Unbalanced translocation, a major chromosome alteration causing loss of heterozygosity in human lung cancer

Oncogene

Volumn 27, Issue 35, 2008, Pages 4788-4797

  Ogiwara, H ^a   Kohno, T ^a   Nakanishi, H ^a   Nagayama, K ^a   Sato, M ^a   Yokota, J ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Loss of heterozygosity; Lung adenocarcinoma; Mitotic recombination; Tumor suppressor gene; Unbalanced translocation

Indexed keywords

ARTICLE; CANCER CELL; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; DNA STRAND BREAKAGE; GENE CONVERSION; GENOME ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; MICROARRAY ANALYSIS; MITOTIC RECOMBINATION; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPECTRAL KARYOTYPING; STRUCTURAL CHROMOSOME ABERRATION;

GENE CONVERSION; HUMANS; KARYOTYPING; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MITOSIS; RECOMBINATION, GENETIC; TRANSLOCATION, GENETIC;

EID: 49649122847     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.113     Document Type: Article

References (43)

1. Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D et al. (2001). Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci USA 98: 2538-2543.
2. Adams J, Williams SV, Aveyard JS, Knowles MA. (2005). Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss. Cancer Res 65: 66-75.
3. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K et al. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870.
4. Bosco G, Haber JE. (1998). Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics 150: 1037-1047.
5. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL et al. (1983). Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305: 779-784.
6. Colvy T, Noguch IM, Henschk EC, Vazquez M, Geisinger K, Yokose T et al. (2004). Adenocarcinoma. In: Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (eds). World Health Organization Classification of Tumors: Pathology and Genetics, Tumours of Lung, Pleura, Thymus and Heart. IARC Press: Lyon (France). pp 31-34.
7. Florl AR, Schulz WA. (2003). Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells. Genes Chromosomes Cancer 37: 141-148.
8. Gaasenbeek M, Howarth K, Rowan AJ, Gorman PA, Jones A, Chaplin T et al. (2006). Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers. Cancer Res 66: 3471-3479.
9. Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, Minna JD. (2000). Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 60: 4894-4906.
10. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T et al. (2005). Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913.
11. Grigorova M, Lyman RC, Caldas C, Edwards PA. (2005). Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet 162: 1-9.
12. James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee WK. (1989). Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci USA 86: 2858-2862.
13. Katsura Y, Sasaki S, Sato M, Yamaoka K, Suzukawa K, Nagasawa T et al. (2007). Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo. DNA Repair (Amst) 6: 639-648.
14. Kohno T, Yokota J. (2006). Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: deduction from structural analysis of breakpoints for deletions. DNA Repair (Amst) 5: 1273-1281.
15. Lasko D, Cavenee W, Nordenskjold M. (1991). Loss of constitutional heterozygosity in human cancer. Annu Rev Genet 25: 281-314.
16. Lieber MR, Ma Y, Pannicke U, Schwarz K. (2003). Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 4: 712-720.
17. Masuda A, Takahashi T. (2002). Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis. Oncogene 21: 6884-6897.
18. Mitelman F. (2000). Recurrent chromosome aberrations in cancer. Mutat Res 462: 247-253.
19. Mori N, Yokota J, Oshimura M, Cavenee WK, Mizoguchi H, Noguchi M et al. (1989). Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res 49: 5130-5135.
20. Naylor SL, Johnson BE, Minna JD, Sakaguchi AY. (1987). Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature 329: 451-454.
21. Pennaneach V, Putnam CD, Kolodner RD. (2006). Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae. Mol Microbiol 59: 1357-1368.
22. Phelps RM, Johnson BE, Ihde DC, Gazdar AF, Carbone DP, McClintock PR et al. (1996). NCI-Navy Medical Oncology Branch cell line data base. J Cell Biochem Suppl 24: 32-91.
23. Robles AI, Linke SP, Harris CC. (2002). The p53 network in lung carcinogenesis. Oncogene 21: 6898-6907.
24. Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S et al. (2003). Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63: 8634-8647.
25. Sakamoto H, Mori M, Taira M, Yoshida T, Matsukawa S, Shimizu K et al. (1986). Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci USA 83: 3997-4001.
26. Sasaki S, Kitagawa Y, Sekido Y, Minna JD, Kuwano H, Yokota J et al. (2003). Molecular processes of chromosome 9p21 deletions in human cancers. Oncogene 22: 3792-3798.
27. Sato M, Shames DS, Gazdar AF, Minna JD. (2007). A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol 2: 327-343.
28. Sato M, Takahashi K, Nagayama K, Arai Y, Ito N, Okada M et al. (2005). Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer 44: 405-414.
29. Schmidt L, Li F, Brown RS, Berg S, Chen F, Wei MH et al. (1995). Mechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation. Cancer J Sci Am 1: 191-195.
30. Schrock E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA et al. (1996). Multicolor spectral karyotyping of human chromosomes. Science 273: 494-497.
31. Sekido Y, Fong KM, Minna JD. (2003). Molecular genetics of lung cancer. Annu Rev Med 54: 73-87.
32. Sengupta S, Harris CC. (2005). p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 6: 44-55.
33. Shiseki M, Kohno T, Adachi J, Okazaki T, Otsuka T, Mizoguchi H et al. (1996). Comparative allelotype of early and advanced stage nonsmall cell lung carcinomas. Genes Chromosomes Cancer 17: 71-77.
34. Takahashi T, Haruki N, Nomoto S, Masuda A, Saji S, Osada H et al. (1999). Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene 18: 4295-4300.
35. Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B et al. (2001). Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci USA 98: 2698-2702.
36. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM et al. (2002). c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9: 1031-1044.
37. Virmani AK, Fong KM, Kodagoda D, McIntire D, Hung J, Tonk V et al. (1998). Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chromosomes Cancer 21: 308-319.
38. Weinberg R. (2007) Tumor suppressor gene. In: Weinberg R (ed). The Biology of Cancer. Garland Science, Taylor and Francis Group, LLC: New York. pp 209-254.
39. Yokota J, Kohno T. (2004). Molecular footprints of human lung cancer progression. Cancer Sci 95: 197-204.
40. Yokota J, Wada M, Shimosato Y, Terada M, Sugimura T. (1987). Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci USA 84: 9252-9256.
41. Zhao X, Li C, Paez JG, Chin K, Janne PA, Chen TH et al. (2004). An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res 64: 3060-3071.
42. Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J et al. (2002). Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109: 811-821.
43. Zhu X, Dunn JM, Goddard AD, Squire JA, Becker A, Phillips RA et al. (1992). Mechanisms of loss of heterozygosity in retinoblastoma. Cytogenet Cell Genet 59: 248-252.