Characterization of Numb expression in astrocytomas

Neuropathology

Volumn 28, Issue 5, 2008, Pages 479-484

  Yan, Benedict ^b   Omar, Feroz Mohd ^c   Das, Kakoli ^b,c   Ng, Wai Hoe ^d   Lim, Chinghway ^e   Shiuan, Koh ^c   Yap, Celestial T ^c   Salto Tellez, Manuel ^a,b,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Astrocytoma; Cell division; Glioma; Malignancy; Numb

Indexed keywords

NUMB PROTEIN; PROTEIN;

ARTICLE; ASTROCYTOMA; CANCER CELL CULTURE; CARCINOGENESIS; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; NEURAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADULT; AGED; ASTROCYTOMA; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS;

EID: 49749111551     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2008.00907.x     Document Type: Article

References (28)

1. Lu B, Jan L, Jan YN. Control of cell divisions in the nervous system: symmetry and asymmetry. Annu Rev Neurosci 2000 23 : 531 556.
2. Uemura T, Shepherd S, Ackerman L, Jan LY, Jan YN. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 1989 58 : 349 360.
3. Shen Q, Zhong W, Jan YN, Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002 129 : 4843 4853.
4. Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 1996 17 : 43 53.
5. Petersen PH, Zou K, Krauss S, Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci 2004 7 : 803 811.
6. Zhong W, Jiang MM, Schonemann MD, Meneses JJ, Pedersen RA, Jan LY et al. Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci USA 2000 97 : 6844 6849.
7. Pece S, Serresi M, Santolini E et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004 167 : 215 221.
8. Colaluca IN, Tosoni D, Nuciforo P et al. NUMB controls p53 tumour suppressor activity. Nature 2008 451 : 76 80.
9. Di Marcotullio L, Ferretti E, Greco A et al. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 2006 8 : 1415 1423.
10. Caussinus E, Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 2005 37 : 1125 1129.
11. Kleihues P, Burger PC, Scheithauer BW. The new WHO classification of brain tumours. Brain Pathol 1993 3 : 255 268.
12. Santolini E, Puri C, Salcini AE et al. Numb is an endocytic protein. J Cell Biol 2000 151 : 1345 1352.
13. Nishimura T, Fukata Y, Kato K et al. CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol 2003 5 : 819 826.
14. Nishimura T, Yamaguchi T, Tokunaga A et al. Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell 2006 17 : 1273 1285.
15. Huang EJ, Li H, Tang AA et al. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev 2005 19 : 138 151.
16. Guo M, Jan LY, Jan YN. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 1996 17 : 27 41.
17. Spana EP, Doe CQ. Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 1996 17 : 21 26.
18. McGill MA, McGlade CJ. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 2003 278 : 23196 23203.
19. Phillips HS, Kharbanda S, Chen R et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006 9 : 157 173.
20. Somasundaram K, Reddy SP, Vinnakota K et al. Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene 2005 24 : 7073 7083.
21. Purow BW, Haque RM, Noel MW et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005 65 : 2353 2363.
22. Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J 2002 21 : 93 102.
23. Chen J, Xu J, Zhao W et al. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol 2005 37 : 2273 2283.
24. Verdi JM, Bashirullah A, Goldhawk DE et al. Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc Natl Acad Sci USA 1999 96 : 10472 10476.
25. Dho SE, French MB, Woods SA, McGlade CJ. Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem 1999 274 : 33097 33104.
26. Dho SE, Trejo J, Siderovski DP, McGlade CJ. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: structural determinants of numb association with the cortical membrane. Mol Biol Cell 2006 17 : 4142 4155.
27. Juven-Gershon T, Shifman O, Unger T, Elkeles A, Haupt Y, Oren M. The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol 1998 18 : 3974 3982.
28. Yogosawa S, Miyauchi Y, Honda R, Tanaka H, Yasuda H. Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun 2003 302 : 869 872.