Sulindac derivatives that activate the peroxisome proliferator-activated receptor γ but lack cyclooxygenase inhibition

Journal of Medicinal Chemistry

Volumn 51, Issue 16, 2008, Pages 4911-4919

  Felts, Andrew S ^a   Siegel, Brianna S ^b   Young, Shiu M ^b   Moth, Christopher W ^a   Lybrand, Terry P ^a   Dannenberg, Andrew J ^b   Marnett, Lawrence J ^a   Subbaramaiah, Kotha ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 BENZYLIDENE 5 FLUORO 1H INDEN 3 YL)ETHANOIC ACID; 2 (5 FLUORO 1H INDEN 3 YL)ETHANOIC ACID; 2 [1 (4 BROMOBENZYLIDENE) 5 FLUORO 1H INDEN 3YL]ETHANOIC ACID; 2 [1 (4 ETHYLNYLBENZYLIDENE) 5 FLUORO 1H INDEN 3 YL]ETHANOIC ACID; 2 [1 (4 TERT BUTOXYBENZYLIDENE) 5 FLUORO 1H INDEN 3 YL]ETHANOIC ACID; 2 [1 (BIPHENYL 4 YLMETHYLENE) 5 FLUORO 1H INDEN 3 YL]ETHANOIC ACID; 2 [1 [(2',4' DIFLUOROBIPHENYL 4 YL)METHYLENE] 5 FLUORO 1H INDEN 3 YL]ETHANOIC ACID; 2 [1 [4 (AZIDOMETHYL)BENZYLIDENE] 5 FLUORO 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (4 METHOXYBENZYLIDENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (4 METHYLBENZYLIDENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (NAPHTHALEN 1 YLMETHYLENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (NAPHTHALEN 2 YLMETHYLENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (QUINOLIN 8 YLMETHYLENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 (QUINOXALIN 2 YLMETHYLENE) 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [(4 FLUORONAPHTHALEN 1 YL)METHYLENE] 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [4 (METHYLSULFINYL)BENZYLIDENE] 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [4 (METHYLSULFONYL)BENZYLIDENE] 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [4 (TRIFLUOROMETHYL)BENZYLIDENE] 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [4 (TRIFLUOROMETHYLTHIO)BENZYLIDENE] 1H INDEN 3 YL]ETHANOIC ACID; 2 [5 FLUORO 1 [[4' (METHYLTHIO)BIPHENYL 4 YL]METHYLENE] 1H INDEN 3 YL]ETHANOIC ACID; [[3 (CARBOXYMETHYL) 5 FLUORO 1H INDEN 1 YLIDENE]METHYL]BENZOIC ACID; BENZYLIDENE DERIVATIVE; CARBOXYLIC ACID; FATTY ACID BINDING PROTEIN; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SULINDAC SULFIDE; TRITIUM; TROGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; SCINTILLATION;

BENZYLIDENE COMPOUNDS; CYCLOOXYGENASE INHIBITORS; PPAR GAMMA; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; SULINDAC;

EID: 50249111494     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm700969c     Document Type: Article

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