The simplified reference tissue model for SPECT/PET brain receptor studies: Interpretation of its parameters

NuklearMedizin

Volumn 47, Issue 4, 2008, Pages 167-174

  Buchert, Ralph ^a   Thiele, F ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b PHILIPS RESEARCH LABORATORIES   (Germany)

Author keywords

Compartment model; Positron emission tomography; Raclopride; Receptor imaging; Simplified reference tissue method; Tracer kinetic modeling

Indexed keywords

BRAIN RECEPTOR; RACLOPRIDE C 11; TRACER;

ARTICLE; COMPARTMENT MODEL; COMPUTER SIMULATION; KINETICS; MATHEMATICAL ANALYSIS; MATHEMATICAL PARAMETERS; POSITRON EMISSION TOMOGRAPHY; SIMPLIFIED REFERENCE TISSUE MODEL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ALGORITHMS; BRAIN; COMPUTER SIMULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MODELS, NEUROLOGICAL; MODELS, STATISTICAL; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE; RECEPTORS, GABA; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 49449113240     PISSN: 00295566     EISSN: None     Source Type: Journal    
DOI: 10.3413/nukmed-0153     Document Type: Article

References (28)

1. Buchert R, Varga J, Mester J. Limitations of bi-linear regression analysis for the determination of receptor occupancy with positron emission tomography. Nucl Med Commun 2004; 25: 451-459.
2. Buck A, Gucker PM, Schonbachler RD et al. Evaluation of serotonergic transporters using PET and C-11 (+)McN-5652: Assessment of methods. J Cereb Blood Flow Metab 2000; 20: 253-262.
3. Catafau AM, Danus M, Bullich S et al. Characterization of the SPECT 5-HT2A receptor ligand I-123-R91150 in healthy volunteers: Part 1 - Pseudoequilibrium interval and quantification methods. J Nucl Med 2006; 47: 919-928.
4. Costes N, Merlet I, Ostrowsky K et al. A F-18-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. J Nucl Med 2005; 46: 1980-1989.
5. Cunningham VJ, Hume SP, Price GR et al. Compartmental analysis of diprenorphine binding to opiate receptors in the rat in vivo and its comparison with equilibrium data in vitro. J Cereb Blood Flow Metab 1991; 11: 1-9.
6. Farde L, Ehrin E, Eriksson L et al. Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Proc Natl Acad Sci USA 1985; 82: 3863-3867.
7. Farde L, Eriksson L, Blomquist G et al. Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET - a comparison to the equilibrium analysis. J Cereb Blood Flow Metab 1989; 9: 696-708.
8. Frankle WG, Slifstein M, Gunn RN et al. Estimation of serotonin transporter parameters with C-11-DASB in healthy humans: Reproducibility and comparison of methods. J Nucl Med 2006; 47: 815-826.
9. 11C]-DASB binding to the human serotonin transporter: modeling strategies. J Cereb Blood Flow Metab 2001; 21: 1342-1353.
10. 11C]WAY-100635 PET studies. Nucl Med Biol 2000; 27: 477-482.
11. Gunn RN, Lammertsma AA, Hume SP et al. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 1997; 6: 279-287.
12. 11C]WAY-100635 for PET. Neuroimage 1998; 8: 426-440.
13. Herzog H. Principles and mechanisms of receptor studies. Nuklearmedizin 1990; 29: 81.
14. Honer M, Bruhlmeier M, Missimer J et al. Dynamic imaging of striatal D-2 receptors in mice using quad-HIDAC PET. J Nucl Med 2004; 45: 464-470.
15. 3H]RX 821002 in rat brain: evaluation as a radioligand for central alpha 2-adrenoceptors. Int J Rad Appl Instrum B 1992; 19: 841-849.
16. Hwang DR, Narendran R, Huang YY et al. Quantitative analysis of (-)-N-C-11-propyl-norapomorphine in vivo binding in nonhuman primates. J Nucl Med 2004; 45: 338-346.
17. Innis RB, Cunningham VJ, Delforge J et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 2007; 27: 1533-1539.
18. 11C]raclopride studies. J Cereb Blood Flow Metab 1996; 16: 42-52.
19. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4: 153-158.
20. Lammertsma AA, Hume SP. A simplified reference tissue model for PET receptor studies. J Nucl Med 1996; 37: 1013-1013.
21. Lopresti BJ, Klunk WE, Mathis CA et al. Simplified quantification of Pittsburgh compound B amyloid imaging PET studies: A comparative analysis. J Nucl Med 2005; 46: 1959-1972.
22. Lundberg J, Odano I, Olsson H et al. Quantification of C-11-MADAM binding to the serotonin transporter in the human brain. J Nucl Med 2005; 46: 1505-1515.
23. Muzic RF Jr, Christian BT. Evaluation of objective functions for estimation of kinetic parameters. Med Phys 2006; 33: 342-353.
24. Parsey RV, Kegeles LS, Hwang DR et al. In vivo quantification of brain serotonin transporters in humans using C-11 McN 5652. J Nucl Med 2000; 41: 1465-1477.
25. Siessmeier T, Zhou Y, Buchholz HG et al. Parametric mapping of binding in human brain of D-2 receptor ligands of different affinities. J Nucl Med 2005; 46: 964-972.
26. Slifstein M, Frankle WG, Laruelle M. Ligand Tracer Kinetics: Theory and Application. In: Otte A, Audenaert K, Peremans K et al. (eds). Nuclear Medicine in Psychiatry. Berlin Heidelberg: Springer 2004; 75-93.
27. 11C]WAY- 100635 binding parameters with reference tissue models: effect of violations of model assumptions. Nucl Med Biol 2000; 27: 487-492.
28. Suehiro M, Scheffel U, Dannals RF et al. A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. J Nucl Med 1993; 34: 120-127.