased glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate", Cancer Research, Vol. 45, No. 6, pp. 2456-2461, 1985.
24. H. Kato, T. N. Faria, B. Stannard, R. Levy-Toledano, S.I. Taylor, C. T. Roberts, and D. LeRoith, "Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells", Journal of Cellular Physiology, Vol. 156, No. 1, pp. 145-152, 1993.
25. J. Nelder and R. Mead, "A simplex method for function minimization", The Computer Journal, Vol. 7, pp. 308-313, 1964.