Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: Does selectivity matter?

European Heart Journal

Volumn 29, Issue 16, 2008, Pages 1936-1948

  Opitz, Christian F ^a   Ewert, Ralf ^b   Kirch, Wilhelm ^c   Pittrow, David ^c  

^a German Red Cross Hospital   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Ambrisentan; Bosentan; Endothelin; ET A ETB; ET 1; ETRA; Pulmonary arterial hypertension; Receptor selectivity; Sitaxentan

Indexed keywords

ALANINE AMINOTRANSFERASE; AMBRISENTAN; ASPARTATE AMINOTRANSFERASE; BOSENTAN; CYCLOSPORIN A; ENDOTHELIN RECEPTOR ANTAGONIST; GLIBENCLAMIDE; HEMOGLOBIN; SILDENAFIL; SITAXSENTAN; WARFARIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HEADACHE; HEMOGLOBIN BLOOD LEVEL; HUMAN; PERIPHERAL EDEMA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QUALITY OF LIFE; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; STEADY STATE; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; WALKING;

ANTIHYPERTENSIVE AGENTS; ENDOTHELIN-1; FEMALE; HUMANS; HYPERTENSION, PULMONARY; ISOXAZOLES; MALE; PHENYLPROPIONATES; PULMONARY ARTERY; PYRIDAZINES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTORS, ENDOTHELIN; SULFONAMIDES; THIOPHENES; TREATMENT OUTCOME; VASCULAR RESISTANCE; WALKING;

EID: 49749102732     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn234     Document Type: Review

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