Parametric mapping of binding in human brain of D2 receptor ligands of different affinities

Journal of Nuclear Medicine

Volumn 46, Issue 6, 2005, Pages 964-972

  Siessmeier, Thomas ^a   Zhou, Yun ^b   Buchholz, Hans Georg ^a   Landvogt, Christian ^a   Vernaleken, Ingo ^a   Piel, Markus ^a   Schirrmacher, Ralf ^a   Rösch, Frank ^a   Schreckenberger, Mathias ^a   Wong, Dean F ^b   Cumming, Paul ^c   Gründer, Gerhard ^d   Bartenstein, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Binding potential; Desmethoxyfallypride; Fallypride; Parametric; Quantification; Raclopride

Indexed keywords

DESMETHOXYFALLYPRIDE F 18; DOPAMINE 2 RECEPTOR; FALLYPRIDE F 18; RACLOPRIDE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; CARBON; DESMETHOXYFALLYPRIDE; FLUORINE; LIGAND; N ((1 ALLYL 2 PYRROLIDINYL)METHYL) 5 (3 FLUOROPROPYL) 2,3 DIMETHOXYBENZAMIDE; N-((1-ALLYL-2-PYRROLIDINYL)METHYL)-5-(3-FLUOROPROPYL)-2,3-DIMETHOXYBENZAMIDE; PYRROLIDINE DERIVATIVE; RACLOPRIDE; SALICYLAMIDE DERIVATIVE;

ADULT; ARTICLE; BINDING AFFINITY; BOLUS INJECTION; BRAIN MAPPING; BRAIN REGION; COMPARTMENT MODEL; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BINDING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN EXPERIMENT; IMAGE PROCESSING; LIGAND BINDING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; BRAIN; COMPARATIVE STUDY; DRUG POTENTIATION; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING;

ADULT; BENZAMIDES; BRAIN; CARBON RADIOISOTOPES; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINES; RACLOPRIDE; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; SALICYLAMIDES;

EID: 23044435473     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Brooks DJ, Ibanez V, Playford ED, et al. Presynaptic and postsynaptic striatal dopaminergic function in neuroacanthocytosis: a positron emission tomographic study. Ann Neurol. 1991;30:166-171.
2. 11C]FLB 457 binding to estrastriatal D2-like dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacology. 1997;133:396-404.
3. 2-like dopamine receptors by amisulpride in brain of patients with schizophrenia. Int J Neuropsychopharmacol. 2004;7:421-430.
4. 2 receptors correlate with central processing of alcohol cues and craving. Am J Psychiatry. 2004;161:1783-1785.
5. Farde L, Ehrin E, Eriksson L, et al. Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Proc Natl Acad Sci USA. 1985;82:3863-3867.
6. 3H-raclopride: a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol. 1985;34:2251-2255.
7. 11C]NMSP binding in living pig brain. Synapse. 2004;53:222-233.
8. 18F- Desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors. Life Sci. 1996;59:669-678.
9. 18F- desmethoxyfallypride [published correction appears in J Nucl Med. 2003;44:145]. J Nucl Med. 2003;44:109-116.
10. 18F-fallypride in nonhuman primates using positron emission tomography. Synapse. 1997;27:1-13.
11. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153-158.
12. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage. 1997;6:279-287.
13. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990;10:740-747.
14. Zhou Y, Endres CJ, Brasic JR, Huang SC, Wong DF. Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model. Neuroimage. 2003;18:975-989.
15. 11C]raclopride studies. J Cereb Blood Flow Metab. 1996;16:42-52.
16. Koepp MJ, Gunn RN, Lawrence AD, et al. Evidence for striatal dopamine release during a video game. Nature. 1998;393:266-268.
17. Zubieta JK, Smith YR, Bueller JA, et al. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science. 2001;293:311-315.
18. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab. 1991;11:735-744.
19. Gillings NM, Bender D, Falborg L, Marthi K, Munk OL, Cumming P. Kinetics of the metabolism of four PET radioligands in living minipigs. Nucl Med Biol. 2001;28:97-104.
20. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986;27:235-238.
21. Cumming P, Yokoi F, Chen A, et al. Pharmacokinetics of radiotracers in human plasma during positron emission tomography. Synapse. 1999;34:124-134.
22. Burger C, Mikolajczyk K, Grodzki M, Rudnicki P, Szabatin M, Buck A. JAVA tools quantitative post-processing of brain PET data [abstract]. J Nucl Med. 1998;39(suppl):277P.
23. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996;16:834-840.
24. Zhou Y, Huang SC, Bergsneider M, Wong DF. Improved parametric image generation using spatial-temporal analysis of dynamic PET studies. Neuroimage. 2002;15:697-707.
25. 11C]flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab. 1995;15:152-165.
26. 11C]raclopride binding. J Cereb Blood Flow Metab. 1998;18:941-950.
27. 11C- labelled raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey. Int J Appl Radiat Isot. 1985;36:269-273.
28. 18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer. Nucl Med Biol. 1995;22:283-296.
29. 18F-fallypride. Nucl Med Biol. 1999;26:519-527.
30. 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Synapse. 2002;46:170-188.
31. 11C]raclopride in the human brain in response to methylphenidate. J Nucl Med. 1999;40:1285-1291.
32. 11C]-raclopride in vivo: a test-retest analysis. J Cereb Blood Flow Metab. 1999;19:210-217.
33. Schreckenberger M, Hägele S, Siessmeier T, et al. The dopamine D2-receptor ligand F-18 desmethoxyfallypride is an appropriate PET tracer for the differential diagnosis of parkinsonism. Eur J Nucl Med Mol Imaging. 2004;31:1128-1135.
34. Endres CJ, Carson RE. Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab. 1998;18:1196-1210.
35. 11C]raclopride: optimization and signal-to-noise considerations. J Nucl Med. 2000;41:522-530.
36. Olsson H, Farde L. Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy: a simulation study based on experimental data. Neuroimage. 2001;14:936-945.
37. 18F-N- methylspiroperidol. Psychiatry Res. 1996;67:11-16.
38. Inoue M, Suhara T, Sudo Y, et al. Age-related reduction of estrastriatal dopamine D2 receptor measured by PET. Life Sci. 2001;69:1079-1084.
39. Rota Kops E, Herzog H, Schmid A, Holte S, Feinendegen LE. Performance characteristics of an eight-ring whole body PET scanner. J Comput Assist Tomogr. 1990;14:437-445.
40. Wienhard K, Eriksson L, Grootoonk S, Casey M, Pietrzyk U, Heiss WD. Performance evaluation of the positron scanner ECAT EXACT. J Comput Assist Tomogr. 1992;16:804-813.