Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways

Toxicology and Applied Pharmacology

Volumn 231, Issue 2, 2008, Pages 135-141

  Pysher, Michele D ^a   Chen, Qin M ^a   Vaillancourt, Richard R ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Arsenic; FAK; Focal adhesion; Src; Vascular smooth muscle cell

Indexed keywords

ARSENIC; FOCAL ADHESION KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; P21 ACTIVATED KINASE 1; SCAVENGER RECEPTOR C;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL LYSATE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; DENSITOMETRY; ENZYME ACTIVATION; ENZYME INDUCTION; FOCAL ADHESION; IMMUNOPRECIPITATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; ARSENIC; BLOTTING, WESTERN; CELLS, CULTURED; DENSITOMETRY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENVIRONMENTAL EXPOSURE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; IMMUNOPRECIPITATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; P21-ACTIVATED KINASES; RATS; SRC-FAMILY KINASES;

EID: 49549110251     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.04.002     Document Type: Article

References (54)

1. Abram C.L., and Courtneidge S.A. Src family tyrosine kinases and growth factor signaling. Exp. Cell Res. 254 (2000) 1-13
2. Aplin A.E., Howe A., Alahari S.K., and Juliani R.L. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50 (1998) 197-263
3. Beeser A., Jaffer Z.M., Hofmann C., and Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J. Biol. Chem. 280 (2005) 36609-36615
4. Berk B.C. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol. Rev. 81 (2001) 999-1030
5. Bjorge J.D., Jakymiw A., and Fujita D.J. Selected glimpses into the activation and function of Src kinase. Oncogene 19 (2000) 5620-5635
6. Boggon T.J., and Eck M.J. Structure and regulation of Src family kinases. Oncogene 23 (2004) 7918-7927
7. Bokoch G.M. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72 (2003) 743-781
8. Bromann P.A., Korkaya H., and Courtneidge S.A. The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 23 (2004) 7957-7968
9. Brown M.C., and Turner C.E. Paxillin: adapting to change. Physiol. Rev. 84 (2004) 1315-1339
10. Centeno J.A., Mullick F.G., Martinez L., Page N.P., Gibb H., Longfellow D., Thompson C., and Ladich E.R. Pathology related to chronic arsenic exposure. Environ. Health Perspect. 110 (2002) 883-886
11. Chen H.C., and Feener E.P. MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation. Blood 103 (2004) 2636-2644
12. Chen R.Y., Kim O., Yang J.B., Sato K., Eisenmann K.M., McCarthy J., Chen H.G., and Qiu Y. Regulation of Akt/PKB activation by tyrosine phosphorylation. J. Biol. Chem. 276 (2001) 31858-31862
13. Clempus R.E., and Griendling K.K. Reactive oxygen species signaling in vascular smooth muscle cells. Cardiovasc. Res. 71 (2006) 216-225
14. Conus N.M., Hannan K.M., Cristiano B.E., Hemmings B.A., and Pearson R.B. Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. J. Biol. Chem. 277 (2002) 38021-38028
15. Cox B.D., Natarajan M., Stettner M.R., and Gladson C.L. New concepts regarding focal promotion of cell migration adhesion kinase and proliferation. J. Cell. Biochem. 99 (2006) 36-52
16. Eblen S.T., Slack J.K., Weber M.J., and Catling A.D. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes. Mol. Cell. Biol. 22 (2002) 6023-6033
17. Gerthoffer W.T. Mechanisms of vascular smooth muscle cell migration. Circ. Res. 100 (2007) 607-621
18. Goering P.L., Aposhian H.V., Mass M.J., Cebrian M., Beck B.D., and Waalkes M.P. The enigma of arsenic carcinogenesis: role of metabolism. Toxicol. Sci. 49 (1999) 5-14
19. Gregg D., Rauscher F.M., and Goldschmidt-Clermont P.J. Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch. Am. J. Physiol.-Cell Physiol. 285 (2003) C723-C734
20. Grillo S., Gremeaux T., Casamayor A., Alessi D.R., Le Marchand-Brustel Y., and Tanti J.F. Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 - potential involvement of Src kinase. Eur. J. Biochem. 267 (2000) 6642-6649
21. Howe A., Aplin A.E., Alahari S.K., and Juliano R.L. Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10 (1998) 220-231
22. Huang C., Jacobson K., and Schaller M.D. MAP kinases and cell migration. J. Cell Sci. 117 (2004) 4619-4628
23. Hunyady L., and Catt K.J. Pleiotropic AT(1) receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol. Endocrinol. 20 (2006) 953-970
