NMR-based urine analysis in rats: Prediction of proximal tubule kidney toxicity and phospholipidosis

Journal of Pharmacological and Toxicological Methods

Volumn 58, Issue 1, 2008, Pages 41-49

  Lienemann, Kai ^a   Plötz, Thomas ^a   Sabine, Pestel ^b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Biomarker; Ensemble; Kidney; Metabolomics; Metabonomics; Methods; Rat; Side effect; Support Vector Machine; Toxicity

Indexed keywords

2 BROMOETHYLAMINE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; AMIODARONE; AMPHOTERICIN B; CHLOROQUINE; CISPLATIN; FOLIC ACID; FUROSEMIDE; GENTAMICIN; HEXACHLOROBUTADIENE; HYDROCHLOROTHIAZIDE; HYDROQUINONE; HYDROXYETHYLCELLULOSE; IMIPRAMINE; INDOMETACIN; MERCURY CHLORIDE; NETILMICIN; POLOXAMER; SODIUM CHLORIDE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG SAFETY; EXPOSURE VARIABLE; FEMALE; KIDNEY PROXIMAL TUBULE; LIPIDOSIS; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PREDICTIVE VALIDITY; RAT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; URINALYSIS;

ANIMALS; DRUG ADMINISTRATION ROUTES; FEMALE; KIDNEY TUBULES, PROXIMAL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, ANIMAL; MULTIVARIATE ANALYSIS; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TOXICITY TESTS;

ANIMALIA; RATTUS;

EID: 50049123227     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.06.002     Document Type: Article

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