Cyclooctadiene Ru(II) complexes of thiophene-2-carboxaldehyde-derived thiosemicarbazones: synthesis, characterization and antiamoebic activity

European Journal of Medicinal Chemistry

Volumn 41, Issue 5, 2006, Pages 592-598

  Singh, Shailendra ^a   Athar, Fareeda ^a   Maurya, Mannar R ^b   Azam, Amir ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Antiamoebic activity; Entamoeba histolytica.; Ru(II) Complexes; Thiophene 2 carboxaldehyde; Thiosemicarbazones

Indexed keywords

4 (2 ADAMANTYL) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 (2 ETHYLPIPERIDINE) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 (4 BENZYLPIPERIDINE) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 (4 METHYLBENZYL) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 (4 PHENYLPIPERAZINE) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 2 TOLUIDINE 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 3 TOLUIDINE 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 4 TOLUIDINE 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 CYCLOHEXYL 4 METHYL 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; 4 METHYLPIPERIDINE 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE; ALDEHYDE DERIVATIVE; DICHLORO (4 (2 ADAMANTYL) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE)CYCLOOCTADIENE RUTHENIUM DERIVATIVE; DICHLORO (4 (2 ETHYLPIPERIDINE) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE)CYCLOOCTADIENE RUTHENIUM DERIVATIVE; DICHLORO (4 (4 PHENYLPIPERIDINE) 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE)CYCLOOCTADIENE RUTHENIUM DERIVATIVE; DICHLORO (4 CYCLOHEXYL 4 METHYL 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE) CYCLOOCTADIENE RUTHENIUM DERIVATIVE; DICHLORO (4 METHYLPIPERIDINE 1 (THIOPHENE 2 YLMETHYLENE)THIOSEMICARBAZIDE) CYCLOOCTADIENE RUTHENIUM DERIVATIVE; METRONIDAZOLE; RUTHENIUM COMPLEX; RUTHENIUM DERIVATIVE; THIOPHENE 2 CARBOXALDEHYDE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; IC 50; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE;

ALDEHYDES; AMEBICIDES; ANIMALS; CYCLOOCTANES; ENTAMOEBA HISTOLYTICA; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; THIOPHENES; THIOSEMICARBAZONES;

EID: 33646787785     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.01.014     Document Type: Article

References (34)

