Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4904-4906

  Hutt, Oliver E ^a   Reddy, Bollu S ^a   Nair, Sajiv K ^a   Reiff, Emily A ^a   Henri, John T ^a   Greiner, Jack F ^a   Chiu, Ting Lan ^b   VanderVelde, David G ^a   Amin, Elizabeth A ^b   Himes, Richard H ^a   Georg, Gunda I ^a,b  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

C 25 epothilone analogue; Cytotoxicity; Epothilones; Total synthesis; Tubulin assembly

Indexed keywords

BENZYLOXYEPOTHILONE C; EPOTHILONE DERIVATIVE; HYDROGEN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MACROLACTONIZATION; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; PROTEIN ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; EPOTHILONES; HUMANS; HYDROGEN BONDING; TUBULIN; TUBULIN MODULATORS;

EID: 49849105959     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.024     Document Type: Article

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