Synthesis and biological evaluation of novel 4-substituted 1-{[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]methylidene} thiosemicarbazides as new class of potential antiprotozoal agents

Chemistry and Biodiversity

Volumn 5, Issue 5, 2008, Pages 764-776

  Bhat, Abdul R ^a   Athar, Fareeda ^a   Van Zyl, Robyn L ^b   Chen, Chien Teng ^b   Azam, Amir ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO N' [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]QUINOLINE 1 CARBOTHIOHYDRAZIDE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)BENZALDEHYDE; 4 (2 CHLOROBENZYL) 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 (2 METHYLPHENYL) 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 (3 METHYLPHENYL) 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 (4 METHYLPHENYL) 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 BENZYL 4 PHENYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 CYCLOHEXYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 CYCLOHEXYL 4 METHYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 CYCLOOCTYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 CYCLOPENTYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 METHYL 4 PHENYL 1 [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]THIOSEMICARBAZIDE; 4 METHYL N' [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]PIPERIZINE 1 CARBOTHIOHYDRAZIDE; 4 PHENYL N' [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]PIPERAZINE 1 CARBOTHIOHYDRAZIDE; 5 [4 (1,3 DIOXOLAN 2 YL)PHENYL] 10,15,20 TRIPHENYLPORPHYRIN; ANTIPROTOZOAL AGENT; CHLOROQUINE; HEMATIN; METRONIDAZOLE; N' [[4 (10,15,20 TRIPHENYLPORPHYRIN 5 YL)PHENYL]METHYLIDENE]PYRROLIDINE 1 CARBOTHIOHYDRAZIDE; QUININE; THIOSEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG; PORPHYRIN; SEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZIDE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; KIDNEY EPITHELIUM; PROTEIN SYNTHESIS; AMOEBA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DRUG EFFECT; PLASMODIUM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMOEBA; ANIMALS; ANTIPROTOZOAL AGENTS; MOLECULAR STRUCTURE; PLASMODIUM; PORPHYRINS; SEMICARBAZIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49649112709     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200890073     Document Type: Article

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