The beta-adrenergic blocker carvedilol restores L-type calcium current in a myocardial infarction model of rabbit

Chinese Medical Journal

Volumn 118, Issue 5, 2005, Pages 377-382

  Li, Xia ^a   Huang, Cong Xin ^a   Jiang, Hong ^a   Cao, Feng ^a   Wang, Teng ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Beta adrenergic blockers; Calcium channel; Myocardial infarction; Ventricular remodeling

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CARVEDILOL; ISOPRENALINE; MESSENGER RNA; PLACEBO;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CELL DENSITY; CELL STIMULATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG MECHANISM; GENE EXPRESSION; HEART INFARCTION; HEART MUSCLE CELL; MALE; NONHUMAN; PATCH CLAMP; PHARMACOLOGICAL PARAMETERS; RABBIT; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STEADY STATE; WESTERN BLOTTING; WHOLE CELL;

ACTION POTENTIALS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CARBAZOLES; MALE; MYOCARDIAL INFARCTION; PROPANOLAMINES; RABBITS; RANDOM ALLOCATION; VENTRICULAR REMODELING;

EID: 15044342968     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Young RL, Grundlach AL, Louis WJ. Altered cardiac hormone and contractile protein messenger RNA levels following left ventricular myocardial infarction in the rat: an in situ hybridization histochemical study. Cardiovasc Res 1998;37:187-201.
2. Bhatia A, Cooley R, Berger M, et al. The implantable cardioverter defibrillator: technology, indications, and impact on cardiovascular survival. Curr Probl Cardiol 2004;29:303-356.
3. Ellison KE, Hafley GE, Hickey K, et al. Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). Circulation 2002;106:2694-2699.
4. Kawai K, Qin F, Shite J, et al. Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. Am J Physiol Heart Circ Physiol 2004;287 :H1003-H1012.
5. Brehm BR, Bertsch D, von Fallois J, et al. Beta-blockers of the third generation inhibit endothelin-1 liberation, mRNA production and proliferation of human coronary smooth muscle and endothelial cells. J Cardiovasc Pharmacol 2000;36:S401-S403.
6. Maltsev VA, Sabbab HN, Undrovinas AI. Downregulation of sodium current in chronic heart failure: effect of long-term therapy with carvedilol. Cell Mol Life Sci 2002;59:1561-1568.
7. Lin GS, Lu JJ, Jiang XJ, et al. Autologous transplantation of bone marrow mononuclear cells improved heart function after myocardial infarction. Acta Pharmacol Sin 2004;25:876-886.
8. Hu D, Huang C, Jiang H, et al. Effects of BmkTXK beta on electrophysiological properties of rabbit atrial myocytes. Chin Med J 2003;116:1691-1696.
9. Hamill OP, Marty A, Neher E, et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391:85-100.
10. + current of chemoreceptor cells of the rabbit carotid body. J Physiol 2002;542:369-382.
11. Holt E, Tonnessen T, Lunde PK, et al. Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats. J Mol Cell Cardiol 1998; 30:1581-1593.
12. Kaab S, Nuss HB, Chiamvimonvat N, et al. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 1996;78:262-273.
13. Santos PEB, Barcellos LC, Mill JG, et al. Ventricular action potential and L-type calcium channel in infarct-induced hypertrophy in rats. J Cardiovasc Electrophysiol 1995;6:1004-1014.
14. Aimond F, Alvarez JL, Rauzier J-M, et al. Ionic basis of ventricular arrhythmias in remodeled rat heart during long-term myocardial infarction. Cardiovasc Res 1999; 42:402-415.
15. 2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart. Am J Physiol Heart Circ Physiol 2004; 287: H1046-1054.
16. Duff HJ, Offord J, West J, et al. Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle. Mol Pharmacol 1992;42:570-574.
17. 2+ current downregulation in rat atrial myocytes during heart failure. Circ Res 2001 ;89:607-613.
18. Prahash AJ, Gupta S, and Anand IS. Myocyte response to β-adrenergic stimulation is preserved in the noninfarcted myocardium of globally dysfunctional rat hearts after myocardial infarction. Circulation 2000; 102:1840-1846.
19. Kubo H, Margulies KB, Piacentino V, et al. Patients with end-stage congestive heart failure treated with β-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation 2001 ;104:1012-1018.