Use of a failing rabbit heart as a model to predict torsadogenicity

Toxicological Sciences

Volumn 93, Issue 1, 2006, Pages 205-212

  Kijtawornrat, Anusak ^a   Nishijima, Yoshinori ^a,b   Roche, Brian M ^b   Keene, Bruce W ^b,c   Hamlin, Robert L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b QTest Laboratories Inc   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Myocardial failure; Myocardial infarction; QT interval; Rabbits; Torsade de pointes; Vulnerability

Indexed keywords

AMIODARONE; CISAPRIDE; CLOFILIUM; DOFETILIDE; KETAMINE; QUINIDINE; VERAPAMIL; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG DOSE REGIMEN; DRUG EXPOSURE; ECHOCARDIOGRAPHY; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART RATE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PREDICTION; QT INTERVAL; QT PROLONGATION; RABBIT; RISK ASSESSMENT; SYSTOLE; TORSADE DES POINTES;

AMIODARONE; ANIMALS; CARDIAC OUTPUT, LOW; CISAPRIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; MODELS, ANIMAL; PHENETHYLAMINES; QUATERNARY AMMONIUM COMPOUNDS; QUINIDINE; RABBITS; SULFONAMIDES; TORSADES DE POINTES; VERAPAMIL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33747888565     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl025     Document Type: Article

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