24. Intengan H.D., and Schiffrin E.L. Vascular remodeling in hypertension - roles of apoptosis, inflammation, and fibrosis. Hypertension 38 (2001) 581-587
25. Ishizawar R., and Parsons S.J. c-Src and cooperating partners in human cancer. Cancer Cell 6 (2004) 209-214
26. Jiang T.Y., and Qiu Y. Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. J. Biol. Chem. 278 (2003) 15789-15793
27. King C.C., Gardiner E.M.M., Zenke F.T., Bohl B.P., Newton A.C., Hemmings B.A., and Bokoch G.M. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J. Biol. Chem. 275 (2000) 41201-41209
28. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 (2001) 249-261
29. Kumar R., and Vadlamudi R.K. Emerging functions of p21-activated kinases in human cancer cells. J. Cell. Physiol. 193 (2002) 133-144
30. Luttrell D.K., and Luttrell L.M. Not so strange bedfellows: G-protein-coupled receptors and Src family kinases. Oncogene 23 (2004) 7969-7978
31. Mitra S.K., and Schlaepfer D.D. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18 (2006) 516-523
32. Nelson P.R., Yamamura S., Mureebe L., Itoh H., and Kent K.C. Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase. J. Vasc. Surg. 27 (1998) 117-125
33. Park J., Hill M.M., Hess D., Brazil D.P., Hofsteenge J., and Hemmings B.A. Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J. Biol. Chem. 276 (2001) 37459-37471
34. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116 (2003) 1409-1416
35. Parsons J.T., Martin K.H., Slack J.K., Taylor J.M., and Weed S.A. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19 (2000) 5606-5613
36. Pysher M.D., Sollome J.J., Regan S., Cardinal T.R., Hoying J.B., Brooks H.L., and Vaillancourt R.R. Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic. Toxicol. Appl. Pharmacol. 224 (2007) 39
37. Romer L.H., Birukov K.G., and Garcia J.G.N. Focal adhesions - paradigm for a signaling nexus. Circ.Res. 98 (2006) 606-616
38. Rossman T.G., Uddin A.N., and Burns F.J. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol. Appl. Pharmacol. 198 (2004) 394-404
39. Schlaepfer D.D., Mitra S.K., and Ilic D. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim. Biophys. Acta-Mol. Cell Res. 1692 (2004) 77-102
40. Schoen A., Beck B., Sharma R., and Dube E. Arsenic toxicity at low doses: epidemiological and mode of action considerations. Toxicol. Appl. Pharmacol. 198 (2004) 253-267
41. Shupnik M.A. Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation. Oncogene 23 (2004) 7979-7989
42. Siesser P.M.F., and Hanks S.K. The signaling and biological implications of FAK overexpression in cancer. Clin. Cancer Res. 12 (2006) 3233-3237
43. Simeonova P.P., and Luster M.I. Arsenic carcinogenicity: relevance of c-Src activation. Mol. Cell. Biochem. 234 (2002) 277-282
44. Simeonova P.P., and Luster M.I. Arsenic and atherosclerosis. Toxicol. Appl. Pharmacol. 198 (2004) 444-449
45. Simeonova P.P., Wang S.Y., Hulderman T., and Luster M.I. c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic - role in carcinogenesis. J. Biol. Chem. 277 (2002) 2945-2950
46. Taniyama Y., Weber D.S., Rocic P., Hilenski L., Akers M.L., Park J., Hemmings B.A., Alexander R.W., and Griendling K.K. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Mol. Cell. Biol. 23 (2003) 8019-8029
47. Tapio S., and Grosche B. Arsenic in the aetiology of cancer. Mutat. Res.-Rev. Mutat. Res. 612 (2006) 215-246
48. Touyz R.M., He G., Wu X.H., Park J.B., El Mabrouk M., and Schiffrin E.L. Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension 38 (2001) 56-64
49. Touyz R.M., and Schiffrin E.L. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 52 (2000) 639-672
50. Wang C.H., Hsiao C.K., Chen C.L., Hsu L.I., Chiou H.Y., Chen S.Y., Hsueh Y.M., Wu M.M., and Chen C.J. A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicol. Appl. Pharmacol. 222 (2007) 315-326
51. Webb D.J., Donais K., Whitmore L.A., Thomas S.M., Turner C.E., Parsons J.T., and Horwitz A.F. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6 (2004) 154-161
52. Weber D.S., Taniyama Y., Rocic P., Seshiah P.N., Dechert M.A., Gerthoffer W.T., and Griendling K.K. Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration. Circ.Res. 94 (2004) 1219-1226
53. Wozniak M.A., Modzelewska K., Kwong L., and Keely P.J. Focal adhesion regulation of cell behavior. Biochim. Biophys. Acta-Mol. Cell Res. 1692 (2004) 103-119
54. Yang C.Y. Does arsenic exposure increase the risk of development of peripheral vascular diseases in humans?. J. Toxicol. Env. Health Part A 69 (2006) 1797-1804