1. Schuster H., and Chiodini P.L. Curr. Opin. Infect. Dis. 14 (2001) 587-591
2. Lichtenstein A., Kondo A.T., Visvesvara G.S., Fernandez A., Paiva E.F., Mauad T., Dolhnikoff M., and Martins M.A. Thorax 60 (2005) 350-352
3. Adagu I.S., Nolder D., Warhurst D.C., and Rossignol J.F. J. Antimicrob. Chemother. 49 (2002) 103-111
4. Voogd C.E., Vander S.J.J., and Jacobs J.J. Mutat. Res. 26 (1974) 483-490
5. Easmon J., Purstinger G., Heinisch G., Roth T., Fiebig H.H., Holzer W., Jager W., Jenney M., and Hofmann J. J. Med. Chem. 44 (2001) 2164-2171
6. Seebacher W., Brun R., and Weis R. Eur. J. Pharm. Sci. 21 (2004) 225-233
7. Kolocouris A., Dimas K., Pannecouque C., Witvrouw M., Foscolos G.B., Stamatiou G., Fytas G., Zoidis G., Kolocouris N., Andrei G., Snoeck R., and Clercq E.D. Bioorg. Med. Chem. Lett. 12 (2002) 723-727
8. Tarua M., Ribuot C., Pera M.H., Taillandier G., Fatome M., Laval J.D., Demenge P., and Leclerc G. Eur. J. Med. Chem. 31 (1996) 589-595
9. Dimmock J.R., Pandeya S.N., Quail J.W., Pugazhenthi U., Allen T.M., Kao G.Y., Balzarini J., and Declercq E. Eur. J. Med. Chem. 30 (1995) 303-314
10. Aguirre G., Boiani L., Cerecetto H., Fernández M., González M., Denicola A., Otero L., Gambino D., Rigol C., Olea-Azar C., and Faundez M. Bioorg. Med. Chem. 12 (2004) 4885-4893
11. Du X., Guo C., Hansell E., Doyle P.S., Caffrey C.R., Holler T.P., McKerrow J.H., and Cohen F.E. J. Med. Chem. 45 (2002) 2695-2707
12. Du X., Hansell E., Engel J.C., Caffrey C.R., Cohen F.E., and McKerrow J.H. Chem. Biol. 7 (2000) 733-742
13. Hall I.H., Wong O.T., and Chapman J.M. Anticancer Drugs 6 (1995) 147
14. Liu M.C., Lin T.S., and Sartorelli A.C. Prog. Med. Chem. 32 (1995) 1-35
15. Liu M.C., Lin T.S., Cory J.G., and Cory A.H. J. Med. Chem. 39 (1996) 2586-2593
16. Garcia-Tojal J., Garcia-Orad A., Serra J.L., Pizarro J.L., Lezama L., Arriortua M.I., and Rojo T. J. Inorg. Biochem. 75 (1999) 45-54
17. Garcia-Tojal J., Pizarro J.L., Garcia-Orad A., Perez-Sanz A.R., Ugalde M.M., Dýaz A.A., Serra J.L., Arriortua M.I., and Rojo T. J. Inorg. Biochem. 86 (2001) 627-633
18. Savornin B., Madadi N.E., Delmas F., Gasquit M., Timon-David P., and Vanelle P. P., J. Meldonado. J. Pharm. Pharmacol. 43 (1991) 58-59
19. Ocal N., and Kaban S. Ind. J. Chem. 37B (1999) 1051-1053
20. Kratz F., Hartmann M., Keppler B., and Messori R. J. Biol. Chem. 269 (1994) 2581
21. Farrel N. In: Lippard S.J. (Ed). In Chemistry and Biochemistry of Platinum, Gold and other Chemotherapeutic Agents (1983), ACS Symp 279-297 (209)
22. Sanchez-Delgado R.A., Lazardi K., Rincon L., Urbina J.A., Hurbert A.J., and Noels A.N. J. Med. Chem. 36 (1993) 2041-2043
23. Sanchez-Delgado R.A., Navarro M., Perez H., and Urbina J.A. J. Med. Chem. 39 (1996) 1095-1099
24. Shailendra N., Bharti M.T.G., Garza D.E., Cruz-Vega J.C., Garza K., Saleem F., Naqvi A., and Azam. Bioorg. Med. Chem. Lett. 11 (2001) 2675-2678
25. Shailendra N., Bharti F., Naqvi A., and Azam. Bioorg. Med. Chem. Lett. 13 (2003) 689-692
26. Wright C.W., O'Neill M.J., Phillipson J.D., and Warhurst D.C. Antimicrob. Agents Chemother. 32 (1988) 1725-1729
27. Diamond L.S., Harlow D.R., Cunnick C.C., and Trans C.C. R. Soc. Trop. Med. Hyg. 72 (1978) 431-432
28. Gillin F.D., Reiner D.S., and Suffness M. Antimicrob. Agents Chemother. 22 (1982) 342-345
29. Keene A.T., Harris A., Phillipson J.D., and Warhurst D.C. Planta Med. (1986) 278-284
30. O'Sullivan D.G., Sadler P.W., and Webley C. Chemotherapy 59 (1963) 17-26
31. Albers M.O., Ashworth T.V., Oosthuizen H.E., and Singleton E. Inorg. Synth. 26 (1989) 68
32. Tain Y., Duan C., Zhao C., You X., Mak T.C.W., and Zhang Z. Inorg. Chem. 36 (1997) 1247-1252
33. Cedeno J.R., and Krogstad D.J. J. Infect. Dis. 148 6 (1983) 1090-1095
34. Dobek A.S., Klayman D.L., Dickson J.R.E.T., Scvill J.P., and Tramont E.C. Antimicrob. Agents Chemother. 28 (1980) 27-36